Astrocyte Responses Influence Local Effects of Whole‐Brain Magnetic Stimulation in Parkinsonian Rats
Background Excessive glutamatergic transmission in the striatum is implicated in Parkinson's disease (PD) progression. Astrocytes maintain glutamate homeostasis, protecting from excitotoxicity through the glutamate–aspartate transporter (GLAST), whose alterations have been reported in PD. Nonin...
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| Vydané v: | Movement disorders Ročník 38; číslo 12; s. 2173 - 2184 |
|---|---|
| Hlavní autori: | , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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Hoboken, USA
John Wiley & Sons, Inc
01.12.2023
Wiley Subscription Services, Inc |
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| ISSN: | 0885-3185, 1531-8257, 1531-8257 |
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| Abstract | Background
Excessive glutamatergic transmission in the striatum is implicated in Parkinson's disease (PD) progression. Astrocytes maintain glutamate homeostasis, protecting from excitotoxicity through the glutamate–aspartate transporter (GLAST), whose alterations have been reported in PD. Noninvasive brain stimulation using intermittent theta‐burst stimulation (iTBS) acts on striatal neurons and glia, inducing neuromodulatory effects and functional recovery in experimental parkinsonism.
Objective
Because PD is associated with altered astrocyte function, we hypothesized that acute iTBS, known to rescue striatal glutamatergic transmission, exerts regional‐ and cell‐specific effects through modulation of glial functions.
Methods
6‐Hydroxydopamine‐lesioned rats were exposed to acute iTBS, and the areas predicted to be more responsive by a biophysical, hyper‐realistic computational model that faithfully reconstructs the experimental setting were analyzed. The effects of iTBS on glial cells and motor behavior were evaluated by molecular and morphological analyses, and CatWalk and Stepping test, respectively.
Results
As predicted by the model, the hippocampus, cerebellum, and striatum displayed a marked c‐FOS activation after iTBS, with the striatum showing specific morphological and molecular changes in the astrocytes, decreased phospho‐CREB levels, and recovery of GLAST. Striatal‐dependent motor performances were also significantly improved.
Conclusion
These data uncover an unknown iTBS effect on astrocytes, advancing the understanding of the complex mechanisms involved in TMS‐mediated functional recovery. Data on numerical dosimetry, obtained with a degree of anatomical details never before considered and validated by the biological findings, provide a framework to predict the electric‐field induced in different specific brain areas and associate it with functional and molecular changes. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. |
|---|---|
| AbstractList | BackgroundExcessive glutamatergic transmission in the striatum is implicated in Parkinson's disease (PD) progression. Astrocytes maintain glutamate homeostasis, protecting from excitotoxicity through the glutamate–aspartate transporter (GLAST), whose alterations have been reported in PD. Noninvasive brain stimulation using intermittent theta‐burst stimulation (iTBS) acts on striatal neurons and glia, inducing neuromodulatory effects and functional recovery in experimental parkinsonism.ObjectiveBecause PD is associated with altered astrocyte function, we hypothesized that acute iTBS, known to rescue striatal glutamatergic transmission, exerts regional‐ and cell‐specific effects through modulation of glial functions.Methods6‐Hydroxydopamine‐lesioned rats were exposed to acute iTBS, and the areas predicted to be more responsive by a biophysical, hyper‐realistic computational model that faithfully reconstructs the experimental setting were analyzed. The effects of iTBS on glial cells and motor behavior were evaluated by molecular and morphological analyses, and CatWalk and Stepping test, respectively.ResultsAs predicted by the model, the hippocampus, cerebellum, and striatum displayed a marked c‐FOS activation after iTBS, with the striatum showing specific morphological and molecular changes in the astrocytes, decreased phospho‐CREB levels, and recovery of GLAST. Striatal‐dependent motor performances were also significantly improved.ConclusionThese data uncover an unknown iTBS effect on astrocytes, advancing the understanding of the complex mechanisms involved in TMS‐mediated functional recovery. Data on numerical dosimetry, obtained with a degree of anatomical details never before considered and validated by the biological findings, provide a framework to predict the electric‐field induced in different specific brain areas and associate it with functional and molecular changes. