Silver Nanoparticles and Their Antibacterial Applications

Silver nanoparticles (AgNPs) have been imposed as an excellent antimicrobial agent being able to combat bacteria in vitro and in vivo causing infections. The antibacterial capacity of AgNPs covers Gram-negative and Gram-positive bacteria, including multidrug resistant strains. AgNPs exhibit multiple...

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Published in:	International journal of molecular sciences Vol. 22; no. 13; p. 7202
Main Authors:	Bruna, Tamara, Maldonado-Bravo, Francisca, Jara, Paul, Caro, Nelson
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 04.07.2021 MDPI
Subjects:	Antibiotics Antimicrobial agents Bacteria Biological activity Cytotoxicity Infections Microorganisms Multidrug resistant organisms Nanomaterials Nanoparticles Permeability Reagents Review Sulfur Toxicity
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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Abstract	Silver nanoparticles (AgNPs) have been imposed as an excellent antimicrobial agent being able to combat bacteria in vitro and in vivo causing infections. The antibacterial capacity of AgNPs covers Gram-negative and Gram-positive bacteria, including multidrug resistant strains. AgNPs exhibit multiple and simultaneous mechanisms of action and in combination with antibacterial agents as organic compounds or antibiotics it has shown synergistic effect against pathogens bacteria such as Escherichia coli and Staphylococcus aureus. The characteristics of silver nanoparticles make them suitable for their application in medical and healthcare products where they may treat infections or prevent them efficiently. With the urgent need for new efficient antibacterial agents, this review aims to establish factors affecting antibacterial and cytotoxic effects of silver nanoparticles, as well as to expose the advantages of using AgNPs as new antibacterial agents in combination with antibiotic, which will reduce the dosage needed and prevent secondary effects associated to both.
AbstractList	Silver nanoparticles (AgNPs) have been imposed as an excellent antimicrobial agent being able to combat bacteria in vitro and in vivo causing infections. The antibacterial capacity of AgNPs covers Gram-negative and Gram-positive bacteria, including multidrug resistant strains. AgNPs exhibit multiple and simultaneous mechanisms of action and in combination with antibacterial agents as organic compounds or antibiotics it has shown synergistic effect against pathogens bacteria such as Escherichia coli and Staphylococcus aureus. The characteristics of silver nanoparticles make them suitable for their application in medical and healthcare products where they may treat infections or prevent them efficiently. With the urgent need for new efficient antibacterial agents, this review aims to establish factors affecting antibacterial and cytotoxic effects of silver nanoparticles, as well as to expose the advantages of using AgNPs as new antibacterial agents in combination with antibiotic, which will reduce the dosage needed and prevent secondary effects associated to both.Silver nanoparticles (AgNPs) have been imposed as an excellent antimicrobial agent being able to combat bacteria in vitro and in vivo causing infections. The antibacterial capacity of AgNPs covers Gram-negative and Gram-positive bacteria, including multidrug resistant strains. AgNPs exhibit multiple and simultaneous mechanisms of action and in combination with antibacterial agents as organic compounds or antibiotics it has shown synergistic effect against pathogens bacteria such as Escherichia coli and Staphylococcus aureus. The characteristics of silver nanoparticles make them suitable for their application in medical and healthcare products where they may treat infections or prevent them efficiently. With the urgent need for new efficient antibacterial agents, this review aims to establish factors affecting antibacterial and cytotoxic effects of silver nanoparticles, as well as to expose the advantages of using AgNPs as new antibacterial agents in combination with antibiotic, which will reduce the dosage needed and prevent secondary effects associated to both. Silver nanoparticles (AgNPs) have been imposed as an excellent antimicrobial agent being able to combat bacteria in vitro and in vivo causing infections. The antibacterial capacity of AgNPs covers Gram-negative and Gram-positive bacteria, including multidrug resistant strains. AgNPs exhibit multiple and simultaneous mechanisms of action and in combination with antibacterial agents as organic compounds or antibiotics it has shown synergistic effect against pathogens bacteria such as Escherichia coli and Staphylococcus aureus. The characteristics of silver nanoparticles make them suitable for their application in medical and healthcare products where they may treat infections or prevent them efficiently. With the urgent need for new efficient antibacterial agents, this review aims to establish factors affecting antibacterial and cytotoxic effects of silver nanoparticles, as well as to expose the advantages of using AgNPs as new antibacterial agents in combination with antibiotic, which will reduce the dosage needed and prevent secondary effects associated to both.
Author	Caro, Nelson Maldonado-Bravo, Francisca Jara, Paul Bruna, Tamara
AuthorAffiliation	1 Centro de Investigación Austral Biotech, Facultad de Ciencias, Universidad Santo Tomás, Avenida Ejército 146, Santiago 8320000, Chile; francisca.maldonado@ug.uchile.cl 2 Departamento de Química, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Ñuñoa, Santiago 7800003, Chile; pjara@uchile.cl
AuthorAffiliation_xml	– name: 1 Centro de Investigación Austral Biotech, Facultad de Ciencias, Universidad Santo Tomás, Avenida Ejército 146, Santiago 8320000, Chile; francisca.maldonado@ug.uchile.cl – name: 2 Departamento de Química, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Ñuñoa, Santiago 7800003, Chile; pjara@uchile.cl
Author_xml	– sequence: 1 givenname: Tamara surname: Bruna fullname: Bruna, Tamara – sequence: 2 givenname: Francisca surname: Maldonado-Bravo fullname: Maldonado-Bravo, Francisca – sequence: 3 givenname: Paul surname: Jara fullname: Jara, Paul – sequence: 4 givenname: Nelson surname: Caro fullname: Caro, Nelson
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Snippet	Silver nanoparticles (AgNPs) have been imposed as an excellent antimicrobial agent being able to combat bacteria in vitro and in vivo causing infections. The...
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SourceType	Open Access Repository Aggregation Database Enrichment Source Index Database
StartPage	7202
SubjectTerms	Antibiotics Antimicrobial agents Bacteria Biological activity Cytotoxicity Infections Microorganisms Multidrug resistant organisms Nanomaterials Nanoparticles Permeability Reagents Review Sulfur Toxicity
Title	Silver Nanoparticles and Their Antibacterial Applications
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Volume	22
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