Effect of recombinant ADAMTS‐13 on microthrombosis and brain injury after experimental subarachnoid hemorrhage

Summary Background A common complication after aneurysmal subarachnoid hemorrhage (SAH) is delayed cerebral ischemia (DCI), which is associated with vasospasm and other mechanisms such as microthrombosis. ADAMTS‐13 activity plays a role in the prevention of thrombus formation in the cerebral microva...

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Bibliographic Details
Published in:	Journal of thrombosis and haemostasis Vol. 12; no. 6; pp. 943 - 947
Main Authors:	Vergouwen, M. D. I., Knaup, V. L., Roelofs, J. J. T. H., Boer, O. J., Meijers, J. C. M.
Format:	Journal Article
Language:	English
Published:	England Elsevier Limited 01.06.2014
Subjects:	ADAM Proteins - pharmacology ADAMTS13 Protein ADAMTS13 protein, human Animals Brain - drug effects Brain - pathology Brain Injuries - diagnosis Brain Injuries - etiology Brain Injuries - prevention & control Brain Ischemia - diagnosis Brain Ischemia - etiology Brain Ischemia - prevention & control Cytoprotection Disease Models, Animal hemostasis Humans Intracranial Thrombosis - diagnosis Intracranial Thrombosis - etiology Intracranial Thrombosis - prevention & control Metalloendopeptidases - deficiency Metalloendopeptidases - genetics Mice, Inbred C57BL Mice, Knockout Neuroprotective Agents - pharmacology Recombinant Proteins - pharmacology subarachnoid hemorrhage Subarachnoid Hemorrhage - complications thrombosis Time Factors von Willebrand factor thrombosis hemostasis subarachnoid hemorrhage von Willebrand factor ADAMTS13 protein, human
ISSN:	1538-7933, 1538-7836, 1538-7836
Online Access:	Get full text
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