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. Excessive glutamatergic transmission in the striatum is implicated in Parkinson's disease (PD) progression. Astrocytes maintain glutamate homeostasis, protecting from excitotoxicity through the glutamate-aspartate transporter (GLAST), whose alterations have been reported in PD. Noninvasive brain stimulation using intermittent theta-burst stimulation (iTBS) acts on striatal neurons and glia, inducing neuromodulatory effects and functional recovery in experimental parkinsonism.BACKGROUNDExcessive glutamatergic transmission in the striatum is implicated in Parkinson's disease (PD) progression. Astrocytes maintain glutamate homeostasis, protecting from excitotoxicity through the glutamate-aspartate transporter (GLAST), whose alterations have been reported in PD. Noninvasive brain stimulation using intermittent theta-burst stimulation (iTBS) acts on striatal neurons and glia, inducing neuromodulatory effects and functional recovery in experimental parkinsonism.Because PD is associated with altered astrocyte function, we hypothesized that acute iTBS, known to rescue striatal glutamatergic transmission, exerts regional- and cell-specific effects through modulation of glial functions.OBJECTIVEBecause PD is associated with altered astrocyte function, we hypothesized that acute iTBS, known to rescue striatal glutamatergic transmission, exerts regional- and cell-specific effects through modulation of glial functions.6-Hydroxydopamine-lesioned rats were exposed to acute iTBS, and the areas predicted to be more responsive by a biophysical, hyper-realistic computational model that faithfully reconstructs the experimental setting were analyzed. The effects of iTBS on glial cells and motor behavior were evaluated by molecular and morphological analyses, and CatWalk and Stepping test, respectively.METHODS6-Hydroxydopamine-lesioned rats were exposed to acute iTBS, and the areas predicted to be more responsive by a biophysical, hyper-realistic computational model that faithfully reconstructs the experimental setting were analyzed. The effects of iTBS on glial cells and motor behavior were evaluated by molecular and morphological analyses, and CatWalk and Stepping test, respectively.As predicted by the model, the hippocampus, cerebellum, and striatum displayed a marked c-FOS activation after iTBS, with the striatum showing specific morphological and molecular changes in the astrocytes, decreased phospho-CREB levels, and recovery of GLAST. Striatal-dependent motor performances were also significantly improved.RESULTSAs predicted by the model, the hippocampus, cerebellum, and striatum displayed a marked c-FOS activation after iTBS, with the striatum showing specific morphological and molecular changes in the astrocytes, decreased phospho-CREB levels, and recovery of GLAST. Striatal-dependent motor performances were also significantly improved.These data uncover an unknown iTBS effect on astrocytes, advancing the understanding of the complex mechanisms involved in TMS-mediated functional recovery. Data on numerical dosimetry, obtained with a degree of anatomical details never before considered and validated by the biological findings, provide a framework to predict the electric-field induced in different specific brain areas and associate it with functional and molecular changes. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.CONCLUSIONThese data uncover an unknown iTBS effect on astrocytes, advancing the understanding of the complex mechanisms involved in TMS-mediated functional recovery. Data on numerical dosimetry, obtained with a degree of anatomical details never before considered and validated by the biological findings, provide a framework to predict the electric-field induced in different specific brain areas and associate it with functional and molecular changes. