Mitochondrial peptides modulate mitochondrial function during cellular senescence

Cellular senescence is a complex cell fate response that is thought to underlie several age-related pathologies. Despite a loss of proliferative potential, senescent cells are metabolically active and produce energy-consuming effectors, including senescence-associated secretory phenotypes (SASPs). M...

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Bibliographic Details
Published in:	Aging (Albany, NY.) Vol. 10; no. 6; p. 1239
Main Authors:	Kim, Su-Jeong, Mehta, Hemal H, Wan, Junxiang, Kuehnemann, Chisaka, Chen, Jingcheng, Hu, Ji-Fan, Hoffman, Andrew R, Cohen, Pinchas
Format:	Journal Article
Language:	English
Published:	United States 10.06.2018
Subjects:	Carbamates - metabolism Cells, Cultured Cellular Senescence - physiology DNA Copy Number Variations DNA, Mitochondrial - genetics Fibroblasts Gene Expression Regulation - physiology Humans Mitochondria - metabolism Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Sulfonamides - metabolism senescence SASP (senescence-associated secretory phenotype) mitochondrial energetics mitochondrial-derived peptides mitochondria mtDNA methylation
ISSN:	1945-4589, 1945-4589
Online Access:	Get more information
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