The Nucleotide-Free State of the Cannabinoid CB2/Gi Complex

In this issue of Cell, two papers report agonist-bound cryo-EM structures of the cannabinoid receptor, CB2, in complex with Gi. Importantly, beyond providing information that could help distinguish CB2 ligand binding from CB1, these structures support the existence of a nucleotide-free state during...

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Veröffentlicht in:Cell Jg. 180; H. 4; S. 603
Hauptverfasser: Lynch, Diane L, Hurst, Dow P, Reggio, Patricia H
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 20.02.2020
ISSN:1097-4172, 1097-4172
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Abstract In this issue of Cell, two papers report agonist-bound cryo-EM structures of the cannabinoid receptor, CB2, in complex with Gi. Importantly, beyond providing information that could help distinguish CB2 ligand binding from CB1, these structures support the existence of a nucleotide-free state during G-protein signaling.
AbstractList In this issue of Cell, two papers report agonist-bound cryo-EM structures of the cannabinoid receptor, CB2, in complex with Gi. Importantly, beyond providing information that could help distinguish CB2 ligand binding from CB1, these structures support the existence of a nucleotide-free state during G-protein signaling.
In this issue of Cell, two papers report agonist-bound cryo-EM structures of the cannabinoid receptor, CB2, in complex with Gi. Importantly, beyond providing information that could help distinguish CB2 ligand binding from CB1, these structures support the existence of a nucleotide-free state during G-protein signaling.In this issue of Cell, two papers report agonist-bound cryo-EM structures of the cannabinoid receptor, CB2, in complex with Gi. Importantly, beyond providing information that could help distinguish CB2 ligand binding from CB1, these structures support the existence of a nucleotide-free state during G-protein signaling.
Author Hurst, Dow P
Reggio, Patricia H
Lynch, Diane L
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  email: phreggio@uncg.edu
  organization: Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC 27412, USA. Electronic address: phreggio@uncg.edu
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Title The Nucleotide-Free State of the Cannabinoid CB2/Gi Complex
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