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. Background Excessive glutamatergic transmission in the striatum is implicated in Parkinson's disease (PD) progression. Astrocytes maintain glutamate homeostasis, protecting from excitotoxicity through the glutamate–aspartate transporter (GLAST), whose alterations have been reported in PD. Noninvasive brain stimulation using intermittent theta‐burst stimulation (iTBS) acts on striatal neurons and glia, inducing neuromodulatory effects and functional recovery in experimental parkinsonism. Objective Because PD is associated with altered astrocyte function, we hypothesized that acute iTBS, known to rescue striatal glutamatergic transmission, exerts regional‐ and cell‐specific effects through modulation of glial functions. Methods 6‐Hydroxydopamine‐lesioned rats were exposed to acute iTBS, and the areas predicted to be more responsive by a biophysical, hyper‐realistic computational model that faithfully reconstructs the experimental setting were analyzed. The effects of iTBS on glial cells and motor behavior were evaluated by molecular and morphological analyses, and CatWalk and Stepping test, respectively. Results As predicted by the model, the hippocampus, cerebellum, and striatum displayed a marked c‐FOS activation after iTBS, with the striatum showing specific morphological and molecular changes in the astrocytes, decreased phospho‐CREB levels, and recovery of GLAST. Striatal‐dependent motor performances were also significantly improved. Conclusion These data uncover an unknown iTBS effect on astrocytes, advancing the understanding of the complex mechanisms involved in TMS‐mediated functional recovery. Data on numerical dosimetry, obtained with a degree of anatomical details never before considered and validated by the biological findings, provide a framework to predict the electric‐field induced in different specific brain areas and associate it with functional and molecular changes. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. Excessive glutamatergic transmission in the striatum is implicated in Parkinson's disease (PD) progression. Astrocytes maintain glutamate homeostasis, protecting from excitotoxicity through the glutamate-aspartate transporter (GLAST), whose alterations have been reported in PD. Noninvasive brain stimulation using intermittent theta-burst stimulation (iTBS) acts on striatal neurons and glia, inducing neuromodulatory effects and functional recovery in experimental parkinsonism. Because PD is associated with altered astrocyte function, we hypothesized that acute iTBS, known to rescue striatal glutamatergic transmission, exerts regional- and cell-specific effects through modulation of glial functions. 6-Hydroxydopamine-lesioned rats were exposed to acute iTBS, and the areas predicted to be more responsive by a biophysical, hyper-realistic computational model that faithfully reconstructs the experimental setting were analyzed. The effects of iTBS on glial cells and motor behavior were evaluated by molecular and morphological analyses, and CatWalk and Stepping test, respectively. As predicted by the model, the hippocampus, cerebellum, and striatum displayed a marked c-FOS activation after iTBS, with the striatum showing specific morphological and molecular changes in the astrocytes, decreased phospho-CREB levels, and recovery of GLAST. Striatal-dependent motor performances were also significantly improved. These data uncover an unknown iTBS effect on astrocytes, advancing the understanding of the complex mechanisms involved in TMS-mediated functional recovery. Data on numerical dosimetry, obtained with a degree of anatomical details never before considered and validated by the biological findings, provide a framework to predict the electric-field induced in different specific brain areas and associate it with functional and molecular changes. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. |
| Author | Viscomi, Maria Teresa Liberti, Micaela Carducci, Filippo Colella, Micol Palacios, Daniela De Carluccio, Maria Apollonio, Francesca Lelli, Daniele Paffi, Alessandra Ghiglieri, Veronica Natale, Giuseppina |
| Author_xml | – sequence: 1 givenname: Giuseppina surname: Natale fullname: Natale, Giuseppina organization: Università Cattolica del Sacro Cuore – sequence: 2 givenname: Micol surname: Colella fullname: Colella, Micol organization: Sapienza University of Rome – sequence: 3 givenname: Maria surname: De Carluccio fullname: De Carluccio, Maria organization: IRCCS San Raffaele Pisana – sequence: 4 givenname: Daniele surname: Lelli fullname: Lelli, Daniele organization: Sapienza University of Rome – sequence: 5 givenname: Alessandra surname: Paffi fullname: Paffi, Alessandra organization: Sapienza University of Rome – sequence: 6 givenname: Filippo surname: Carducci fullname: Carducci, Filippo organization: Sapienza University of Rome – sequence: 7 givenname: Francesca surname: Apollonio fullname: Apollonio, Francesca organization: Sapienza University of Rome – sequence: 8 givenname: Daniela surname: Palacios fullname: Palacios, Daniela organization: Fondazione Policlinico Universitario Agostino Gemelli IRCCS – sequence: 9 givenname: Maria Teresa surname: Viscomi fullname: Viscomi, Maria Teresa organization: Fondazione Policlinico Universitario Agostino Gemelli IRCCS – sequence: 10 givenname: Micaela surname: Liberti fullname: Liberti, Micaela organization: Sapienza University of Rome – sequence: 11 givenname: Veronica orcidid: 0000-0003-2885-8298 surname: Ghiglieri fullname: Ghiglieri, Veronica email: veronica.ghiglieri@uniroma5.it organization: San Raffaele University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37700489$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_freeradbiomed_2024_10_284 crossref_primary_10_3390_brainsci14070695 crossref_primary_10_3390_biology13060387 crossref_primary_10_1016_j_parkreldis_2025_107314 crossref_primary_10_1109_JERM_2024_3468024 |
