Voriconazole metabolism is influenced by severe inflammation: a prospective study

During an infection or inflammation, several drug-metabolizing enzymes in the liver are down-regulated, including cytochrome P450 iso-enzymes. Since voriconazole is extensively metabolized by cytochrome P450 iso-enzymes, the metabolism of voriconazole can be influenced during inflammation via reduce...

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Bibliographic Details
Published in:	Journal of antimicrobial chemotherapy Vol. 72; no. 1; p. 261
Main Authors:	Veringa, Anette, Ter Avest, Mendy, Span, Lambert F R, van den Heuvel, Edwin R, Touw, Daan J, Zijlstra, Jan G, Kosterink, Jos G W, van der Werf, Tjip S, Alffenaar, Jan-Willem C
Format:	Journal Article
Language:	English
Published:	England 01.01.2017
Subjects:	Academic Medical Centers Adult Aged Antifungal Agents - metabolism Antifungal Agents - pharmacokinetics Biotransformation Blood Chemical Analysis C-Reactive Protein - analysis Female Humans Inflammation - pathology Male Middle Aged Netherlands Prospective Studies Voriconazole - metabolism Voriconazole - pharmacokinetics
ISSN:	1460-2091, 1460-2091
Online Access:	Get more information
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