BMP6 and VDR gene polymorphisms are associated with osteonecrosis in a sickle cell anaemia cohort

Summary The occurrence and severity of osteonecrosis in sickle cell anaemia (SCA) vary due to risk factors, including genetic modifiers. Bone morphogenetic proteins (BMPs), particularly BMP6, and the vitamin D receptor (VDR) play key roles in cartilage and bone metabolism, making them potential cont...

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Veröffentlicht in:	British journal of haematology Jg. 204; H. 4; S. 1507 - 1514
Hauptverfasser:	Arcanjo, Gabriela S., Souza, Mariana B., Domingos, Igor F., Pereira‐Martins, Diego A., Falcão, Diego A., Batista, Jessica V., Hatzlhofer, Betania L., Diniz, Madi V., Silva, Alexsandro P., Guaraná, Werbson L., Hazin, Manuela F., Araujo, Aderson S., Cunha, Anderson F., Saad, Sara O., Costa, Fernando F., Lucena‐Araujo, Antonio R., Bezerra, Marcos André C.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Blackwell Publishing Ltd 01.04.2024
Schlagworte:	Anemia avascular necrosis Bone morphogenetic protein 6 Bone morphogenetic proteins bone morphogenic proteins Bone turnover CDX2 protein Gene polymorphism Necrosis Osteonecrosis Risk factors rs3812163 Sickle cell anemia Sickle cell disease vitamin D receptor Vitamin D receptors rs3812163 vitamin D receptor avascular necrosis bone morphogenic proteins sickle cell disease
ISSN:	0007-1048, 1365-2141, 1365-2141
Online-Zugang:	Volltext
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