| Cites_doi | 10.1016/j.neuroscience.2008.04.024 10.1002/mds.28671 10.1111/ner.13025 10.1146/annurev.bioeng.9.061206.133100 10.1016/j.nbd.2015.11.022 10.3389/fncir.2016.00026 10.1016/j.brainres.2009.01.009 10.1186/s12974-016-0616-5 10.1097/00004691-200208000-00006 10.1523/JNEUROSCI.21-15-j0003.2001 10.1523/JNEUROSCI.1379-10.2011 10.1016/j.jphs.2020.07.011 10.3389/fncel.2016.00188 10.1016/S0197-0186(00)00019-X 10.1111/j.1471-4159.2007.05118.x 10.1007/s00221-009-1961-8 10.1007/s12035-013-8598-0 10.1046/j.1471-4159.2003.02128.x 10.1088/1361-6560/abcde7 10.18632/oncotarget.11587 10.1002/1098-1136(200010)32:1<1::AID-GLIA10>3.0.CO;2-W 10.1016/j.neuint.2007.03.012 10.1007/s00401-009-0619-8 10.3389/fnagi.2017.00263 10.1093/brain/awz260 10.1007/s00259-021-05640-5 10.1016/j.neuroimage.2014.04.001 10.1016/j.neuroscience.2008.08.022 10.1523/JNEUROSCI.2125-11.2011 10.1177/1073858417717660 10.1016/j.neuroimage.2019.116486 10.1093/cercor/bht023 10.3233/RNN-160708 10.1155/2015/976854 10.3389/fphar.2012.00066 10.1016/j.brs.2017.09.011 10.1002/glia.24246 10.3389/fnins.2022.807435 10.1074/jbc.M112.341867 10.1038/s41598-022-24934-8 10.1016/j.expneurol.2012.04.020 10.1002/brb3.1132 10.1016/j.clinph.2019.11.002 10.1016/j.brs.2019.09.015 10.1016/j.jneumeth.2020.108957 10.1016/j.neubiorev.2017.10.006 10.1088/0031-9155/51/20/009 10.1523/JNEUROSCI.2664-12.2012 10.1016/j.brs.2020.12.007 10.1016/j.clinph.2014.05.021 10.1016/j.neuropharm.2021.108678 10.1016/j.nbd.2022.105697 10.1016/j.bbi.2021.02.032 10.1073/pnas.0510797103 10.1002/mds.26982 10.1002/cne.21852 10.1038/s41598-023-31711-8 10.1186/s12974-020-01747-y 10.1038/s41598-020-74431-z 10.1093/brain/aws101 10.1016/j.clinph.2004.02.019 |
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| Copyright | 2023 The Authors. published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. 2023. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| Keywords | transcranial noninvasive stimulation GLAST synaptic plasticity glia parkinson's disease |
| Language | English |
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| Notes | Relevant conflicts of interest/financial disclosures or potential conflict of interest Giuseppina Natale and Micol Colella are equally first authors; Maria Teresa Viscomi, Micaela Liberti, and Veronica Ghiglieri are equally last authors. Funding agencies This work was supported by a grant from the Fresco Parkinson Institute to the New York University School of Medicine and The Marlene and Paolo Fresco Institute for Parkinson's and Movement Disorders, which were made possible with support from Marlene and Paolo Fresco (to V.G.). Università Cattolica del Sacro Cuore contributed to the funding of this research project (Linea D1 to M.T.V.). The authors have no financial conflicts of interest. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
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| References | 2017; 83 2012; 287 2002; 19 2021; 66 2020; 17 2009; 199 2014; 24 2020; 13 2008; 105 2020; 10 2017; 9 2020; 209 2021; 36 2018; 8 2012; 135 2010; 119 2020; 131 2017; 32 2017; 35 2007; 9 2016; 86 2021; 195 2008; 511 2008; 156 2008; 154 2014; 125 2023; 71 2003; 87 2022; 168 2014; 97 2023; 13 2006; 51 2017; 27 2021; 347 2011; 31 2016; 10 2014; 49 2020; 144 2007; 51 2009; 1260 2021; 94 2012; 32 2022; 49 2016; 13 2019; 142 2018; 24 2001; 21 2021; 14 2016; 7 2004; 115 2012; 3 2023 2000; 37 2000; 32 2022; 12 2015 2020; 23 2012; 236 2018; 11 1993; 116 2022; 16 2006; 103 e_1_2_10_23_1 e_1_2_10_46_1 e_1_2_10_21_1 e_1_2_10_44_1 e_1_2_10_42_1 e_1_2_10_40_1 e_1_2_10_2_1 e_1_2_10_4_1 e_1_2_10_18_1 e_1_2_10_53_1 e_1_2_10_6_1 e_1_2_10_16_1 e_1_2_10_39_1 e_1_2_10_55_1 e_1_2_10_8_1 e_1_2_10_14_1 e_1_2_10_57_1 e_1_2_10_58_1 e_1_2_10_13_1 e_1_2_10_11_1 e_1_2_10_32_1 e_1_2_10_30_1 e_1_2_10_51_1 Calabresi P (e_1_2_10_52_1) 1993; 116 e_1_2_10_61_1 e_1_2_10_29_1 e_1_2_10_63_1 e_1_2_10_27_1 e_1_2_10_65_1 e_1_2_10_25_1 e_1_2_10_48_1 e_1_2_10_24_1 e_1_2_10_45_1 e_1_2_10_22_1 e_1_2_10_43_1 e_1_2_10_20_1 e_1_2_10_41_1 Bungert A (e_1_2_10_37_1) 2017; 27 e_1_2_10_3_1 e_1_2_10_19_1 e_1_2_10_54_1 e_1_2_10_5_1 e_1_2_10_17_1 e_1_2_10_38_1 e_1_2_10_56_1 e_1_2_10_7_1 e_1_2_10_15_1 e_1_2_10_36_1 e_1_2_10_12_1 e_1_2_10_35_1 e_1_2_10_9_1 e_1_2_10_59_1 e_1_2_10_10_1 e_1_2_10_33_1 e_1_2_10_31_1 e_1_2_10_50_1 Leergaard TB (e_1_2_10_34_1) 2023 e_1_2_10_60_1 e_1_2_10_62_1 e_1_2_10_64_1 e_1_2_10_28_1 e_1_2_10_49_1 e_1_2_10_26_1 e_1_2_10_47_1 |
