Oocyte aging in a marine protostome worm: The roles of maturation‐promoting factor and extracellular signal regulated kinase form of mitogen‐activated protein kinase

The roles of maturation‐promoting factor (MPF) and an extracellular signal regulated kinase form of mitogen‐activated protein kinase (ERK MAPK) are analyzed during oocyte aging in the marine protostome worm Cerebratulus. About a day after removal from the ovary, unfertilized metaphase‐I‐arrested ooc...

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Published in:	Development, growth & differentiation Vol. 58; no. 3; pp. 250 - 259
Main Authors:	Stricker, Stephen A., Beckstrom, Bradley, Mendoza, Cristina, Stanislawski, Emma, Wodajo, Tewodros
Format:	Journal Article
Language:	English
Published:	Japan Wiley Subscription Services, Inc 01.04.2016
Subjects:	Animals apoptosis Apoptosis - physiology Butadienes - pharmacology Cells, Cultured Cellular Senescence - drug effects Cellular Senescence - physiology Cerebratulus Colforsin - pharmacology Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - metabolism Female Immunoblotting Invertebrates - cytology Invertebrates - drug effects Invertebrates - metabolism Kinases Maturation-Promoting Factor - antagonists & inhibitors Maturation-Promoting Factor - metabolism necroptosis nemertean Nitriles - pharmacology non‐apoptotic regulated cell death Oocytes - cytology Oocytes - drug effects Oocytes - physiology Protein Kinase Inhibitors - pharmacology Purines - pharmacology Seawater - parasitology Time Factors Vasodilator Agents apoptosis nemertean Cerebratulus non-apoptotic regulated cell death necroptosis
ISSN:	0012-1592, 1440-169X
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Abstract	The roles of maturation‐promoting factor (MPF) and an extracellular signal regulated kinase form of mitogen‐activated protein kinase (ERK MAPK) are analyzed during oocyte aging in the marine protostome worm Cerebratulus. About a day after removal from the ovary, unfertilized metaphase‐I‐arrested oocytes of Cerebratulus begin to flatten and swell before eventually lysing, thereby exhibiting characteristics of a necroptotic mode of regulated cell death. Based on immunoblots probed with phospho‐specific antibodies, MPF and ERK are initially active in freshly mature specimens. However, as oocytes age, both kinase activities decline, with ERK deactivation occurring well before MPF downregulation. Experiments using pharmacological modulators indicate that oocyte degradation is promoted by the maturation‐initiated activation of ERK as well as by the deactivation of MPF that occurs in extensively aged specimens. The potential significance of these findings is discussed relative to previously published results for apoptotic eggs and oocytes of echinoderm and vertebrate deuterostomes. To supplement studies of other oocytes, morphological patterns of extraovarian aging are described for metaphase‐I‐arrested oocytes produced by Cerebratulus, an externally fertilizing marine worm of the phylum Nemertea. In addition, pharmacological modulators are combined with immunoblotting assays to provide data for this protostome that can be compared with previous reports for echinoderm and vertebrate deuterostomes.
