N‐Terminal Modification of Gly‐His‐Tagged Proteins with Azidogluconolactone

Site‐specific protein modifications are vital for biopharmaceutical drug development. Gluconoylation is a non‐enzymatic, post‐translational modification of N‐terminal HisTags. We report high‐yield, site‐selective in vitro α‐aminoacylation of peptides, glycoproteins, antibodies, and virus‐like partic...

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Bibliographic Details
Published in:	Chembiochem : a European journal of chemical biology Vol. 22; no. 22; pp. 3199 - 3207
Main Authors:	Brune, Karl D., Liekniņa, Ilva, Sutov, Grigorij, Morris, Alexander R., Jovicevic, Dejana, Kalniņš, Gints, Kazāks, Andris, Kluga, Rihards, Kastaljana, Sabine, Zajakina, Anna, Jansons, Juris, Skrastiņa, Dace, Spunde, Karīna, Cohen, Alexander A., Bjorkman, Pamela J., Morris, Howard R., Suna, Edgars, Tārs, Kaspars
Format:	Journal Article
Language:	English
Published:	Weinheim Wiley Subscription Services, Inc 16.11.2021
Subjects:	Aminoacylation Antibodies Antigens Biopharmaceuticals click chemistry COVID-19 COVID-19 vaccines Drug development Esters Glycoproteins Glycosylation immunology nanoparticles Peptides protein modifications Proteins R&D Research & development Seroconversion Severe acute respiratory syndrome coronavirus 2 site-specific conjugation Viruses Yeast
ISSN:	1439-4227, 1439-7633, 1439-7633
Online Access:	Get full text
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