Effect of quadrantwise versus full‐mouth subgingival instrumentation on clinical and microbiological parameters in periodontitis patients: A randomized clinical trial

Aim This study evaluated the efficacy of quadrantwise subgingival instrumentation (Q‐SI) versus one‐stage full‐mouth subgingival instrumentation (FM‐SI) on probing depth and periodontal pathogen reduction over a 6‐month follow‐up period, as well as whether baseline periodontal pathogens influenced t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of periodontal research Jg. 59; H. 4; S. 647 - 656
Hauptverfasser: Isola, Gaetano, Polizzi, Alessandro, Santonocito, Simona, Alibrandi, Angela, Pesce, Paolo, Kocher, Thomas
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Wiley Subscription Services, Inc 01.08.2024
Schlagworte:
Adult
Aggregatibacter actinomycetemcomitans - isolation & purification
Bacterial Load
biofilm
clinical trial
dental prophylaxis
Dental Scaling - instrumentation
Dental Scaling - methods
Female
Follow-Up Studies
Gingiva
Gum disease
Humans
Hygiene
Male
Middle Aged
Mouth
Oral Hygiene
Pathogens
Patients
Periodontal Attachment Loss - microbiology
Periodontal Index
periodontal instrumentation
Periodontal Pocket - microbiology
periodontal therapy
Periodontitis
Periodontitis - microbiology
Periodontitis - therapy
Porphyromonas gingivalis - isolation & purification
Real-Time Polymerase Chain Reaction
Statistical analysis
Tannerella forsythia - isolation & purification
Treatment Outcome
clinical trial
dental prophylaxis
periodontal therapy
periodontal instrumentation
biofilm
periodontitis
ISSN:0022-3484, 1600-0765, 1600-0765
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Aim This study evaluated the efficacy of quadrantwise subgingival instrumentation (Q‐SI) versus one‐stage full‐mouth subgingival instrumentation (FM‐SI) on probing depth and periodontal pathogen reduction over a 6‐month follow‐up period, as well as whether baseline periodontal pathogens influenced the impact of periodontal treatment protocols on outcomes. Methods Patients with periodontitis were randomized to receive Q‐SI (n = 43) or FM‐SI (n = 45). Patients were instructed and motivated to maintain optimal oral hygiene during the treatment sessions. Clinical (probing pocket depth [PPD], clinical attachment loss [CAL], and bleeding on probing [BOP]) and periodontal pathogens were assessed at baseline and after 30, 90, and 180 days. Total bacterial load and periodontal pathogens were analysed via real‐time PCR. Results At the 6‐month follow‐up, the median PPD decreased from 4.8 mm (interquartile range [IQR]: 4.3–5.2) to 2.6 mm (IQR: 2.3–2.9) in FM‐SI patients and from 4.7 mm (IQR: 4.1–5.2) to 3.2 mm (IQR: 2.4–3.5) in Q‐SI patients (p < .001). At 6 months, FM‐SI was more effective at reducing the median proportions of Porphyromonas gingivalis (Pg), Aggregatibacter actinocomyctemcomitans, and Tannerella forsythia (Tf) (p < .001 for each value). Multilevel linear regression analysis demonstrated that high baseline PPD (p = .029), Pg (p = .014), and Tf (p < .001) levels and the FM‐SI protocol (p < .001) were statistically significant predictors of PPD reduction at 6 months. Furthermore, PPD reduction was significantly greater in the FM‐SI group when lower baseline Pg levels were detected. Conclusion The FM‐SI was more effective than the Q‐SI in reducing the mean PPD and number of periodontal pathogens in periodontitis patients over a 6‐month follow‐up period. Higher baseline PPD and Pg levels had a negative impact on PPD reduction at 6 months after FM‐SI.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ObjectType-Undefined-3
ISSN:0022-3484
1600-0765
1600-0765
DOI:10.1111/jre.13279