AbstractList	The roles of maturation-promoting factor (MPF) and an extracellular signal regulated kinase form of mitogen-activated protein kinase (ERK MAPK) are analyzed during oocyte aging in the marine protostome worm Cerebratulus. About a day after removal from the ovary, unfertilized metaphase-I-arrested oocytes of Cerebratulus begin to flatten and swell before eventually lysing, thereby exhibiting characteristics of a necroptotic mode of regulated cell death. Based on immunoblots probed with phospho-specific antibodies, MPF and ERK are initially active in freshly mature specimens. However, as oocytes age, both kinase activities decline, with ERK deactivation occurring well before MPF downregulation. Experiments using pharmacological modulators indicate that oocyte degradation is promoted by the maturation-initiated activation of ERK as well as by the deactivation of MPF that occurs in extensively aged specimens. The potential significance of these findings is discussed relative to previously published results for apoptotic eggs and oocytes of echinoderm and vertebrate deuterostomes. The roles of maturation‐promoting factor ( MPF ) and an extracellular signal regulated kinase form of mitogen‐activated protein kinase ( ERK MAPK ) are analyzed during oocyte aging in the marine protostome worm Cerebratulus . About a day after removal from the ovary, unfertilized metaphase‐I‐arrested oocytes of Cerebratulus begin to flatten and swell before eventually lysing, thereby exhibiting characteristics of a necroptotic mode of regulated cell death. Based on immunoblots probed with phospho‐specific antibodies, MPF and ERK are initially active in freshly mature specimens. However, as oocytes age, both kinase activities decline, with ERK deactivation occurring well before MPF downregulation. Experiments using pharmacological modulators indicate that oocyte degradation is promoted by the maturation‐initiated activation of ERK as well as by the deactivation of MPF that occurs in extensively aged specimens. The potential significance of these findings is discussed relative to previously published results for apoptotic eggs and oocytes of echinoderm and vertebrate deuterostomes. The roles of maturation‐promoting factor (MPF) and an extracellular signal regulated kinase form of mitogen‐activated protein kinase (ERK MAPK) are analyzed during oocyte aging in the marine protostome worm Cerebratulus. About a day after removal from the ovary, unfertilized metaphase‐I‐arrested oocytes of Cerebratulus begin to flatten and swell before eventually lysing, thereby exhibiting characteristics of a necroptotic mode of regulated cell death. Based on immunoblots probed with phospho‐specific antibodies, MPF and ERK are initially active in freshly mature specimens. However, as oocytes age, both kinase activities decline, with ERK deactivation occurring well before MPF downregulation. Experiments using pharmacological modulators indicate that oocyte degradation is promoted by the maturation‐initiated activation of ERK as well as by the deactivation of MPF that occurs in extensively aged specimens. The potential significance of these findings is discussed relative to previously published results for apoptotic eggs and oocytes of echinoderm and vertebrate deuterostomes. To supplement studies of other oocytes, morphological patterns of extraovarian aging are described for metaphase‐I‐arrested oocytes produced by Cerebratulus, an externally fertilizing marine worm of the phylum Nemertea. In addition, pharmacological modulators are combined with immunoblotting assays to provide data for this protostome that can be compared with previous reports for echinoderm and vertebrate deuterostomes.
