Changes associated with Ebola virus adaptation to novel species

Ebola viruses are not pathogenic but can be adapted to replicate and cause disease in rodents. Here, we used a structural bioinformatics approach to analyze the mutations associated with Ebola virus adaptation to rodents to elucidate the determinants of host-specific Ebola virus pathogenicity. We id...

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Veröffentlicht in:	Bioinformatics (Oxford, England) Jg. 33; H. 13; S. 1911 - 1915
Hauptverfasser:	Pappalardo, Morena, Reddin, Ian G, Cantoni, Diego, Rossman, Jeremy S, Michaelis, Martin, Wass, Mark N
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.07.2017
Schlagworte:	Animals Cricetinae Ebolavirus - genetics Ebolavirus - metabolism Ebolavirus - pathogenicity Evolution, Molecular Guinea Pigs Humans Mice Mutation Protein Conformation Rodentia - virology Viral Proteins - genetics Viral Proteins - metabolism
ISSN:	1367-4803, 1367-4811, 1367-4811
Online-Zugang:	Volltext
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