Thy-1 Regulates VEGF-Mediated Choroidal Endothelial Cell Activation and Migration: Implications in Neovascular Age-Related Macular Degeneration

This study addresses the hypothesis that age-related stresses upregulate Thy-1 in choroidal endothelial cells (CECs) and contribute to CEC activation and migration, processes important in choroidal neovascularization (CNV). Measurements were made of Thy-1 protein (Western blot) in CECs and Thy-1 mRN...

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Veröffentlicht in:	Investigative ophthalmology & visual science Jg. 57; H. 13; S. 5525 - 5534
Hauptverfasser:	Wang, Haibo, Han, Xiaokun, Kunz, Eric, Hartnett, M. Elizabeth
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States The Association for Research in Vision and Ophthalmology 01.10.2016
Schlagworte:	Adult Aged Aged, 80 and over Animals Blotting, Western Cell Movement Cell Proliferation Cells, Cultured Choroid - blood supply Choroid - metabolism Choroidal Neovascularization - diagnosis Choroidal Neovascularization - genetics Choroidal Neovascularization - metabolism Disease Models, Animal Endothelial Cells - metabolism Endothelial Cells - pathology Female Gene Expression Regulation Humans Macular Degeneration - diagnosis Macular Degeneration - genetics Macular Degeneration - metabolism Male Mice Mice, Inbred C57BL Middle Aged Real-Time Polymerase Chain Reaction Retinal Cell Biology Retinal Pigment Epithelium - metabolism Retinal Pigment Epithelium - pathology RNA, Messenger - genetics Signal Transduction Thy-1 Antigens - biosynthesis Thy-1 Antigens - genetics Tissue Donors Up-Regulation Vascular Endothelial Growth Factor A - metabolism Young Adult
ISSN:	1552-5783, 0146-0404, 1552-5783
Online-Zugang:	Volltext
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