Author	Beckstrom, Bradley Stanislawski, Emma Stricker, Stephen A. Mendoza, Cristina Wodajo, Tewodros
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References	2010; 11 2015; 37 2006; 74 2007; 303 2006; 73 2013; 23 2004; 67 2005; 579 2012; 19 1999; 126 2014; 450 2013; 9 2010; 22 2009; 55 2013; 14 2003; 206 2000; 17 2010; 277 1997; 56 1987 2007; 8 2000; 60 1998; 202 2014; 19 2005; 70 1996; 176 2000; 287 1961; 48 2009; 15 2013; 1833 2010; 77 2000; 63 2008; 15 2013; 224 2000; 351 2008; 10 2003; 30 2011; 8 2010; 40 2009; 138 2003; 130 2010; 45 2015; 23 2014; 81 2009; 76 2002; 62 2002; 124 2015; 20 2004; 15 2015; 22 2000; 182 1995; 105 2015; 517 2014 1999; 276 2011; 49 2005; 12 2006; 300 2001; 237 2011; 142 e_1_2_6_51_1 e_1_2_6_53_1 e_1_2_6_32_1 e_1_2_6_30_1 e_1_2_6_19_1 e_1_2_6_13_1 e_1_2_6_59_1 e_1_2_6_11_1 e_1_2_6_34_1 e_1_2_6_17_1 e_1_2_6_55_1 e_1_2_6_15_1 e_1_2_6_38_1 e_1_2_6_57_1 e_1_2_6_62_1 Lemasters J. J. (e_1_2_6_24_1) 1999; 276 e_1_2_6_20_1 e_1_2_6_41_1 e_1_2_6_60_1 e_1_2_6_9_1 e_1_2_6_5_1 e_1_2_6_7_1 e_1_2_6_49_1 e_1_2_6_3_1 e_1_2_6_22_1 Stricker S. A. (e_1_2_6_43_1) 1987 e_1_2_6_28_1 e_1_2_6_45_1 e_1_2_6_26_1 e_1_2_6_47_1 e_1_2_6_52_1 Romano G. (e_1_2_6_36_1) 2003; 206 e_1_2_6_54_1 e_1_2_6_10_1 e_1_2_6_31_1 e_1_2_6_50_1 Gumienny T. L. (e_1_2_6_16_1) 1999; 126 e_1_2_6_14_1 e_1_2_6_35_1 e_1_2_6_12_1 e_1_2_6_33_1 e_1_2_6_18_1 e_1_2_6_39_1 e_1_2_6_56_1 e_1_2_6_37_1 e_1_2_6_58_1 e_1_2_6_63_1 e_1_2_6_42_1 e_1_2_6_21_1 e_1_2_6_40_1 e_1_2_6_61_1 e_1_2_6_8_1 e_1_2_6_4_1 e_1_2_6_6_1 e_1_2_6_25_1 e_1_2_6_48_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_29_1 e_1_2_6_44_1 e_1_2_6_27_1 e_1_2_6_46_1
References_xml	– volume: 142 start-page: 1 year: 2011 end-page: 12 article-title: Potential upstream regulators and downstream targets of AMP‐activated kinase signaling during oocyte maturation in a marine worm publication-title: Reproduction – volume: 206 start-page: 3487 year: 2003 end-page: 3494 article-title: A marine diatom‐derived aldehyde induces apoptosis in copepod and sea urchin embryos publication-title: J. Exp. Biol. – volume: 237 start-page: 18 year: 2001 end-page: 28 article-title: Fertilization blocks apoptosis of starfish eggs by inactivation of the MAP kinase pathway publication-title: Dev. Biol. – volume: 55 start-page: 75 year: 2009 end-page: 82 article-title: The roles of c‐Jun N‐terminal kinase (JNK) and p38 mitogen‐activated protein kinase (p38 MAPK) in aged pig oocytes publication-title: J. Reprod. Dev. – volume: 60 start-page: 553 year: 2000 end-page: 561 article-title: Apoptosis in sea urchin oocytes, eggs, and early embryos publication-title: Mol. Reprod. Dev. – volume: 70 start-page: 91 year: 2005 end-page: 102 article-title: Germinal vesicle breakdown is not fully dependent on MAPK activation in maturing oocytes of marine nemertean worms publication-title: Mol. Reprod. Dev. – volume: 23 start-page: 90 year: 2015 end-page: 100 article-title: Programmed cell death in aging publication-title: Ageing Res. Rev. – volume: 130 start-page: 2867 year: 2003 end-page: 2879 article-title: Endoplasmic reticulum reorganizations and Ca signaling in maturing and fertilized oocytes of marine protostome worms: the roles of MAPKs and MPF publication-title: Development – volume: 40 start-page: 293 year: 2010 end-page: 302 article-title: Lysosomal rupture, necroapoptotic interactions and potential crosstalk between cysteine proteases in neurons shortly after focal ischemia publication-title: Neurobiol. Dis. – volume: 45 start-page: e398 year: 2010 end-page: e404 article-title: ageing of porcine oocytes: changes in phosphorylation of the mitogen‐activated protein kinase (MAPK) and parthenogenetic activability publication-title: Reprod. Domest. Anim. – volume: 126 start-page: 1011 year: 1999 end-page: 1022 article-title: Genetic