| References_xml | – volume: 13 start-page: 157 issue: 1 year: 2020 end-page: 166 article-title: Conditions for numerically accurate TMS electric field simulation publication-title: Brain Stimul – volume: 32 start-page: 17921 issue: 49 year: 2012 end-page: 17931 article-title: Rebalance of striatal NMDA/AMPA receptor ratio underlies the reduced emergence of dyskinesia during D2‐like dopamine agonist treatment in experimental Parkinson's disease publication-title: J Neurosci – volume: 1260 start-page: 94 year: 2009 end-page: 99 article-title: The effects of chronic repetitive transcranial magnetic stimulation on glutamate and gamma‐aminobutyric acid in rat brain publication-title: Brain Res – volume: 347 year: 2021 article-title: Non‐invasive brain stimulation for Parkinson's disease: clinical evidence, latest concepts and future goals: a systematic review publication-title: J Neurosci Methods – volume: 125 start-page: 2150 issue: 11 year: 2014 end-page: 2206 article-title: Evidence‐based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS) publication-title: Clin Neurophysiol – volume: 14 start-page: 183 issue: 1 year: 2021 end-page: 191 article-title: Low intensity repetitive magnetic stimulation reduces expression of genes related to inflammation and calcium signalling in cultured mouse cortical astrocytes publication-title: Brain Stimul – start-page: 1 year: 2015 end-page: 11 article-title: A computational model for real‐time calculation of electric field due to transcranial magnetic stimulation in clinics publication-title: Int J Antennas Propagation – volume: 142 start-page: 3116 issue: 10 year: 2019 end-page: 3128 article-title: Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson's disease: an in vivo11C‐BU99008 PET study publication-title: Brain – volume: 49 start-page: 1282 issue: 3 year: 2014 end-page: 1292 article-title: Ceftriaxone increases glutamate uptake and reduces striatal tyrosine hydroxylase loss in 6‐OHDA Parkinson's model publication-title: Mol Neurobiol – volume: 31 start-page: 1193 issue: 4 year: 2011 end-page: 1203 article-title: Theta‐burst transcranial magnetic stimulation alters cortical inhibition publication-title: J Neurosci – volume: 17 start-page: 150 issue: 1 year: 2020 article-title: High‐frequency repetitive transcranial magnetic stimulation improves functional recovery by inhibiting neurotoxic polarization of astrocytes in ischemic rats publication-title: J Neuroinflammation – volume: 24 start-page: 1697 issue: 7 year: 2014 end-page: 1707 article-title: Network connectivity and individual responses to brain stimulation in the human motor system publication-title: Cereb Cortex – volume: 168 year: 2022 article-title: Striatal glutamatergic hyperactivity in Parkinson's disease publication-title: Neurobiol Dis – volume: 511 start-page: 421 issue: 4 year: 2008 end-page: 437 article-title: Downregulation of glial glutamate transporters after dopamine denervation in the striatum of 6‐hydroxydopamine‐lesioned rats publication-title: J Comp Neurol – volume: 87 start-page: 1485 issue: 6 year: 2003 end-page: 1498 article-title: Transcriptional regulation of human excitatory amino acid transporter 1 (EAAT1): cloning of the EAAT1 promoter and characterization of its basal and inducible activity in human astrocytes publication-title: J Neurochem – volume: 24 start-page: 246 issue: 3 year: 2018 end-page: 260 article-title: Noninvasive stimulation of the human brain: activation of multiple cortical circuits publication-title: Neuroscientist – volume: 8 issue: 11 year: 2018 article-title: Repetitive transcranial magnetic stimulation therapy for motor recovery in Parkinson's disease: a meta‐analysis publication-title: Brain Behav – volume: 36 start-page: 2254 issue: 10 year: 2021 end-page: 2263 article-title: Transcranial magnetic stimulation exerts "rejuvenation" effects on Corticostriatal synapses after partial dopamine depletion publication-title: Mov Disord – volume: 287 start-page: 26817 issue: 32 year: 2012 end-page: 26828 article-title: GPR30 regulates glutamate transporter GLT‐1 expression in rat primary astrocytes publication-title: J Biol Chem – volume: 51 start-page: 5211 issue: 20 year: 2006 end-page: 5229 article-title: Development of novel whole‐body exposure setups for rats providing high