Autoregulation of cardiac output is overcome by adrenergic stimulation in the anaconda heart

Most vertebrates increase cardiac output during activity by elevating heart rate with relatively stable stroke volume. However, several studies have demonstrated 'intrinsic autoregulation' of cardiac output where artificially increased heart rate is associated with decreased stroke volume,...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Journal of experimental biology Ročník 220; číslo Pt 3; s. 336 - 340
Hlavní autoři: Joyce, William, Axelsson, Michael, Wang, Tobias
Médium: Journal Article
Jazyk:angličtina
Vydáno: England 01.02.2017
Témata:
Adrenergic alpha-Agonists - metabolism
Animals
Boidae - physiology
Cardiac Output
Heart - physiology
Homeostasis
Male
Myocardial Contraction
Norepinephrine - metabolism
Stroke Volume
Heart rate
Cardiovascular
Noradrenaline
Stroke volume
ISSN:1477-9145
On-line přístup:Zjistit podrobnosti o přístupu
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract Most vertebrates increase cardiac output during activity by elevating heart rate with relatively stable stroke volume. However, several studies have demonstrated 'intrinsic autoregulation' of cardiac output where artificially increased heart rate is associated with decreased stroke volume, leaving cardiac output unchanged. We explored the capacity of noradrenaline to overcome autoregulation in the anaconda heart. Electrically pacing in situ perfused hearts from the intrinsic heart rate to the maximum attainable resulted in a proportional decrease in stroke volume. However, noradrenaline, which increased heart rate to the same frequency as pacing, maintained stroke volume and thus increased cardiac output. In atrial and ventricular preparations, noradrenaline significantly increased the force of contraction and contraction kinetics. Thus, the increased contractility associated with adrenergic stimulation ameliorates filling limitations at high heart rates. Although heart rate appears the primary regulated variable during activity, this may only be achieved with compensatory amendments in myocardial contractility provided by adrenergic stimulation.
AbstractList Most vertebrates increase cardiac output during activity by elevating heart rate with relatively stable stroke volume. However, several studies have demonstrated 'intrinsic autoregulation' of cardiac output where artificially increased heart rate is associated with decreased stroke volume, leaving cardiac output unchanged. We explored the capacity of noradrenaline to overcome autoregulation in the anaconda heart. Electrically pacing in situ perfused hearts from the intrinsic heart rate to the maximum attainable resulted in a proportional decrease in stroke volume. However, noradrenaline, which increased heart rate to the same frequency as pacing, maintained stroke volume and thus increased cardiac output. In atrial and ventricular preparations, noradrenaline significantly increased the force of contraction and contraction kinetics. Thus, the increased contractility associated with adrenergic stimulation ameliorates filling limitations at high heart rates. Although heart rate appears the primary regulated variable during activity, this may only be achieved with compensatory amendments in myocardial contractility provided by adrenergic stimulation.
Author Wang, Tobias
Axelsson, Michael
Joyce, William
Author_xml – sequence: 1
  givenname: William
  orcidid: 0000-0002-3782-1641
  surname: Joyce
  fullname: Joyce, William
  email: william.joyce@bios.au.dk
  organization: Department of Zoophysiology, Aarhus University, Aarhus C 8000, Denmark william.joyce@bios.au.dk
– sequence: 2
  givenname: Michael
  surname: Axelsson
  fullname: Axelsson, Michael
  organization: Department of Biological and Environmental Sciences, University of Gothenburg, Gothenburg 405 30, Sweden
– sequence: 3
  givenname: Tobias
  surname: Wang
  fullname: Wang, Tobias
  organization: Department of Zoophysiology, Aarhus University, Aarhus C 8000, Denmark
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27875262$$D View this record in MEDLINE/PubMed
BookMark eNo1kDtPwzAUhS0Eog9Y-AHII0tKrpPGzlhVvKRKLLAhRTfOdesqsYvtIPXfUwl6lrN83xnOjF0674ixO8gXIErxuKd2AWUtCnnBplBKmdVQLidsFuM-P6ValtdsIqSSS1GJKftajckH2o49Jusd94ZrDJ1Fzf2YDmPiNnL_Q0H7gXh75NgFchS2VvOY7HD2rONpRxwdau865DvCkG7YlcE-0u1_z9nn89PH-jXbvL-8rVebTBeqThlJIWsANNiqqsPSCARtCKUChLYSre4KWQghQUFe56hIG6i01mRUWWgt5uzhb_cQ_PdIMTWDjZr6Hh35MTZwwmoBea5O6P0_OrYDdc0h2AHDsTk_In4B4zljsA
CitedBy_id crossref_primary_10_1016_j_cbpa_2019_03_023
crossref_primary_10_1242_jeb_199828
crossref_primary_10_1242_jeb_215335
crossref_primary_10_1007_s00360_018_1181_2
crossref_primary_10_1242_jeb_178194
crossref_primary_10_1007_s00360_017_1132_3
crossref_primary_10_1111_ede_12322
ContentType Journal Article
Copyright 2017. Published by The Company of Biologists Ltd.
Copyright_xml – notice: 2017. Published by The Company of Biologists Ltd.
