Impaired bone and muscle development in young people treated with antiepileptic drugs

Summary Objective Antiepileptic drugs (AEDs) are associated with reduced bone density, balance impairment, and increased fracture risk in adults. However, pediatric data are limited. Therefore, we aimed to examine bone, muscle, and balance outcomes in young patients taking AEDs. Methods We undertook...

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Bibliographic Details
Published in:	Epilepsia (Copenhagen) Vol. 58; no. 11; pp. 1931 - 1938
Main Authors:	Simm, Peter J., Seah, Sebastian, Gorelik, Alex, Gilbert, Lauren, Nuguid, Jenning, Werther, George A., Mackay, Mark T., Freeman, Jeremy L., Petty, Sandra J., Wark, John D.
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.11.2017
Subjects:	Adolescent Anticonvulsants - administration & dosage Anticonvulsants - adverse effects Antiepileptic agents Australia - epidemiology Balance Body weight Bone density Bone Density - drug effects Bone Density - physiology Bone mineral density Cancellous bone Case-Control Studies Child Child, Preschool Computed tomography Diseases in Twins - chemically induced Diseases in Twins - diagnostic imaging Diseases in Twins - epidemiology Drug development Dual energy X-ray absorptiometry Epilepsy Epilepsy - diagnostic imaging Epilepsy - drug therapy Epilepsy - epidemiology Female Fractures Fractures, Bone - chemically induced Fractures, Bone - diagnostic imaging Fractures, Bone - epidemiology Humans Male Muscle Development - drug effects Muscle Development - physiology Registries Siblings Tibia Treatment Outcome Epilepsy Bone density Fractures
ISSN:	0013-9580, 1528-1167, 1528-1167
Online Access:	Get full text
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