efficiency, National Toxicology Program (NTP) compatibility and well‐characterized exposure publication-title: Phys Med Biol – volume: 209 year: 2020 article-title: A novel approach to localize cortical TMS effects publication-title: Neuroimage – volume: 10 start-page: 26 year: 2016 article-title: How does transcranial magnetic stimulation influence glial cells in the central nervous system? publication-title: Front Neural Circuits – volume: 3 start-page: 66 year: 2012 article-title: Endocannabinoid‐dopamine interactions in striatal synaptic plasticity publication-title: Front Pharmacol – volume: 71 start-page: 44 issue: 1 year: 2023 end-page: 59 article-title: Endocannabinoid signaling in astrocytes publication-title: Glia – volume: 83 start-page: 381 year: 2017 end-page: 404 article-title: Transcranial magnetic stimulation in basic and clinical neuroscience: a comprehensive review of fundamental principles and novel insights publication-title: Neurosci Biobehav Rev – volume: 51 start-page: 333 issue: 6–7 year: 2007 end-page: 355 article-title: The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention publication-title: Neurochem Int – volume: 35 start-page: 557 issue: 6 year: 2017 end-page: 569 article-title: Frequency‐specific effects of repetitive magnetic stimulation on primary astrocyte cultures publication-title: Restor Neurol Neurosci – volume: 32 start-page: 1035 issue: 7 year: 2017 end-page: 1046 article-title: Intermittent theta‐burst stimulation rescues dopamine‐dependent corticostriatal synaptic plasticity and motor behavior in experimental parkinsonism: possible role of glial activity publication-title: Mov Disord – volume: 12 start-page: 20571 issue: 1 year: 2022 article-title: Low intensity repetitive transcranial magnetic stimulation modulates brain‐wide functional connectivity to promote anti‐correlated c‐Fos expression publication-title: Sci Rep – volume: 16 year: 2022 article-title: Imaging of reactive astrogliosis by positron emission tomography publication-title: Front Neurosci – volume: 7 start-page: 58802 issue: 37 year: 2016 end-page: 58812 article-title: Repetitive transcranial magnetic stimulation (rTMS) improves behavioral and biochemical deficits in levodopa‐induced dyskinetic rats model publication-title: Oncotarget – volume: 236 start-page: 395 issue: 2 year: 2012 end-page: 398 article-title: Θ‐burst stimulation and striatal plasticity in experimental parkinsonism publication-title: Exp Neurol – volume: 13 start-page: 150 issue: 1 year: 2016 article-title: Repetitive transcranial magnetic stimulation reduces remote apoptotic cell death and inflammation after focal brain injury publication-title: J Neuroinflammation – volume: 21 start-page: RC157 issue: 15 year: 2001 article-title: Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleus publication-title: J Neurosci – volume: 11 start-page: 166 issue: 1 year: 2018 end-page: 174 article-title: Where and what TMS activates: experiments and modeling publication-title: Brain Stimul – volume: 154 start-page: 1267 issue: 4 year: 2008 end-page: 1282 article-title: Methylprednisolone treatment delays remote cell death after focal brain lesion publication-title: Neuroscience – volume: 86 start-page: 140 year: 2016 end-page: 153 article-title: Modulation of serotonergic transmission by eltoprazine in L‐DOPA‐induced dyskinesia: behavioral, molecular, and synaptic mechanisms publication-title: Neurobiol Dis – volume: 115 start-page: 1697 issue: 7 year: 2004 end-page: 1708 article-title: Electric field properties of two commercial figure‐8 coils in TMS: calculation of focality and efficiency publication-title: Clin Neurophysiol – volume: 9 start-page: 527 year: 2007 end-page: 565 article-title: Noninvasive human brain stimulation publication-title: Annu Rev Biomed Eng – volume: 94 start-page: 89 year: 2021 end-page: 103 article-title: Early life stress exposure worsens adult remote microglia activation, neuronal death, and functional recovery after focal brain injury publication-title: Brain Behav Immun – volume: 116 start-page: 433 issue: 2 year: 1993 end-page: 452 article-title: Electrophysiology of dopamine‐denervated striatal neurons publication-title: Implicat Parkinson's Dis Brain – volume: 37 start-page: 163 issue: 2–3 year: 2000 end-page: 170 article-title: The high‐affinity glutamate transporters GLT1, GLAST, and EAAT4 are regulated via different signalling mechanisms publication-title: Neurochem Int – volume: 13 start-page: 4671 issue: 1 year: 2023 article-title: Quartile coefficient of variation is more robust than CV for traits calculated as a ratio publication-title: Sci Rep – volume: 49 start-page: 1275 