Expression of cysteinyl leukotriene receptor 1 in human traumatic brain injury and brain tumors

Cysteinyl leukotrienes (CysLTs) are potent proinflammatory mediators. CysLT receptor 1 (CysLT 1) is one of the two CysLT receptors that has been cloned. Although the expression of CysLT 1 in the brain has been demonstrated by Northern blot and RT-PCR analyses, the location of CysLT 1 in the brain re...

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Bibliographic Details
Published in:Neuroscience letters Vol. 363; no. 3; pp. 247 - 251
Main Authors: Zhang, Wei-Ping, Hu, Hua, Zhang, Lei, Ding, Wei, Yao, Hong-Tian, Chen, Ke-Da, Sheng, Wen-Wen, Chen, Zhong, Wei, Er-Qing
Format: Journal Article
Language:English
Published: Shannon Elsevier Ireland Ltd 17.06.2004
Elsevier
Subjects:
Adult
Aged
Aged, 80 and over
Astrocytoma
Biological and medical sciences
Blotting, Northern - methods
Brain Injuries - metabolism
Brain Neoplasms - metabolism
Cysteinyl leukotriene receptor 1
Female
Fundamental and applied biological sciences. Psychology
Ganglioglioma
Gene Expression
Humans
Immunohistochemistry - methods
Injuries of the nervous system and the skull. Diseases due to physical agents
Male
Medical sciences
Membrane Proteins - genetics
Membrane Proteins - metabolism
Metastatic adenocarcinoma
Microvascular endothelium
Middle Aged
Receptors, Leukotriene - genetics
Receptors, Leukotriene - metabolism
Reverse Transcriptase Polymerase Chain Reaction - methods
Time Factors
Traumas. Diseases due to physical agents
Traumatic brain injury
Vertebrates: nervous system and sense organs
Ganglioglioma
Traumatic brain injury
Microvascular endothelium
Astrocytoma
Cysteinyl leukotriene receptor 1
Metastatic adenocarcinoma
Adenocarcinoma
Human
Nervous system diseases
Leukotriene receptor
Central nervous system
Malignant tumor
Trauma
Encephalon
Endothelium
Microcirculation
Glioma
Central nervous system disease
Lesion
ISSN:0304-3940, 1872-7972
Online Access:Get full text
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Summary:Cysteinyl leukotrienes (CysLTs) are potent proinflammatory mediators. CysLT receptor 1 (CysLT 1) is one of the two CysLT receptors that has been cloned. Although the expression of CysLT 1 in the brain has been demonstrated by Northern blot and RT-PCR analyses, the location of CysLT 1 in the brain remains unknown. The objective of this study was to examine the distribution of CysLT 1 by immunohistochemical analysis in human brains with traumatic injury or tumors. CysLT 1 was expressed intensely in the microvascular endothelial cells in both normal and abnormal conditions. At 8 days after traumatic injury, microvascular regeneration was found and all of the endothelial cells highly expressed CysLT 1. In gray and white matters of the normal regions of the brain, CysLT 1 was expressed weekly or not at all. However, the CysLT 1 expression increased in the neuron- and glial-appearing cells in gray and white matters after traumatic brain injury. CysLT 1 was also detected in astrocytoma, ganglioglioma and metastatic adenocarcinoma, and the expression in the neuron- and glial-appearing cells around brain tumors increased robustly.
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ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2004.03.088