Epithelial genetic muscarinic receptor 3 ablation induces sex-specific modulation of colonic intestinal progenitor cells and response to intestinal injury

Abstract Background & Aims Epithelial muscarinic acetylcholine receptor subtype 3 (M3R) signaling modulates intestinal stem and progenitor cell function, yet its impact on colonic homeostasis remains unclear. Hence, this study explores the sex-specific effects of epithelial genetic M3R ablation...

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Bibliographic Details
Published in:	Journal of Crohn's and colitis Vol. 19; no. 6
Main Authors:	Ragab, Mohab, Wieland, Jessica, Waldherr Avila de Melo, Caroline, Agibalova, Tatiana, Ermolova, Anastasia, Durner, Niklas, Hempel, Anneke, Heindl, Fabian, Maurer, H Carlo, Steiger, Katja, Janssen, Klaus-Peter, Tschurtschenthaler, Markus, Wang, Timothy C, Quante, Michael, Schmid, Roland M, Middelhoff, Moritz
Format:	Journal Article
Language:	English
Published:	UK Oxford University Press 04.06.2025
Subjects:	Animals Colitis - genetics Colitis - metabolism Colitis - pathology Colon - cytology Colon - metabolism Colon - pathology Disease Models, Animal Female Humans Intestinal Mucosa - cytology Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Male Mice Muscarinic Agonists - pharmacology Receptor, Muscarinic M3 - genetics Receptor, Muscarinic M3 - metabolism Receptors, G-Protein-Coupled - metabolism Sex Factors Stem Cells - metabolism epithelial muscarinic receptor 3 colonic progenitor cells colitis
ISSN:	1873-9946, 1876-4479, 1876-4479
Online Access:	Get full text
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