A quality by design framework for developing nanocrystal bioenabling formulations

[Display omitted] The present study aims to outline a rational framework for the design and development of a 1.0% (w/v) hydrocortisone nanocrystal-based formulation, resorting to a simple, efficient, and scalable nanonization methodology, based on the high-pressure homogenization (HPH) technique. Ac...

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Bibliographic Details
Published in:	International journal of pharmaceutics Vol. 646; p. 123393
Main Authors:	Simões, Ana, Castro, Ricardo A.E., Veiga, Francisco, Vitorino, Carla
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 05.11.2023
Subjects:	Central composite design Crystallinity Nanocrystals Physical stability Quality by design Solid-state Topical dermatological product CPP Central composite design IPM ELS IVRT DS IVRR CQA BSC Topical dermatological product DSC CMA CMC TEWL UV tlag MW Crystallinity ER RSM Physical stability TGA QbD Solid-state ZP SEM Performance HLB HPH FMECA D ATR-FTIR PLC XRPD P SC RPN SHCB IVPT S NCHC Quality by design ANOVA CCCD HPLC MSE EHCB SSE CCD RMSE RP-HPLC Nanocrystals PEG NIR PG LD PVA DoE GRAS
ISSN:	0378-5173, 1873-3476, 1873-3476
Online Access:	Get full text
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