control of programmed cell death in hermaphrodite germline publication-title: Development – volume: 237 start-page: 29 year: 2001 end-page: 44 article-title: Postmeiotic unfertilized starfish eggs die by apoptosis publication-title: Dev. Biol. – volume: 73 start-page: 1578 year: 2006 end-page: 1590 article-title: Differing mechanisms of cAMP‐ versus seawater‐induced oocyte maturation in marine nemertean worms I. The roles of serine/threonine kinases and phosphatases publication-title: Mol. Reprod. Dev. – volume: 182 start-page: 41 year: 2000 end-page: 49 article-title: Aponecrosis: morphological and biochemical exploration of a syncretic process of cell death sharing apoptosis and necrosis publication-title: J. Cell. Physiol. – volume: 176 start-page: 243 year: 1996 end-page: 363 article-title: Repetitive calcium waves induced by fertilization in the nemertean worm publication-title: Dev. Biol. – volume: 105 start-page: 325 year: 1995 end-page: 330 article-title: Decrease of histone H1 kinase activity in relation to parthenogenetic activation of pig follicular oocytes matured and aged publication-title: J. Reprod. Fertil. – volume: 10 start-page: 381 year: 2008 end-page: 390 article-title: Caffeine treatment prevents age‐related changes in ovine oocytes and increases cell numbers in blastocysts produced by somatic cell nuclear transfer publication-title: Cloning Stem Cells – volume: 17 start-page: 35 year: 2000 end-page: 41 article-title: Effect of oocyte aging on parthenogenetic activation with cycloheximide and alteration of the activity of maturation promoting factor during aging in bovine oocytes publication-title: J. Mamm. Ova. Res. – volume: 303 start-page: 336 year: 2007 end-page: 346 article-title: Apoptosis in early development of the sea urchin, publication-title: Dev. Biol. – volume: 22 start-page: 58 year: 2015 end-page: 73 article-title: Essential accessory aspects of cell death: recommendations of the NCCD 2015 publication-title: Cell Death Differ. – volume: 12 start-page: 1490 year: 2005 end-page: 1496 article-title: Redundant cell death mechanisms as relics and backups publication-title: Cell Death Differ. – volume: 138 start-page: 223 year: 2009 end-page: 234 article-title: Pyruvate prevents aging of mouse oocytes publication-title: Reproduction – volume: 74 start-page: 395 year: 2006 end-page: 402 article-title: Age‐associated changes in mouse oocytes during postovulatory culture: possible role of meiotic kinases and survival factor BCL2 publication-title: Biol. Reprod. – volume: 124 start-page: 745 year: 2002 end-page: 754 article-title: Mechanisms underlying oocyte activation and postovulatory ageing publication-title: Reproduction – volume: 56 start-page: 253 year: 1997 end-page: 259 article-title: Dynamics of maturation‐promoting factor and its constituent proteins during maturation of bovine oocytes publication-title: Biol. Reprod. – volume: 517 start-page: 311 year: 2015 end-page: 320 article-title: Necroptosis and its role in inflammation publication-title: Nature – volume: 287 start-page: 243 year: 2000 end-page: 261 article-title: Multiple triggers of oocyte maturation in nemertean worms: the roles of calcium and serotonin publication-title: J. Exp. Zool. – volume: 351 start-page: 95 year: 2000 end-page: 105 article-title: Specificity and mechanism of action of some commonly used protein kinase inhibitors publication-title: Biochem. J. – volume: 202 start-page: 1 year: 1998 end-page: 13 article-title: MAP kinase inactivation is required only for G2‐M phase transition in early embryogenesis cell cycles of the starfishes and publication-title: Dev. Biol. – volume: 23 start-page: 567 year: 2013 end-page: 574 article-title: Diversity of cell death pathways: insight from the