Changes associated with Ebola virus adaptation to novel species

Ebola viruses are not pathogenic but can be adapted to replicate and cause disease in rodents. Here, we used a structural bioinformatics approach to analyze the mutations associated with Ebola virus adaptation to rodents to elucidate the determinants of host-specific Ebola virus pathogenicity. We id...

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Bibliographic Details

Published in:	Bioinformatics (Oxford, England) Vol. 33; no. 13; pp. 1911 - 1915
Main Authors:	Pappalardo, Morena, Reddin, Ian G, Cantoni, Diego, Rossman, Jeremy S, Michaelis, Martin, Wass, Mark N
Format:	Journal Article
Language:	English
Published:	England 01.07.2017
Subjects:	Animals Cricetinae Ebolavirus - genetics Ebolavirus - metabolism Ebolavirus - pathogenicity Evolution, Molecular Guinea Pigs Humans Mice Mutation Protein Conformation Rodentia - virology Viral Proteins - genetics Viral Proteins - metabolism
ISSN:	1367-4803, 1367-4811, 1367-4811
Online Access:	Get full text
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