Quantitative proteomic profiling of extracellular matrix and site-specific collagen post-translational modifications in an in vitro model of lung fibrosis

Lung fibrosis is characterized by excessive deposition of extracellular matrix (ECM), in particular collagens, by fibroblasts in the interstitium. Transforming growth factor-β1 (TGF-β1) alters the expression of many extracellular matrix (ECM) components produced by fibroblasts, but such changes in E...

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Bibliographic Details
Published in:	Matrix biology plus Vol. 1; p. 100005
Main Authors:	Merl-Pham, Juliane, Basak, Trayambak, Knüppel, Larissa, Ramanujam, Deepak, Athanason, Mark, Behr, Jürgen, Engelhardt, Stefan, Eickelberg, Oliver, Hauck, Stefanie M., Vanacore, Roberto, Staab-Weijnitz, Claudia A.
Format:	Journal Article
Language:	English
Published:	Elsevier 01.02.2019
Subjects:	PTM, post-translational modification LH, lysyl hydroxylase DCN, decorin FN1, fibronectin 1 Collagen post-translational modifications ECM, extracellular matrix 3-HyP, 3-hydroxyproline TGF-β, transforming growth factor β P3H, prolyl-3-hydroxylase PCA, principal component analysis LOX(L), lysyl oxidase(-like) TGM2, transglutaminase 1 Lysyl glycosylation Prolyl hydroxylation Extracellular matrix PAI1, plasminogen activator inhibitor 1 G-HyK, galactosylhydroxylysine SEMA7A, semaphorin 7a AGC, automatic gain control HyP, hydroxyproline Lysyl hydroxylation 4-HyP, 4-hydroxyproline PLOD (LH), procollagen-lysine,2-oxoglutarate 5-dioxygenases (lysyl hydroxylases) GG-HyK, glucosylgalactosylhydroxylysine ILD, interstitial lung disease P4H, prolyl-4-hydroxylase α-SMA, α-smooth muscle actin ANXA11, annexin A11 HyK, hydroxylysine IPF, idiopathic pulmonary fibrosis Pulmonary fibrosis VCAN, versican Collagen Transforming growth factor-β BGN, biglycan COL1A1, collagen-I alpha 1 chain LTBP2, latent-transforming growth factor β -binding protein 2 Xaa, Xaa position in the Gly-Xaa-Yaa repeat in triple-helical collagen Yaa, Yaa position in the Gly-Xaa-Yaa repeat in triple-helical collagen
ISSN:	2590-0285, 2590-0285
Online Access:	Get full text
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