Expression of cysteinyl leukotriene receptor 1 in human traumatic brain injury and brain tumors

Cysteinyl leukotrienes (CysLTs) are potent proinflammatory mediators. CysLT receptor 1 (CysLT 1) is one of the two CysLT receptors that has been cloned. Although the expression of CysLT 1 in the brain has been demonstrated by Northern blot and RT-PCR analyses, the location of CysLT 1 in the brain re...

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Vydáno v:	Neuroscience letters Ročník 363; číslo 3; s. 247 - 251
Hlavní autoři:	Zhang, Wei-Ping, Hu, Hua, Zhang, Lei, Ding, Wei, Yao, Hong-Tian, Chen, Ke-Da, Sheng, Wen-Wen, Chen, Zhong, Wei, Er-Qing
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Shannon Elsevier Ireland Ltd 17.06.2004 Elsevier
Témata:	Adult Aged Aged, 80 and over Astrocytoma Biological and medical sciences Blotting, Northern - methods Brain Injuries - metabolism Brain Neoplasms - metabolism Cysteinyl leukotriene receptor 1 Female Fundamental and applied biological sciences. Psychology Ganglioglioma Gene Expression Humans Immunohistochemistry - methods Injuries of the nervous system and the skull. Diseases due to physical agents Male Medical sciences Membrane Proteins - genetics Membrane Proteins - metabolism Metastatic adenocarcinoma Microvascular endothelium Middle Aged Receptors, Leukotriene - genetics Receptors, Leukotriene - metabolism Reverse Transcriptase Polymerase Chain Reaction - methods Time Factors Traumas. Diseases due to physical agents Traumatic brain injury Vertebrates: nervous system and sense organs Ganglioglioma Traumatic brain injury Microvascular endothelium Astrocytoma Cysteinyl leukotriene receptor 1 Metastatic adenocarcinoma Adenocarcinoma Human Nervous system diseases Leukotriene receptor Central nervous system Malignant tumor Trauma Encephalon Endothelium Microcirculation Glioma Central nervous system disease Lesion
ISSN:	0304-3940, 1872-7972
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Shrnutí:	Cysteinyl leukotrienes (CysLTs) are potent proinflammatory mediators. CysLT receptor 1 (CysLT 1) is one of the two CysLT receptors that has been cloned. Although the expression of CysLT 1 in the brain has been demonstrated by Northern blot and RT-PCR analyses, the location of CysLT 1 in the brain remains unknown. The objective of this study was to examine the distribution of CysLT 1 by immunohistochemical analysis in human brains with traumatic injury or tumors. CysLT 1 was expressed intensely in the microvascular endothelial cells in both normal and abnormal conditions. At 8 days after traumatic injury, microvascular regeneration was found and all of the endothelial cells highly expressed CysLT 1. In gray and white matters of the normal regions of the brain, CysLT 1 was expressed weekly or not at all. However, the CysLT 1 expression increased in the neuron- and glial-appearing cells in gray and white matters after traumatic brain injury. CysLT 1 was also detected in astrocytoma, ganglioglioma and metastatic adenocarcinoma, and the expression in the neuron- and glial-appearing cells around brain tumors increased robustly.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0304-3940 1872-7972
DOI:	10.1016/j.neulet.2004.03.088