QTc interval prolongation during favipiravir therapy in an Ebolavirus-infected patient
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| Published in: | PLoS neglected tropical diseases Vol. 11; no. 12; p. e0006034 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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Public Library of Science
01.12.2017
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| ISSN: | 1935-2735, 1935-2727, 1935-2735 |
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| Author | Pittalis, Silvia Ippolito, Giuseppe Chinello, Pierangelo Nicastri, Emanuele Petrosillo, Nicola Biava, Gianluigi |
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| AuthorAffiliation | University of Geneva Hospitals, SWITZERLAND Lazzaro Spallanzani National Institute for Infectious Diseases (INMI), IRCCS, Rome, Italy |
| AuthorAffiliation_xml | – name: University of Geneva Hospitals, SWITZERLAND – name: Lazzaro Spallanzani National Institute for Infectious Diseases (INMI), IRCCS, Rome, Italy |
| Author_xml | – sequence: 1 givenname: Pierangelo orcidid: 0000-0002-7341-9000 surname: Chinello fullname: Chinello, Pierangelo – sequence: 2 givenname: Nicola surname: Petrosillo fullname: Petrosillo, Nicola – sequence: 3 givenname: Silvia surname: Pittalis fullname: Pittalis, Silvia – sequence: 4 givenname: Gianluigi surname: Biava fullname: Biava, Gianluigi – sequence: 5 givenname: Giuseppe surname: Ippolito fullname: Ippolito, Giuseppe – sequence: 6 givenname: Emanuele orcidid: 0000-0002-5606-8712 surname: Nicastri fullname: Nicastri, Emanuele |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29283993$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.5414/CP202388 10.1016/j.jcmg.2016.06.004 10.1002/path.4456 10.1016/S0140-6736(15)61095-9 10.1093/cid/ciw571 10.1016/j.ejphar.2003.11.003 10.1016/j.antiviral.2013.09.015 10.1086/508873 10.1016/S1473-3099(14)71047-3 10.1097/CCM.0000000000001197 10.1016/j.antiviral.2014.02.014 10.1128/AAC.46.4.977-981.2002 10.1592/phco.21.16.233S.33992 10.1053/j.ajkd.2009.11.019 10.1093/infdis/jiv357 10.1371/journal.pmed.1001967 10.1086/516614 |
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| Notes | ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 Membership of the INMI Ebola Team is provided in the Acknowledgments. Authors SP, GB, and GI contributed equally to preparing the case discussion and reviewed the manuscript. Authors PC, NP, and EN contributed equally to preparing the case report. The authors have declared that no competing interests exist. |
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| References_xml | – volume: 53 start-page: 866 year: 2015 ident: ref5 article-title: Lack of effect of favipiravir, a novel antiviral agent, on the QT interval in healthy Japanese adults publication-title: Int J Clin Pharmacol Ther doi: 10.5414/CP202388 – volume: 10 start-page: 711 year: 2017 ident: ref15 article-title: Cardiac MRI findings suggest myocarditis in severe Ebola virus disease publication-title: JACC Cardiovasc Imaging doi: 10.1016/j.jcmg.2016.06.004 – volume: 235 start-page: 153 year: 2015 ident: ref17 article-title: Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses publication-title: J Pathol doi: 10.1002/path.4456 – volume: 385 start-page: 2350 year: 2015 ident: ref9 article-title: Favipiravir–a prophylactic treatment for Ebola contacts? publication-title: Lancet doi: 10.1016/S0140-6736(15)61095-9 – volume: 63 start-page: 1288 year: 2016 ident: ref10 article-title: Clinical and virological characteristics of Ebola virus disease patients treated with favipiravir (T-705)–Sierra Leone, 2014 publication-title: Clin Infect Dis doi: 10.1093/cid/ciw571 – volume: 484 start-page: 41 year: 2004 ident: ref12 article-title: Inhibition of hERG K+ currents by antimalarial drugs in stably transfected HEK293 cells publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2003.11.003 – volume: 100 start-page: 446 year: 2013 ident: ref3 article-title: Favipiravir (T-705), a novel viral RNA polymerase inhibitor publication-title: Antiviral Res doi: 10.1016/j.antiviral.2013.09.015 – volume: 289 start-page: 2120 year: 2003 ident: ref6 article-title: What clinicians should know about the QT interval publication-title: JAMA – volume: 43 start-page: 1603 year: 2006 ident: ref1 article-title: Antimicrobial-associated QT interval prolongation: pointes of interest publication-title: Clin Infect Dis doi: 10.1086/508873 – volume: 15 start-page: 150 year: 2015 ident: ref18 article-title: Dose regimen of favipiravir for Ebola virus disease publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(14)71047-3 – volume: 43 start-page: 2066 year: 2015 ident: ref14 article-title: Critical care for multiple organ failure secondary to Ebola virus disease in the United States publication-title: Crit Care Med doi: 10.1097/CCM.0000000000001197 – volume: 105 start-page: 17 year: 2014 ident: ref8 article-title: Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model publication-title: Antiviral Res doi: 10.1016/j.antiviral.2014.02.014 – volume: 46 start-page: 977 year: 2002 ident: ref7 article-title: In vitro and in vivo activities of anti-influenza virus compound T-705 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.46.4.977-981.2002 – volume: 21 start-page: 233S year: 2001 ident: ref11 article-title: Pharmacokinetics and pharmacodynamics of fluoroquinolones publication-title: Pharmacotherapy doi: 10.1592/phco.21.16.233S.33992 – volume: 56 start-page: 112 year: 2010 ident: ref13 article-title: A case series of proton pump inhibitor-induced hypomagnesemia publication-title: Am J Kidney Dis doi: 10.1053/j.ajkd.2009.11.019 – volume: 213 start-page: 57 year: 2016 ident: ref16 article-title: Necrotizing scleritis, conjunctivitis, and other pathologic findings in the left eye and brain of an Ebola virus-infected Rhesus Macaque (Macaca mulatta) with apparent recovery and a delayed time of death publication-title: J Infect Dis doi: 10.1093/infdis/jiv357 – volume: 13 start-page: e1001967 year: 2016 ident: ref4 article-title: Experimental treatment with Favipiravir for Ebola virus disease (the JIKI Trial): a historically controlled, single-arm proof-of-concept trial in Guinea publication-title: PLoS Med doi: 10.1371/journal.pmed.1001967 – volume: 44 start-page: 1388 year: 2007 ident: ref2 article-title: QT interval prolongation and antiretroviral treatment: another point of interest publication-title: Clin Infect Dis doi: 10.1086/516614 – reference: 17443482 - Clin Infect Dis. 2007 May 15;44(10):1388-9; 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| Title | QTc interval prolongation during favipiravir therapy in an Ebolavirus-infected patient |
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