Multimodal Ultrasound Imaging in the Diagnosis of Primary Giant Cell Tumor of the Breast: A Case Report and Literature Review

ABSTRACT Giant cell tumor of soft tissue (GCT‐ST) is an extremely rare phenomenon in the breast. Herein, a case involving a 75‐year‐old female with a painless lump and bloody discharge from the nipple of her left breast is reported. A diagnosis of malignant tumor was arrived at by observing the loca...

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Bibliographic Details
Published in:Journal of clinical ultrasound Vol. 53; no. 4; pp. 885 - 892
Main Authors: Chen, Fei, Chen, Yu‐Jia, Hu, Yan‐Ze
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01.05.2025
Wiley Subscription Services, Inc
Subjects:
Aged
Biopsy
Breast
Breast - diagnostic imaging
Breast - surgery
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - pathology
Breast Neoplasms - surgery
breast tumor
Diagnosis
Diagnosis, Differential
Female
giant cell tumor of soft tissue
Giant Cell Tumors - diagnostic imaging
Giant Cell Tumors - pathology
Giant Cell Tumors - surgery
Humans
Immunohistochemistry
Literature reviews
Lymph nodes
Malignancy
Medical imaging
Microvasculature
Multimodal Imaging - methods
pathology
Soft tissues
Tumors
Ultrasonic imaging
ultrasonography
Ultrasonography, Mammary - methods
Ultrasound
diagnosis
giant cell tumor of soft tissue
breast tumor
pathology
ultrasonography
ISSN:0091-2751, 1097-0096, 1097-0096
Online Access:Get full text
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Summary:ABSTRACT Giant cell tumor of soft tissue (GCT‐ST) is an extremely rare phenomenon in the breast. Herein, a case involving a 75‐year‐old female with a painless lump and bloody discharge from the nipple of her left breast is reported. A diagnosis of malignant tumor was arrived at by observing the location of the tumor, interior echo, margins, vascular distribution, hardness, and microvascular density on preoperative multimodal ultrasonography. However, no evidence of malignancy was found on ultrasonography‐guided nuclear needle biopsy or rapid intraoperative pathological examination. Subsequently, an excisional biopsy was performed, and GCT‐ST coincident with high‐grade ductal carcinoma in situ were confirmed using histopathology and immunohistochemistry. Accordingly, the patient underwent left‐sided mastectomy and sentinel lymph node biopsy. This case emphasizes the complexity of the clinical and pathological diagnosis of GCT‐ST in the breast and may raise the awareness of clinicians and sonographers to the advantages of multimodal ultrasound imaging in the diagnosis of GCT‐ST in the breast. Pathologists should consider the possibility of GCT‐ST when encountering a giant cell‐rich mass in the breast.
Bibliography:Funding
This work was supported by Zhejiang Provincial Medical Scientific Research Foundation of China under Grant No. 2024KY1675.
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ISSN:0091-2751
1097-0096
1097-0096
DOI:10.1002/jcu.23902