Voriconazole metabolism is influenced by severe inflammation: a prospective study

During an infection or inflammation, several drug-metabolizing enzymes in the liver are down-regulated, including cytochrome P450 iso-enzymes. Since voriconazole is extensively metabolized by cytochrome P450 iso-enzymes, the metabolism of voriconazole can be influenced during inflammation via reduce...

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Vydané v:	Journal of antimicrobial chemotherapy Ročník 72; číslo 1; s. 261
Hlavní autori:	Veringa, Anette, Ter Avest, Mendy, Span, Lambert F R, van den Heuvel, Edwin R, Touw, Daan J, Zijlstra, Jan G, Kosterink, Jos G W, van der Werf, Tjip S, Alffenaar, Jan-Willem C
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 01.01.2017
Predmet:	Academic Medical Centers Adult Aged Antifungal Agents - metabolism Antifungal Agents - pharmacokinetics Biotransformation Blood Chemical Analysis C-Reactive Protein - analysis Female Humans Inflammation - pathology Male Middle Aged Netherlands Prospective Studies Voriconazole - metabolism Voriconazole - pharmacokinetics
ISSN:	1460-2091, 1460-2091
On-line prístup:	Zistit podrobnosti o prístupe
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