issue: 4 year: 2022 end-page: 1287 article-title: PET imaging of reactive astrocytes in neurological disorders publication-title: Eur J Nucl Med Mol Imaging – volume: 66 issue: 3 year: 2021 article-title: Effect of skin conductivity on the electric field induced by transcranial stimulation techniques in different head models publication-title: Phys Med Biol – volume: 144 start-page: 151 issue: 3 year: 2020 end-page: 164 article-title: Glutamate‐induced excitotoxicity in Parkinson's disease: the role of glial cells publication-title: J Pharmacol Sci – volume: 10 start-page: 17397 issue: 1 year: 2020 article-title: Individual head models for estimating the TMS‐induced electric field in rat brain publication-title: Sci Rep – volume: 10 start-page: 188 year: 2016 article-title: Glia: a neglected player in non‐invasive direct current brain stimulation publication-title: Front Cell Neurosci – volume: 23 start-page: 324 issue: 3 year: 2020 end-page: 334 article-title: Design and evaluation of a rodent‐specific transcranial magnetic stimulation coil: an In Silico and In vivo validation study publication-title: Neuromodulation – volume: 119 start-page: 7 issue: 1 year: 2010 end-page: 35 article-title: Astrocytes: biology and pathology publication-title: Acta Neuropathol – volume: 97 start-page: 374 year: 2014 end-page: 386 article-title: Waxholm space atlas of the Sprague Dawley rat brain publication-title: Neuroimage – volume: 199 start-page: 411 issue: 3–4 year: 2009 end-page: 421 article-title: θ burst and conventional low‐frequency rTMS differentially affect GABAergic neurotransmission in the rat cortex publication-title: Exp Brain Res – volume: 32 start-page: 1 issue: 1 year: 2000 end-page: 14 article-title: Astrocyte glutamate transport: review of properties, regulation, and physiological functions publication-title: Glia – volume: 9 start-page: 263 year: 2017 article-title: Reproducibility of single‐pulse, paired‐pulse, and intermittent theta‐burst TMS measures in healthy aging, Type‐2 diabetes, and Alzheimer's disease publication-title: Front Aging Neurosci – year: 2023 article-title: Waxholm space atlas of the rat brain: a 3D atlas supporting data analysis and integration publication-title: Research Square – volume: 105 start-page: 137 issue: 1 year: 2008 end-page: 150 article-title: Inhibitory regulation of glutamate aspartate transporter (GLAST) expression in astrocytes by cadmium‐induced calcium influx publication-title: J Neurochem – volume: 19 start-page: 322 issue: 4 year: 2002 end-page: 343 article-title: Basic mechanisms of TMS publication-title: J Clin Neurophysiol – volume: 135 start-page: 1884 issue: 6 year: 2012 end-page: 1899 article-title: Mechanisms underlying the impairment of hippocampal long‐term potentiation and memory in experimental Parkinson's disease publication-title: Brain – volume: 103 start-page: 8251 issue: 21 year: 2006 end-page: 8256 article-title: Frequency‐specific and D2 receptor‐mediated inhibition of glutamate release by retrograde endocannabinoid signaling publication-title: Proc Natl Acad Sci U S A – volume: 131 start-page: 474 issue: 2 year: 2020 end-page: 528 article-title: Evidence‐based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): an update (2014‐2018) publication-title: Clin Neurophysiol – volume: 27 start-page: 5083 issue: 11 year: 2017 end-page: 5094 article-title: Where does TMS stimulate the motor cortex? Combining electrophysiological measurements and realistic field estimates to reveal the affected cortex position publication-title: Cereb Cortex – volume: 195 year: 2021 article-title: CB1R‐dependent regulation of astrocyte physiology and astrocyte‐neuron interactions publication-title: Neuropharmacology – volume: 156 start-page: 898 issue: 4 year: 2008 end-page: 910 article-title: Amyloid‐beta peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and mitogen‐activated protein kinase cascades publication-title: Neuroscience – volume: 31 start-page: 11044 issue: 30 year: 2011 end-page: 11054 article-title: Repetitive transcranial magnetic stimulation enhances BDNF‐TrkB signaling in both brain and lymphocyte publication-title: J Neurosci – ident: e_1_2_10_42_1 doi: 10.1016/j.neuroscience.2008.04.024 – ident: e_1_2_10_15_1 doi: 10.1002/mds.28671 – ident: e_1_2_10_62_1 doi: 10.1111/ner.13025 – ident: e_1_2_10_4_1 doi: 10.1146/annurev.bioeng.9.061206.133100 – ident: e_1_2_10_41_1 doi: 10.1016/j.nbd.2015.11.022 – ident: e_1_2_10_21_1 doi: 10.3389/fncir.2016.00026 – ident: e_1_2_10_13_1 doi: 10.1016/j.brainres.2009.01.009 – volume: 116 start-page: 433 issue: 2 year: 1993 ident: e_1_2_10_52_1 article-title: Electrophysiology of dopamine‐denervated