Diagnostic sensitivity and specificity of dark adaptometry for detection of age-related macular degeneration

Difficulty with night vision is a common complaint of patients with age-related macular degeneration (AMD). Consistent with this complaint, dark adaptation (DA) is substantially impaired in these patients. Because of the severity of the deficit, measurement of DA has been suggested as a means for th...

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Veröffentlicht in:Investigative ophthalmology & visual science Jg. 55; H. 3; S. 1427
Hauptverfasser: Jackson, Gregory R, Scott, Ingrid U, Kim, Ivana K, Quillen, David A, Iannaccone, Alessandro, Edwards, John G
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 10.03.2014
Schlagworte:
Aged
Aged, 80 and over
Dark Adaptation - physiology
Diagnosis, Differential
Diagnostic Techniques, Ophthalmological
Female
Humans
Macular Degeneration - diagnosis
Macular Degeneration - physiopathology
Male
Middle Aged
Sensitivity and Specificity
Sensory Thresholds
Visual Acuity
diagnostic
dark adaptation
age-related macular degeneration
human
ISSN:1552-5783, 1552-5783
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Zusammenfassung:Difficulty with night vision is a common complaint of patients with age-related macular degeneration (AMD). Consistent with this complaint, dark adaptation (DA) is substantially impaired in these patients. Because of the severity of the deficit, measurement of DA has been suggested as a means for the diagnosis of AMD. Previous methods for measurement of DA were time intensive (>30 minutes), which made them unsuitable for clinical use. This study evaluated a rapid DA test (≤ 6.5 minutes) for the detection of AMD. Dark adaptation was measured by using the AdaptDx dark adaptometer in two groups: subjects with normal retinal health and subjects with AMD. Subjects were assigned to their group by clinical examination and grading of fundus photographs. Subjects were classified as having DA consistent with normal retinal health (rod intercept ≤ 6.5 minutes) or having dark adaptation consistent with AMD (rod intercept > 6.5 minutes). The eligible sample for analysis included 21 normal adults and 127 AMD patients. The rapid test was found to have a diagnostic sensitivity of 90.6% (P < 0.001) and specificity of 90.5% (P < 0.027). Thus, abnormal DA was detected in 115 of 127 AMD patients, and normal DA was found in 19 of 21 normal adults. The high diagnostic sensitivity and specificity compared favorably to long-duration research methods for the measurement of DA, and slit lamp biomicroscopy performed by a retina specialist. These results suggest that a rapid DA test is useful for the detection of AMD.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1552-5783
1552-5783
DOI:10.1167/iovs.13-13745