Monocrotophos induced oxidative damage associates with severe acetylcholinesterase inhibition in rat brain

► Acute monocrotophos poisoning resulted in differential acetylcholinesterase inhibition in different rat brain regions. ► Neurotoxicity of monocrotophos poisoning is characterized by oxidative damage in regions of the brain that exhibit high acetylcholinesterase activity and severe acetylcholineste...

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Bibliographic Details
Published in:	Neurotoxicology (Park Forest South) Vol. 33; no. 2; pp. 156 - 161
Main Authors:	Kazi, Amajad Iqbal, Oommen, Anna
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 01.03.2012 Elsevier
Subjects:	Acetylcholinesterase Acetylcholinesterase - metabolism Analysis of Variance Animals Antioxidative enzymes Biological and medical sciences Body Weight - drug effects Brain - anatomy & histology Brain - drug effects Brain - enzymology Catalase - metabolism Cholinesterase Inhibitors - toxicity Disease Models, Animal Dose-Response Relationship, Drug Female Glutathione - metabolism Glutathione Peroxidase - metabolism Lacrimal Apparatus - drug effects Lipid peroxidation Lipid Peroxidation - drug effects Medical sciences Monocrotophos Monocrotophos - toxicity Muscle Strength - drug effects Neurotoxicity Syndromes - enzymology Neurotoxicity Syndromes - etiology Neurotoxicity Syndromes - pathology Organophosphate pesticide poisoning Oxidative stress Oxidative Stress - drug effects Pesticides, fertilizers and other agrochemicals toxicology Rats Rats, Wistar Salivation - drug effects Superoxide Dismutase - metabolism Time Factors Toxicology Lipid peroxidation Oxidative stress Monocrotophos Organophosphate pesticide poisoning Acetylcholinesterase Antioxidative enzymes Insecticide Rat Toxicity Central nervous system Lipids Esterases Encephalon Inhibition Peroxidation Enzyme Rodentia Pesticides Antioxidant Carboxylic ester hydrolases Vertebrata Mammalia Animal Hydrolases Inhibitor Poisoning Organophosphorus compounds
ISSN:	0161-813X, 1872-9711, 1872-9711
Online Access:	Get full text
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