Inflammation alters the expression pattern of drug transporters during Caco‐2 cell stimulation and azoxymethane‐induced colon tumorigenesis

Drug transporters play a pivotal role in modulating drug disposition and are subject to alterations under inflammatory conditions. This study aimed to elucidate the intricate expression patterns of drug transporters during both acute and chronic inflammation, which are closely linked to malignant tr...

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Bibliographic Details
Published in:	Journal of biochemical and molecular toxicology Vol. 38; no. 9; pp. e23815 - n/a
Main Authors:	El‐Daly, Sherien M., Gouhar, Shaimaa A., Abdelrahman, Sahar S.
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.09.2024
Subjects:	ABCB1 ABCC2 ABCG2 Animals ATP Binding Cassette Transporter, Subfamily B - genetics ATP Binding Cassette Transporter, Subfamily B - metabolism ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism Azoxymethane Azoxymethane - toxicity Caco-2 Cells Carcinogenesis - chemically induced Carcinogenesis - metabolism Cell Transformation, Neoplastic - chemically induced Cell Transformation, Neoplastic - metabolism Colitis Colon Colonic Neoplasms - chemically induced Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal cancer drug transporters Humans Immunohistochemistry Inflammation Inflammation - chemically induced Inflammation - metabolism Inflammation - pathology Interleukin 6 Interleukin-6 - metabolism Male Mice Multidrug Resistance-Associated Protein 2 Multidrug Resistance-Associated Proteins - metabolism Neoplasm Proteins - biosynthesis Neoplasm Proteins - metabolism Tumorigenesis drug transporters ABCB1 ABCC2 colitis inflammation ABCG2
ISSN:	1095-6670, 1099-0461, 1099-0461
Online Access:	Get full text
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