MicroRNA-103 represses hepatic de novo lipogenesis and alleviates NAFLD via targeting FASN and SCD1

MicroRNAs are well acknowledged as key mediators in the development of chronic metabolic diseases, including NAFLD. However, their roles in hepatic lipid metabolism and fatty liver still remain well elucidated. Here, we found that miR-103 represses de novo lipogenesis (DNL) and dampens the developme...

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Veröffentlicht in:	Biochemical and biophysical research communications Jg. 524; H. 3; S. 716 - 722
Hauptverfasser:	Zhang, Meiyuan, Tang, Yan, Tang, E., Lu, Weirong
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 09.04.2020
Schlagworte:	de novo lipogenesis fatty liver hepatocytes homeostasis lipids lipogenesis liver mice microRNA miR-103 NAFLD Obesity pathogenesis miR-103 Obesity NAFLD de novo lipogenesis
ISSN:	0006-291X, 1090-2104, 1090-2104
Online-Zugang:	Volltext
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