fly ovary. (2013) publication-title: Trends Cell Biol. – volume: 450 start-page: 1182 year: 2014 end-page: 1187 article-title: Calcium signaling and endoplasmic reticulum dynamics during fertilization in marine protostome worms belonging to the phylum Nemertea publication-title: Biochem. Biophys. Res. Commun. – volume: 15 start-page: 1139 year: 2008 end-page: 1146 article-title: Living with death: the evolution of the mitochondrial pathway of apoptosis in animals publication-title: Cell Death Differ. – volume: 62 start-page: 132 year: 2002 end-page: 138 article-title: Association of MPF, MAPK, and nuclear progression dynamics during activation of young and aged bovine oocytes publication-title: Mol. Reprod. Dev. – volume: 63 start-page: 715 year: 2000 end-page: 722 article-title: Maturation/M‐Phase promoting factor: a regulator of aging in porcine oocytes publication-title: Biol. Reprod. – volume: 30 start-page: 105 year: 2003 end-page: 116 article-title: CI‐1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK) publication-title: Semin. Oncol. – volume: 49 start-page: 460 year: 2011 end-page: 471 article-title: Offspring from intracytoplasmic sperm injection of aged mouse oocytes treated with caffeine or MG132 publication-title: Genesis – volume: 300 start-page: 321 year: 2006 end-page: 334 article-title: The genomic underpinnings of apoptosis in publication-title: Dev. Biol. – volume: 224 start-page: 137 year: 2013 end-page: 155 article-title: Oocyte maturation and fertilization in marine nemertean worms: using similar sorts of signaling pathways as in mammals, but often with differing results publication-title: Biol. Bull. – volume: 1833 start-page: 3499 year: 2013 end-page: 3506 article-title: Developmentally programmed cell death in publication-title: Biochim. Biophys. Acta – volume: 77 start-page: 497 year: 2010 end-page: 510 article-title: Stimulators of AMP‐activated kinase inhibit seawater‐ but not cAMP‐induced oocyte maturation in a marine worm: implications for interactions between cAMP and AMPK signaling publication-title: Mol. Reprod. Dev. – volume: 19 start-page: 107 year: 2012 end-page: 120 article-title: Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 publication-title: Cell Death Differ. – volume: 276 start-page: G1 year: 1999 end-page: G6 article-title: V. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis publication-title: Am. J. Physiol. – volume: 277 start-page: 2 year: 2010 end-page: 21 article-title: ERK and cell death: mechanisms of ERK‐induced cell death – apoptosis, autophagy and senescence publication-title: FEBS J. – volume: 81 start-page: 928 year: 2014 end-page: 945 article-title: Post‐ovulatory aging of oocytes disrupts kinase signaling pathways and lysosome biogenesis publication-title: Mol. Reprod. Dev. – volume: 37 start-page: 767 year: 2015 end-page: 776 article-title: Evolutionary analyses of caspase‐8 and its paralogs: deep origins of the apoptotic signaling pathways publication-title: BioEssays – volume: 8 start-page: e23672 year: 2011 article-title: Unfertilized eggs die by Bad‐dependent apoptosis under the control of Cdk1 and JNK publication-title: PLoS One – volume: 8 start-page: R226 year: 2007 article-title: Surprising complexity of the ancestral apoptosis network publication-title: Genome Biol. – volume: 76 start-page: 708 year: 2009 end-page: 721 article-title: Interactions between mitogen‐activated protein kinase and protein kinase C signaling during oocyte maturation and fertilization in a marine worm publication-title: Mol. Reprod. Dev. – volume: 67 start-page: 366 year: 2004 end-page: 383 article-title: MAP kinases regulate unfertilized egg apoptosis and fertilization suppresses death via Ca signaling publication-title: