New T2 lesions enable an earlier diagnosis of multiple sclerosis in clinically isolated syndromes

In clinically isolated syndromes, the new McDonald criteria for multiple sclerosis diagnosis require new gadolinium‐enhancing lesions for dissemination in time at a 3‐month follow‐up magnetic resonance imaging scan. In a cohort of 56 patients, these criteria were specific (95%) but less sensitive (5...

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Vydáno v:Annals of neurology Ročník 53; číslo 5; s. 673 - 676
Hlavní autoři: Dalton, Catherine M., Brex, Peter A., Miszkiel, Katherine A., Fernando, Kryshani, MacManus, David G., Plant, Gordon T., Thompson, Alan J., Miller, David H.
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York Wiley Subscription Services, Inc., A Wiley Company 01.05.2003
Willey-Liss
Témata:
Adolescent
Adult
Biological and medical sciences
Female
Follow-Up Studies
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Multiple Sclerosis - pathology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Sensitivity and Specificity
Severity of Illness Index
Human
Nervous system diseases
Multiple sclerosis
Sensitivity
Specificity
Central nervous system disease
Medical imagery
Diagnosis
Technique
Nuclear magnetic resonance imaging
Inflammatory disease
ISSN:0364-5134, 1531-8249
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Popis
Shrnutí:In clinically isolated syndromes, the new McDonald criteria for multiple sclerosis diagnosis require new gadolinium‐enhancing lesions for dissemination in time at a 3‐month follow‐up magnetic resonance imaging scan. In a cohort of 56 patients, these criteria were specific (95%) but less sensitive (58%) for clinically definite multiple sclerosis at 3 years. If new T2 lesions were allowed as an alternative for dissemination in time, sensitivity increased (74%) with maintained specificity (92%), enabling an accurate diagnosis of multiple sclerosis in more patients. Ann Neurol 2003;53:673–676
Bibliografie:ArticleID:ANA10580
istex:C7F8FFF0E8627EA49D70752E609E0CFC9662707F
ark:/67375/WNG-VX75JWW7-0
Multiple Sclerosis Society of Great Britain and Northern Ireland
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.10580