Of sex and determination: marking 25 years of Randy, the sex-reversed mouse

On Thursday 9 May 1991, the world awoke to front-page news of a breakthrough in biological research. From Washington to Wollongong, newspapers, radio and TV were abuzz with the story of a transgenic mouse in London called Randy. Why was this mouse so special? The mouse in question was a chromosomal...

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Bibliographic Details
Published in:Development (Cambridge) Vol. 143; no. 10; p. 1633
Main Authors: Koopman, Peter, Sinclair, Andrew, Lovell-Badge, Robin
Format: Journal Article
Language:English
Published: England 15.05.2016
Subjects:
Animals
Female
Male
Mice
Mice, Transgenic
Sex Determination Processes
Sex-Determining Region Y Protein - genetics
Testis
Transgenic mouse
Sry
Sex determination
ISSN:1477-9129, 1477-9129
Online Access:Get more information
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Summary:On Thursday 9 May 1991, the world awoke to front-page news of a breakthrough in biological research. From Washington to Wollongong, newspapers, radio and TV were abuzz with the story of a transgenic mouse in London called Randy. Why was this mouse so special? The mouse in question was a chromosomal female (XX) made male by the presence of a transgene containing the Y chromosome gene Sry This sex-reversal provided clear experimental proof that Sry was the elusive mammalian sex-determining gene. Twenty-five years on, we reflect on what this discovery meant for our understanding of how males and females arise and what remains to be understood.
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ISSN:1477-9129
1477-9129
DOI:10.1242/dev.137372