Differential protein–protein interactions of full length human FasL and FasL fragments generated by proteolysis

Fas ligand (FasL) is a death factor of the tumor necrosis factor superfamily. Like other members of this family of type II transmembrane proteins, FasL is subject to ectodomain shedding by a disintegrin and metalloproteinases (ADAMs) liberating soluble FasL and leaving membrane-integral N-terminal f...

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Veröffentlicht in:	Experimental cell research Jg. 320; H. 2; S. 290 - 301
Hauptverfasser:	Lettau, Marcus, Voss, Matthias, Ebsen, Henriette, Kabelitz, Dieter, Janssen, Ottmar
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 15.01.2014 Elsevier BV
Schlagworte:	Animals Biomedical research Cells, Cultured Fas Ligand Protein - chemistry Fas Ligand Protein - metabolism FasL HEK293 Cells Humans Intramembrane proteolysis Jurkat Cells K562 Cells Mice Mice, Inbred BALB C Monoclonal antibody PCH proteins Peptide Fragments - chemistry Peptide Fragments - metabolism Protein Binding - physiology Protein expression Protein Interaction Domains and Motifs - physiology Protein Interaction Mapping Protein–protein interaction Proteolysis Proteomics Signal transduction Sorting nexins Studies Substrate Specificity T lymphocytes Tumors T lymphocytes NTF PCH proteins (F-)BAR PRD ESCRT SPPL2a ICD Monoclonal antibody TNF Intramembrane proteolysis Protein–protein interaction mab ADAM Signal transduction Sorting nexins PCH FasL Proteolysis RIP SNX I-CLiP SH3 Fas ligand (Fer/CIP4 homology-)Bin–Amphiphysin–Rvs Pombe Cdc15 homology intracellular domain endosomal sorting complexes required for transport intramembrane-cleaving protease proline-rich domain Src homology 3 regulated intramembrane proteolysis sorting nexin N-terminal fragment a disintegrin and metalloproteinase signal peptide peptidase like 2a tumor necrosis factor
ISSN:	0014-4827, 1090-2422, 1090-2422
Online-Zugang:	Volltext
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