Mol. Reprod. Dev. – volume: 11 start-page: 700 year: 2010 end-page: 714 article-title: Molecular mechanisms of necroptosis: an ordered cellular explosion publication-title: Nat. Rev. Mol. Cell. Biol. – volume: 22 start-page: 882 year: 2010 end-page: 888 article-title: Genetic control of necrosis – another type of programmed cell death publication-title: Curr. Opin. Cell Biol. – volume: 1833 start-page: 3448 year: 2013 end-page: 3459 article-title: Crosstalk between apoptosis, necrosis and autophagy publication-title: Biochim. Biophys. Acta – volume: 48 start-page: 185 year: 1961 end-page: 203 article-title: Fertilizable life of golden hamster ova and their morphological changes at the time of losing fertilizability publication-title: J. Exp. Zool. – start-page: 237 year: 2014 end-page: 247 – volume: 15 start-page: 573 year: 2009 end-page: 585 article-title: Oocyte aging: cellular and molecular changes, developmental potential and reversal possibility publication-title: Hum. Reprod. Update – volume: 20 start-page: 1019 year: 2015 end-page: 1025 article-title: Apoptosis in mammalian oocytes: a review publication-title: Apoptosis – volume: 19 start-page: 436 year: 2014 end-page: 450 article-title: Different routes lead to apoptosis in unfertilized sea urchin eggs publication-title: Apoptosis – volume: 15 start-page: 1387 year: 2004 end-page: 1396 article-title: Induction of apoptosis in starfish eggs requires spontaneous inactivation of MAPK (extracellular signal‐regulated kinase) followed by activation of p38 MAPK publication-title: Mol. Biol. Cell – volume: 9 start-page: 1527 year: 2013 end-page: 1539 article-title: Autophagy is used as a survival program in unfertilized sea urchin eggs that are destined to die by apoptosis after inactivation of MAPK1/3 (ERK2/1) publication-title: Autophagy – volume: 14 start-page: 11 year: 2013 article-title: Unlaid eggs degrade by apoptosis in the genital tract publication-title: BMC Cell Biol. – volume: 579 start-page: 236 year: 2005 end-page: 240 article-title: PD98059 and U0126 activate AMP‐activated protein kinase by increasing cellular AMP:ATP ratio and not via inhibition of the MAP kinase pathway publication-title: FEBS Lett. – start-page: 129 year: 1987 end-page: 137 – ident: e_1_2_6_32_1 doi: 10.1038/nature14191 – ident: e_1_2_6_33_1 doi: 10.1262/jrd.20061 – ident: e_1_2_6_39_1 doi: 10.1006/dbio.2001.0337 – ident: e_1_2_6_49_1 doi: 10.1242/dev.00508 – ident: e_1_2_6_4_1 doi: 10.1042/bj3510095 – ident: e_1_2_6_7_1 doi: 10.1371/journal.pone.0023672 – ident: e_1_2_6_19_1 doi: 10.1016/j.tcb.2013.07.005 – ident: e_1_2_6_21_1 doi: 10.1095/biolreprod63.3.715 – ident: e_1_2_6_55_1 doi: 10.1002/mrd.10072 – ident: e_1_2_6_57_1 doi: 10.1016/j.arr.2015.04.002 – ident: e_1_2_6_8_1 doi: 10.1111/j.1439-0531.2010.01588.x – ident: e_1_2_6_35_1 doi: 10.1016/j.ydbio.2006.08.053 – ident: e_1_2_6_60_1 doi: 10.1095/biolreprod56.1.253 – ident: e_1_2_6_56_1 doi: 10.1007/s10495-015-1136-y – ident: e_1_2_6_54_1 doi: 10.1016/j.ydbio.2006.11.018 – volume: 276 start-page: G1 year: 1999 ident: e_1_2_6_24_1 article-title: V. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis publication-title: Am. J. Physiol. – ident: e_1_2_6_53_1 doi: 10.1095/biolreprod.105.046169 – ident: e_1_2_6_26_1 doi: 10.1016/j.ceb.2010.09.002 – ident: e_1_2_6_25_1 doi: 10.1530/REP-09-0122 – ident: e_1_2_6_58_1 doi: 10.1038/nrm2970 – ident: e_1_2_6_3_1 doi: 10.1111/j.1742-4658.2009.07366.x – ident: e_1_2_6_48_1 doi: 10.1002/1097-010X(20000801)287:3<243::AID-JEZ6>3.0.CO;2-B – ident: e_1_2_6_45_1 doi: 10.1002/mrd.21032 – ident: e_1_2_6_27_1 doi: 10.1002/mrd.22413 – ident: e_1_2_6_20_1 doi: 10.1530/jrf.0.1050325 – ident: e_1_2_6_50_1 doi: 10.1002/mrd.20597 – ident: e_1_2_6_17_1 doi: 10.4161/auto.25712 – ident: e_1_2_6_51_1 