The role of glutathione S-transferases (GSTs) in insecticide resistance in crop pests and disease vectors

•GSTs confer resistance by metabolizing or sequestering insecticides or by protecting against oxidative stress caused by insecticides.•The role of BdGSTe2, BdGSTe4 and AfGSTe2 in resistance has recently been validated by RNAi.•TuGSTd05, BmGSTu2 and AfGSTe2 have recently been shown to metabolize inse...

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Published in:Current opinion in insect science Vol. 27; pp. 97 - 102
Main Authors: Pavlidi, Nena, Vontas, John, Van Leeuwen, Thomas
Format: Journal Article
Language:English
Published: Netherlands Elsevier Inc 01.06.2018
Subjects:
Animals
arthropod pests
arthropods
Crops, Agricultural
disease vectors
genome
glutathione transferase
Glutathione Transferase - genetics
Glutathione Transferase - metabolism
Insect Proteins - genetics
Insect Proteins - metabolism
Insect Vectors - drug effects
Insect Vectors - genetics
Insecta - drug effects
Insecta - genetics
insecticide resistance
Insecticide Resistance - genetics
insecticides
Insecticides - pharmacology
insects
metabolism
oxidative stress
plant pests
resistance mechanisms
transcriptomics
ISSN:2214-5745, 2214-5753, 2214-5745, 2214-5753
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Summary:•GSTs confer resistance by metabolizing or sequestering insecticides or by protecting against oxidative stress caused by insecticides.•The role of BdGSTe2, BdGSTe4 and AfGSTe2 in resistance has recently been validated by RNAi.•TuGSTd05, BmGSTu2 and AfGSTe2 have recently been shown to metabolize insecticides in vitro. Insecticide resistance seriously threatens efficient arthropod pest management. Arthropod glutathione S-transferases (GSTs) confer resistance via direct metabolism or sequestration of chemicals, but also indirectly by providing protection against oxidative stress induced by insecticide exposure. To date, GST activity has been associated with resistance to all main classes of insecticides. However, recent advances in genome and transcriptome sequencing, together with modern genetic, functional and biochemical techniques, facilitate the unraveling of specific GST-mediated resistance mechanisms. Recently, the role of a number of GSTs (BdGSTe2, BdGSTe4, AfGSTe2) has been validated by (reverse) genetic methods in vivo, while a number of GSTs (BmGSTu2, TuGSTd05, AfGSTe2) have now been shown to metabolize insecticides in vitro.
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ISSN:2214-5745
2214-5753
2214-5745
2214-5753
DOI:10.1016/j.cois.2018.04.007