A face‐to‐face comparison of the BBB cell models hCMEC/D3 and hBMEC for their applicability to adenoviral expression of transporters

The blood–brain barrier (BBB) is a structure mainly formed by brain capillary endothelial cells (BCEC) whose role is to regulate the exchange of compounds between the blood and the brain. In this process efflux and uptake transporters play a key role. Aim of this study was to compare the two previou...

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Bibliographic Details
Published in:	Journal of neurochemistry Vol. 168; no. 9; pp. 2611 - 2620
Main Authors:	Taggi, Valerio, Schäfer, Anima M., Dolce, Asaél, Meyer zu Schwabedissen, Henriette E.
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01.09.2024
Subjects:	adenoviral expression system Adenoviridae - genetics Blood-brain barrier Blood-Brain Barrier - metabolism Capacitance Cell culture Cell Line Cell lines drug transporters Efflux Electrical junctions Electrical resistivity Endothelial cells Endothelial Cells - metabolism Gene expression hBMEC hCMEC/D3 Humans Membrane permeability Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism mRNA Permeability Permeability coefficient Protein transport Proteins Tight junctions Transferrin Von Willebrand factor drug transporters hBMEC hCMEC/D3 blood–brain barrier adenoviral expression system
ISSN:	0022-3042, 1471-4159, 1471-4159
Online Access:	Get full text
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