striatal neurons publication-title: Implicat Parkinson's Dis Brain – ident: e_1_2_10_48_1 doi: 10.1186/s12974-016-0616-5 – ident: e_1_2_10_2_1 doi: 10.1097/00004691-200208000-00006 – ident: e_1_2_10_10_1 doi: 10.1523/JNEUROSCI.21-15-j0003.2001 – ident: e_1_2_10_19_1 doi: 10.1523/JNEUROSCI.1379-10.2011 – ident: e_1_2_10_30_1 doi: 10.1016/j.jphs.2020.07.011 – ident: e_1_2_10_22_1 doi: 10.3389/fncel.2016.00188 – ident: e_1_2_10_58_1 doi: 10.1016/S0197-0186(00)00019-X – ident: e_1_2_10_60_1 doi: 10.1111/j.1471-4159.2007.05118.x – ident: e_1_2_10_18_1 doi: 10.1007/s00221-009-1961-8 – ident: e_1_2_10_28_1 doi: 10.1007/s12035-013-8598-0 – ident: e_1_2_10_59_1 doi: 10.1046/j.1471-4159.2003.02128.x – ident: e_1_2_10_35_1 doi: 10.1088/1361-6560/abcde7 – ident: e_1_2_10_17_1 doi: 10.18632/oncotarget.11587 – ident: e_1_2_10_26_1 doi: 10.1002/1098-1136(200010)32:1<1::AID-GLIA10>3.0.CO;2-W – volume: 27 start-page: 5083 issue: 11 year: 2017 ident: e_1_2_10_37_1 article-title: Where does TMS stimulate the motor cortex? Combining electrophysiological measurements and realistic field estimates to reveal the affected cortex position publication-title: Cereb Cortex – ident: e_1_2_10_27_1 doi: 10.1016/j.neuint.2007.03.012 – ident: e_1_2_10_25_1 doi: 10.1007/s00401-009-0619-8 – ident: e_1_2_10_8_1 doi: 10.3389/fnagi.2017.00263 – ident: e_1_2_10_64_1 doi: 10.1093/brain/awz260 – ident: e_1_2_10_65_1 doi: 10.1007/s00259-021-05640-5 – ident: e_1_2_10_33_1 doi: 10.1016/j.neuroimage.2014.04.001 – ident: e_1_2_10_49_1 doi: 10.1016/j.neuroscience.2008.08.022 – ident: e_1_2_10_16_1 doi: 10.1523/JNEUROSCI.2125-11.2011 – ident: e_1_2_10_9_1 doi: 10.1177/1073858417717660 – ident: e_1_2_10_39_1 doi: 10.1016/j.neuroimage.2019.116486 – ident: e_1_2_10_5_1 doi: 10.1093/cercor/bht023 – ident: e_1_2_10_20_1 doi: 10.3233/RNN-160708 – year: 2023 ident: e_1_2_10_34_1 article-title: Waxholm space atlas of the rat brain: a 3D atlas supporting data analysis and integration publication-title: Research Square – ident: e_1_2_10_40_1 doi: 10.1155/2015/976854 – ident: e_1_2_10_54_1 doi: 10.3389/fphar.2012.00066 – ident: e_1_2_10_38_1 doi: 10.1016/j.brs.2017.09.011 – ident: e_1_2_10_57_1 doi: 10.1002/glia.24246 – ident: e_1_2_10_63_1 doi: 10.3389/fnins.2022.807435 – ident: e_1_2_10_50_1 doi: 10.1074/jbc.M112.341867 – ident: e_1_2_10_46_1 doi: 10.1038/s41598-022-24934-8 – ident: e_1_2_10_31_1 doi: 10.1016/j.expneurol.2012.04.020 – ident: e_1_2_10_12_1 doi: 10.1002/brb3.1132 – ident: e_1_2_10_3_1 doi: 10.1016/j.clinph.2019.11.002 – ident: e_1_2_10_45_1 doi: 10.1016/j.brs.2019.09.015 – ident: e_1_2_10_11_1 doi: 10.1016/j.jneumeth.2020.108957 – ident: e_1_2_10_6_1 doi: 10.1016/j.neubiorev.2017.10.006 – ident: e_1_2_10_32_1 doi: 10.1088/0031-9155/51/20/009 – ident: e_1_2_10_51_1 doi: 10.1523/JNEUROSCI.2664-12.2012 – ident: e_1_2_10_23_1 doi: 10.1016/j.brs.2020.12.007 – ident: e_1_2_10_7_1 doi: 10.1016/j.clinph.2014.05.021 – ident: e_1_2_10_56_1 doi: 10.1016/j.neuropharm.2021.108678 – ident: e_1_2_10_53_1 doi: 10.1016/j.nbd.2022.105697 – ident: e_1_2_10_43_1 doi: 10.1016/j.bbi.2021.02.032 – ident: e_1_2_10_55_1 doi: 10.1073/pnas.0510797103 – ident: e_1_2_10_14_1 doi: 10.1002/mds.26982 – ident: e_1_2_10_29_1 doi: 10.1002/cne.21852 – ident: e_1_2_10_44_1 doi: 10.1038/s41598-023-31711-8 – ident: e_1_2_10_24_1 doi: 10.1186/s12974-020-01747-y – ident: e_1_2_10_61_1 doi: 10.1038/s41598-020-74431-z – ident: e_1_2_10_47_1 doi: 10.1093/brain/aws101 – ident: e_1_2_10_36_1 doi: 10.1016/j.clinph.2004.02.019 |
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Excessive glutamatergic transmission in the striatum is implicated in Parkinson's disease (PD) progression. Astrocytes maintain glutamate... Excessive glutamatergic transmission in the striatum is implicated in Parkinson's disease (PD) progression. Astrocytes maintain glutamate homeostasis,... BackgroundExcessive glutamatergic transmission in the striatum is implicated in Parkinson's disease (PD) progression. Astrocytes maintain glutamate... |
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| SubjectTerms | Astrocytes Basal ganglia Central nervous system diseases Cerebellum Computational neuroscience Cyclic AMP response element-binding protein Dosimetry Excitotoxicity GLAST glia Glial cells Glutamatergic transmission Homeostasis Magnetic fields Morphology Movement disorders Neostriatum Neurodegenerative diseases Neuronal-glial interactions Parkinson's disease Recovery of function synaptic plasticity transcranial noninvasive stimulation |
| Title | Astrocyte Responses Influence Local Effects of Whole‐Brain Magnetic Stimulation in Parkinsonian Rats |
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