Tannerella forsythia‐produced methylglyoxal causes accumulation of advanced glycation endproducts to trigger cytokine secretion in human monocytes

The periodontal pathogen Tannerella forsythia has the unique ability to produce methylglyoxal (MGO), an electrophilic compound which can covalently modify amino acid side chains and generate inflammatory adducts known as advanced glycation endproducts (AGEs). In periodontitis, concentrations of MGO...

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Bibliographic Details
Published in:	Molecular oral microbiology Vol. 33; no. 4; pp. 292 - 299
Main Authors:	Settem, R.P., Honma, K., Shankar, M., Li, M., LaMonte, M., Xu, D., Genco, R.J., Browne, R.W., Sharma, A.
Format:	Journal Article
Language:	English
Published:	Denmark Wiley Subscription Services, Inc 01.08.2018
Subjects:	Adducts Advanced glycosylation end products AGEs Amino acids Biocompatibility Biomedical materials Chain mobility Chains Collagen Cytokines Cytokines - metabolism Electrophoresis Electrophoretic mobility Glycation End Products, Advanced - metabolism Glycosylation Gum disease Homology Humans Inflammation Inflammation - microbiology methylglyoxal Methylglyoxal synthase Monocytes Monocytes - metabolism Periodontitis Periodontitis - microbiology Proteins Pyruvaldehyde Pyruvaldehyde - metabolism RAGE Tannerella forsythia Tannerella forsythia - pathogenicity THP-1 Cells Virulence Virulence Factors Tannerella forsythia methylglyoxal AGEs RAGE periodontitis
ISSN:	2041-1006, 2041-1014, 2041-1014
Online Access:	Get full text
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