doi: 10.1002/mrd.21177 – ident: e_1_2_6_40_1 doi: 10.1091/mbc.E03-06-0367 – ident: e_1_2_6_46_1 doi: 10.1530/REP-10-0509 – ident: e_1_2_6_41_1 doi: 10.1274/jmor.17.35 – volume: 206 start-page: 3487 year: 2003 ident: e_1_2_6_36_1 article-title: A marine diatom‐derived aldehyde induces apoptosis in copepod and sea urchin embryos publication-title: J. Exp. Biol. doi: 10.1242/jeb.00580 – ident: e_1_2_6_38_1 doi: 10.1002/bies.201500010 – ident: e_1_2_6_6_1 doi: 10.1016/j.febslet.2004.11.084 – ident: e_1_2_6_12_1 doi: 10.1002/(SICI)1097-4652(200001)182:1<41::AID-JCP5>3.0.CO;2-7 – ident: e_1_2_6_63_1 doi: 10.1186/gb-2007-8-10-r226 – ident: e_1_2_6_30_1 doi: 10.1038/cdd.2008.65 – ident: e_1_2_6_37_1 doi: 10.1002/mrd.20023 – ident: e_1_2_6_59_1 doi: 10.1002/mrd.1120 – volume: 126 start-page: 1011 year: 1999 ident: e_1_2_6_16_1 article-title: Genetic control of programmed cell death in Caenorhabditis elegans hermaphrodite germline publication-title: Development doi: 10.1242/dev.126.5.1011 – ident: e_1_2_6_47_1 doi: 10.1016/j.bbrc.2014.03.156 – ident: e_1_2_6_10_1 doi: 10.1006/dbio.1998.8981 – ident: e_1_2_6_34_1 doi: 10.1007/s10495-013-0950-3 – ident: e_1_2_6_28_1 doi: 10.1093/humupd/dmp014 – ident: e_1_2_6_29_1 doi: 10.1016/j.bbamcr.2013.06.001 – ident: e_1_2_6_42_1 doi: 10.1002/mrd.20188 – ident: e_1_2_6_5_1 doi: 10.1016/j.bbamcr.2013.06.014 – ident: e_1_2_6_61_1 doi: 10.1002/jez.1401480303 – start-page: 129 volume-title: Reproduction and Development of Marine Invertebrates of the Northern Pacific Coast year: 1987 ident: e_1_2_6_43_1 – ident: e_1_2_6_14_1 doi: 10.1038/cdd.2014.137 – ident: e_1_2_6_62_1 doi: 10.1006/dbio.2001.0361 – ident: e_1_2_6_18_1 doi: 10.1186/1471-2121-14-11 – ident: e_1_2_6_11_1 doi: 10.1530/rep.0.1240745 – ident: e_1_2_6_44_1 doi: 10.1006/dbio.1996.0131 – ident: e_1_2_6_23_1 doi: 10.1089/clo.2007.0091 – ident: e_1_2_6_31_1 doi: 10.1002/dvg.20756 – ident: e_1_2_6_15_1 doi: 10.1038/sj.cdd.4401607 – ident: e_1_2_6_22_1 doi: 10.1016/j.nbd.2010.06.003 – ident: e_1_2_6_52_1 doi: 10.1086/BBLv224n3p137 – ident: e_1_2_6_9_1 doi: 10.1007/978-1-62703-974-1_16 – ident: e_1_2_6_2_1 doi: 10.1053/j.seminoncol.2003.08.012 – ident: e_1_2_6_13_1 doi: 10.1038/cdd.2011.96
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Snippet	The roles of maturation‐promoting factor (MPF) and an extracellular signal regulated kinase form of mitogen‐activated protein kinase (ERK MAPK) are analyzed... The roles of maturation‐promoting factor ( MPF ) and an extracellular signal regulated kinase form of mitogen‐activated protein kinase ( ERK MAPK ) are... The roles of maturation-promoting factor (MPF) and an extracellular signal regulated kinase form of mitogen-activated protein kinase (ERK MAPK) are analyzed...
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SubjectTerms	Animals apoptosis Apoptosis - physiology Butadienes - pharmacology Cells, Cultured Cellular Senescence - drug effects Cellular Senescence - physiology Cerebratulus Colforsin - pharmacology Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - metabolism Female Immunoblotting Invertebrates - cytology Invertebrates - drug effects Invertebrates - metabolism Kinases Maturation-Promoting Factor - antagonists & inhibitors Maturation-Promoting Factor - metabolism necroptosis nemertean Nitriles - pharmacology non‐apoptotic regulated cell death Oocytes - cytology Oocytes - drug effects Oocytes - physiology Protein Kinase Inhibitors - pharmacology Purines - pharmacology Seawater - parasitology Time Factors Vasodilator Agents
Title	Oocyte aging in a marine protostome worm: The roles of maturation‐promoting factor and extracellular signal regulated kinase form of mitogen‐activated protein kinase
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