Prevalence, incidence, and severity of hand eczema in the general population – A systematic review and meta‐analysis

Accurate assessments of the burden of hand eczema (HE) in the general population are important for public awareness and intervention. The aim of this systematic review and meta‐analysis was to provide updated estimates of prevalence and incidence, alongside additional epidemiological endpoints on HE...

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Vydáno v:Contact dermatitis Ročník 84; číslo 6; s. 361 - 374
Hlavní autoři: Quaade, Anna S., Simonsen, Anne B., Halling, Anne‐Sofie, Thyssen, Jacob P., Johansen, Jeanne D.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Oxford, UK Blackwell Publishing Ltd 01.06.2021
Wiley Subscription Services, Inc
Témata:
Atopic dermatitis
Chronic illnesses
Dermatitis
Eczema
Epidemiology
general population
hand eczema
incidence
Meta-analysis
Population
prevalence
severity
Sex differences
Systematic review
unselected
severity
epidemiology
prevalence
hand eczema
unselected
general population
incidence
ISSN:0105-1873, 1600-0536, 1600-0536
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Shrnutí:Accurate assessments of the burden of hand eczema (HE) in the general population are important for public awareness and intervention. The aim of this systematic review and meta‐analysis was to provide updated estimates of prevalence and incidence, alongside additional epidemiological endpoints on HE in the general population. PubMed, Embase and Web of Science were searched for studies reporting the prevalence and/or incidence of HE in the general population. Proportion meta‐analyses were performed to calculate pooled estimates of prevalence, incidence, severity, and the proportion of individuals with HE and a history of atopic dermatitis. Sixty‐six studies were included in the quantitative analysis encompassing 568 100 individuals. The pooled estimates for lifetime, 1‐year, and point prevalence were 14.5% (95% confidence interval [CI]: 12.6–16.5), 9.1% (95% CI: 8.4–9.8) and 4.0% (95% CI: 2.6–5.7), respectively. The pooled incidence rate of HE was 7.3 cases/1000 person‐years (95% CI: 5.4–9.5). The occurrence of HE was 1.5–2 times higher in females than males. More than one third suffered from moderate/severe disease and around one third had a history of atopic dermatitis. HE was a recurrent, long‐lasting disease with an average age at onset of the early‐ to mid‐twenties. In conclusion; HE is a highly prevalent disease in the general population and carries a significant risk of long‐term or chronic disease.
Bibliografie:Funding information
LEO Fondet, Grant/Award Number: 114; Lundbeckfonden
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ISSN:0105-1873
1600-0536
1600-0536
DOI:10.1111/cod.13804