Heroin‐induced respiratory depression and the influence of dose variation: within‐subject between‐session changes following dose reduction

Background and aims Globally, more than 100 000 people die annually from opioid overdose. Opportunities to study physiological events in at‐risk individuals are limited. This study examined variation of opioid dose and impact on respiratory depression in a chronic injecting heroin user at separate t...

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Bibliographic Details
Published in:	Addiction (Abingdon, England) Vol. 115; no. 10; pp. 1954 - 1959
Main Authors:	Tas, Basak, Jolley, Caroline J., Kalk, Nicola J., Waal, Rob, Bell, James, Strang, John
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01.10.2020
Subjects:	Addictions Analgesics, Opioid - pharmacology Anatomical systems Apnea Carbon dioxide Clinical research Depression Dosage Dose-Response Relationship, Drug Drug addiction Drug overdose Drug Tapering HAT Heroin Heroin - pharmacology Heroin Dependence - drug therapy Heroin Dependence - physiopathology Humans Hypoventilation Male Mental depression Middle Aged Narcotics opioid Opioids Overdose Oxygen Pauses Physiology Respiration respiratory Respiratory Insufficiency - chemically induced Saturation overdose Depression HAT heroin respiratory opioid
ISSN:	0965-2140, 1360-0443, 1360-0443
Online Access:	Get full text
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