Cross‐sectional and Mendelian randomization study of fibroblast growth factor 19 reveals causal associations with metabolic diseases

Background and Aim Fibroblast growth factor 19 (FGF19) is an intestinal‐derived factor that plays a role in metabolic diseases. We performed a differential study of circulating FGF19 levels and investigated the causal effects of FGF19 on metabolic diseases using Mendelian randomization (MR). Methods...

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Bibliographic Details
Published in:	Journal of gastroenterology and hepatology Vol. 39; no. 12; pp. 2872 - 2879
Main Authors:	Li, Yan, Dai, Changyong, Yang, Haiqing, Zeng, Huang, Ruan, Yuhua, Dai, Mingjia, Hao, Jungui, Wang, Liping, Yan, Xuebing, Ji, Fang
Format:	Journal Article
Language:	English
Published:	Australia Wiley Subscription Services, Inc 01.12.2024
Subjects:	Adult Aspartate aminotransferase Biomarkers Biomarkers - blood Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - genetics Cholesterol Cirrhosis Cross-Sectional Studies Diabetes Diabetes mellitus (non-insulin dependent) Fatty liver Female fibroblast growth factor 19 Fibroblast Growth Factors - blood Fibroblast Growth Factors - genetics Fibroblasts Genome-wide association studies Genome-Wide Association Study Genomic analysis Growth factors Humans Lipids Liver cirrhosis Liver diseases Male Mendelian randomization Mendelian Randomization Analysis metabolic diseases Metabolic Diseases - epidemiology Metabolic Diseases - genetics Metabolic disorders Middle Aged Non-alcoholic Fatty Liver Disease - blood Non-alcoholic Fatty Liver Disease - genetics nonalcoholic fatty liver disease Obesity - genetics Population studies Statistical analysis Triglycerides nonalcoholic fatty liver disease Mendelian randomization metabolic diseases fibroblast growth factor 19
ISSN:	0815-9319, 1440-1746, 1440-1746
Online Access:	Get full text
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