Design of a targeted next‐generation DNA sequencing panel for pediatric T‐cell lymphoblastic lymphoma to unravel biology and optimize treatment

Low incidence and molecular heterogeneity of pediatric T‐cell lymphoblastic lymphoma (T‐LBL) require an international, large‐scale effort to identify novel clinical biomarkers. The ongoing international clinical trial LBL2018 (NCT04043494) represents an ideal opportunity to implement a common analyt...

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Veröffentlicht in:	Genes chromosomes & cancer Jg. 61; H. 8; S. 459 - 470
Hauptverfasser:	Ruether, Charlotte, Wuensch, Christian, Randau, Gerrit, Michgehl, Ulf, Trautmann, Marcel, Hartmann, Wolfgang, Sandmann, Sarah, Dugas, Martin, Khanam, Tasneem, Burkhardt, Birgit
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Hoboken, USA John Wiley & Sons, Inc 01.08.2022 Wiley Subscription Services, Inc
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Biology Cell cycle Child clinical trials Deoxyribonucleic acid DNA DNA repair DNA sequencing Epigenesis, Genetic Epigenetics Gene regulation Genes High-Throughput Nucleotide Sequencing Humans lymphoblastic lymphoma Lymphoma Lymphoma, T-Cell - genetics Mutation Neoplasm Recurrence, Local - genetics pediatric oncology Pediatrics Phosphatidylinositol 3-Kinases - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics Proto-Oncogene Proteins c-akt - genetics Sequence Analysis, DNA T-Lymphocytes targeted gene panel variant classification variant classification clinical trials targeted gene panel pediatric oncology lymphoblastic lymphoma
ISSN:	1045-2257, 1098-2264, 1098-2264
Online-Zugang:	Volltext
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