DBID CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.1242/jeb.149237
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod no_fulltext_linktorsrc
Discipline Biology
EISSN 1477-9145
EndPage 340
ExternalDocumentID 27875262
Genre Journal Article
GroupedDBID ---
-DZ
-~X
0R~
18M
2WC
34G
39C
4.4
5GY
5RE
5VS
AAFWJ
ABDNZ
ABPPZ
ABRJW
ACGFS
ACIWK
ACNCT
ACPRK
ADBBV
ADVGF
AEILP
AENEX
AFRAH
AGGIJ
ALMA_UNASSIGNED_HOLDINGS
BAWUL
BTFSW
CGR
CJ0
CS3
CUY
CVF
DIK
DU5
E3Z
EBS
ECM
EIF
EJD
F5P
F9R
GX1
H13
HZ~
H~9
INIJC
KQ8
N9A
NPM
O9-
OK1
P2P
PQQKQ
RCB
RHI
RXW
S10
SJN
TAE
TN5
TR2
TWZ
UKR
UPT
W8F
WH7
WOQ
XSW
YQT
YR2
YVO
YZZ
ZCA
~02
7X8
ABUFD
ID FETCH-LOGICAL-c389t-e727911afab86da4f2a1cfea781a1b62bcd373227181090a8ecf16cccef843cc2
IEDL.DBID 7X8
ISICitedReferencesCount 11
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000394100300009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
IngestDate Sun Nov 09 13:53:31 EST 2025
Mon Jul 21 05:47:57 EDT 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue Pt 3
Keywords Heart rate
Cardiovascular
Noradrenaline
Stroke volume
Language English
License 2017. Published by The Company of Biologists Ltd.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c389t-e727911afab86da4f2a1cfea781a1b62bcd373227181090a8ecf16cccef843cc2
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-3782-1641
OpenAccessLink https://jeb.biologists.org/content/jexbio/220/3/336.full.pdf
PMID 27875262
PQID 1843921008
PQPubID 23479
PageCount 5
ParticipantIDs proquest_miscellaneous_1843921008
pubmed_primary_27875262
PublicationCentury 2000
PublicationDate 2017-02-01
PublicationDateYYYYMMDD 2017-02-01
PublicationDate_xml – month: 02
  year: 2017
  text: 2017-02-01
  day: 01
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Journal of experimental biology
PublicationTitleAlternate J Exp Biol
PublicationYear 2017
SSID ssj0000654
Score 2.2717173
Snippet Most vertebrates increase cardiac output during activity by elevating heart rate with relatively stable stroke volume. However, several studies have...
SourceID proquest
pubmed
SourceType Aggregation Database
Index Database
StartPage 336
SubjectTerms Adrenergic alpha-Agonists - metabolism
Animals
Boidae - physiology
Cardiac Output
Heart - physiology
Homeostasis
Male
Myocardial Contraction
Norepinephrine - metabolism
Stroke Volume
Title Autoregulation of cardiac output is overcome by adrenergic stimulation in the anaconda heart
URI https://www.ncbi.nlm.nih.gov/pubmed/27875262
https://www.proquest.com/docview/1843921008
Volume 220
WOSCitedRecordID wos000394100300009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings 1
isFullTextHit
isPrint
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1NS8NAEF3UKnjx-6N-sYLXpcmmySQnKWLxoKUHhR6EsDvZhQomtUmF_ntnkxS9CIKX3JYkm5k3b3cn7zF2AxFYDYAi0AGIPqAWCsJQJOChhkTF0tQ6s48wGsWTSTJuN9zKtq1yhYk1UGcFuj3ynvMlSaSTormdfQjnGuVOV1sLjXXWCYjKuMSESfwDicN-K0lKlaj3ZjQBAzEa-J1O1mVluPvfB9pjOy2h5IMmAvbZmskP2FZjMbk8ZK8DJ1LQGM7TJ-CF5VgHBfJiUc0WFZ-W3LVx0k0N10uu3K_dZk6AyCn731fjpjknqshVTghKq3jujLCrI_YyvH--exCto4JAIiaVMMRWCN2UVTqOMtW3UvlojYLYV76OpMYsAEpxKliuYVPFBq0fIaKx9LaI8pht5EVuThk3TkcGVGgQDC3xXAeV52NAAIKe8WTWZderaUspYt0xhMpNsSjT74nrspNm7tNZI62RSsKPUEby7A-jz9m2dDW2bqG-YB1L-Wou2SZ-VtNyflWHAl1H46cvUZbBqA
linkProvider ProQuest
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Autoregulation+of+cardiac+output+is+overcome+by+adrenergic+stimulation+in+the+anaconda+heart&rft.jtitle=Journal+of+experimental+biology&rft.au=Joyce%2C+William&rft.au=Axelsson%2C+Michael&rft.au=Wang%2C+Tobias&rft.date=2017-02-01&rft.eissn=1477-9145&rft.volume=220&rft.issue=Pt+3&rft.spage=336&rft_id=info:doi/10.1242%2Fjeb.149237&rft_id=info%3Apmid%2F27875262&rft_id=info%3Apmid%2F27875262&rft.externalDocID=27875262