Gastrin promotes angiogenesis by activating HIF-1α/β-catenin/VEGF signaling in gastric cancer

Angiogenesis is recognized as a sign of cancer and facilitates cancer progression and metastasis. Suppression of angiogenesis is a desirable strategy for gastric cancer (GC) management. In this study, we showed a novel role of gastrin in angiogenesis of GC. We observed that treatment with gastrin 17...

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Bibliographic Details
Published in:	Gene Vol. 704; pp. 42 - 48
Main Authors:	Tang, E., Wang, Yongfeng, Liu, Tiemei, Yan, Bin
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.07.2019
Subjects:	Angiogenesis beta catenin cell proliferation Gastric cancer Gastrin gastrins hypoxia hypoxia-inducible factor 1 in vivo studies metastasis neoplasm progression normoxia stomach neoplasms vascular endothelial growth factors VEGF β-Catenin Angiogenesis COX-2 VEGF Gastrin β-Catenin GC G17 MTT Gastric cancer
ISSN:	0378-1119, 1879-0038, 1879-0038
Online Access:	Get full text
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