Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention

Identification of cost-effective interventions to maintain muscle mass, muscle strength, and physical performance during muscle wasting and aging is an important public health challenge. It requires understanding of the cellular and molecular mechanisms involved. Muscle-deconditioning processes have...

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Veröffentlicht in:Molecular aspects of medicine Jg. 50; H. 50; S. 56 - 87
Hauptverfasser: Brioche, Thomas, Pagano, Allan F., Py, Guillaume, Chopard, Angèle
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Ltd 01.08.2016
Elsevier
Schlagworte:
Adipose Tissue - metabolism
Adipose Tissue - pathology
Aging - drug effects
Aging - physiology
Animals
Apoptosis
Beta-hydroxy-beta-methylbutyrate (HMB)
Dietary Supplements
Exercise
Glucosephosphate Dehydrogenase - metabolism
Hormone Replacement Therapy
Human health and pathology
Humans
Intermuscular adipose tissue (IMAT)
Life Sciences
Microgravity
Mitochondria - metabolism
Models, Animal
Models, Theoretical
Muscle disuse
Muscle, Skeletal - pathology
Muscle, Skeletal - physiopathology
Sarcopenia
Sarcopenia - pathology
Sarcopenia - physiopathology
Sarcopenia - prevention & control
Signal Transduction - drug effects
Tissues and Organs
Valerates - administration & dosage
Weightlessness
Intermuscular adipose tissue (IMAT)
Sarcopenia
Muscle disuse
Exercise
Beta-hydroxy-beta-methylbutyrate (HMB)
Microgravity
beta-hydroxy-beta-methylbutyrate (hmb)
microgravity
microgravité
muscle disuse
muscle
exercise
tissu adipeux intermusculaire
intermuscular adipose tissue (imat)
sarcopenie
sarcopenia
ISSN:0098-2997, 1872-9452
Online-Zugang:Volltext
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Abstract Identification of cost-effective interventions to maintain muscle mass, muscle strength, and physical performance during muscle wasting and aging is an important public health challenge. It requires understanding of the cellular and molecular mechanisms involved. Muscle-deconditioning processes have been deciphered by means of several experimental models, bringing together the opportunities to devise comprehensive analysis of muscle wasting. Studies have increasingly recognized the importance of fatty infiltrations or intermuscular adipose tissue for the age-mediated loss of skeletal-muscle function and emphasized that this new important factor is closely linked to inactivity. The present review aims to address three main points. We first mainly focus on available experimental models involving cell, animal, or human experiments on muscle wasting. We next point out the role of intermuscular adipose tissue in muscle wasting and aging and try to highlight new findings concerning aging and muscle-resident mesenchymal stem cells called fibro/adipogenic progenitors by linking some cellular players implicated in both FAP fate modulation and advancing age. In the last part, we review the main data on the efficiency and molecular and cellular mechanisms by which exercise, replacement hormone therapies, and β-hydroxy-β-methylbutyrate prevent muscle wasting and sarcopenia. Finally, we will discuss a potential therapeutic target of sarcopenia: glucose 6-phosphate dehydrogenase.
AbstractList Identification of cost-effective interventions to maintain muscle mass, muscle strength, and physical performance during muscle wasting and aging is an important public health challenge. It requires understanding of the cellular and molecular mechanisms involved. Muscle-deconditioning processes have been deciphered by means of several experimental models, bringing together the opportunities to devise comprehensive analysis of muscle wasting. Studies have increasingly recognized the importance of fatty infiltrations or intermuscular adipose tissue for the age-mediated loss of skeletal-muscle function and emphasized that this new important factor is closely linked to inactivity. The present review aims to address three main points. We first mainly focus on available experimental models involving cell, animal, or human experiments on muscle wasting. We next point out the role of intermuscular adipose tissue in muscle wasting and aging and try to highlight new findings concerning aging and muscle-resident mesenchymal stem cells called fibro/adipogenic progenitors by linking some cellular players implicated in both FAP fate modulation and advancing age. In the last part, we review the main data on the efficiency and molecular and cellular mechanisms by which exercise, replacement hormone therapies, and β-hydroxy-β-methylbutyrate prevent muscle wasting and sarcopenia. Finally, we will discuss a potential therapeutic target of sarcopenia: glucose 6-phosphate dehydrogenase.
Author Py, Guillaume
Brioche, Thomas
Pagano, Allan F.
Chopard, Angèle
Author_xml – sequence: 1
  givenname: Thomas
  surname: Brioche
  fullname: Brioche, Thomas
  email: thomas.brioche@gmail.com
– sequence: 2
  givenname: Allan F.
  surname: Pagano
  fullname: Pagano, Allan F.
– sequence: 3
  givenname: Guillaume
  surname: Py
  fullname: Py, Guillaume
– sequence: 4
  givenname: Angèle
  surname: Chopard
  fullname: Chopard, Angèle
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27106402$$D View this record in MEDLINE/PubMed
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Issue 50
Keywords Intermuscular adipose tissue (IMAT)
Sarcopenia
Muscle disuse
Exercise
Beta-hydroxy-beta-methylbutyrate (HMB)
Microgravity
beta-hydroxy-beta-methylbutyrate (hmb)
microgravity
microgravité
muscle disuse
muscle
exercise
tissu adipeux intermusculaire
intermuscular adipose tissue (imat)
sarcopenie
sarcopenia
Language English
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Snippet Identification of cost-effective interventions to maintain muscle mass, muscle strength, and physical performance during muscle wasting and aging is an...
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SubjectTerms Adipose Tissue - metabolism
Adipose Tissue - pathology
Aging - drug effects
Aging - physiology
Animals
Apoptosis
Beta-hydroxy-beta-methylbutyrate (HMB)
Dietary Supplements
Exercise
Glucosephosphate Dehydrogenase - metabolism
Hormone Replacement Therapy
Human health and pathology
Humans
Intermuscular adipose tissue (IMAT)
Life Sciences
Microgravity
Mitochondria - metabolism
Models, Animal
Models, Theoretical
Muscle disuse
Muscle, Skeletal - pathology
Muscle, Skeletal - physiopathology
Sarcopenia
Sarcopenia - pathology
Sarcopenia - physiopathology
Sarcopenia - prevention & control
Signal Transduction - drug effects
Tissues and Organs
Valerates - administration & dosage
Weightlessness
Title Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention
URI https://dx.doi.org/10.1016/j.mam.2016.04.006
https://www.ncbi.nlm.nih.gov/pubmed/27106402
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