Interferon-stimulated gene 15 accelerates replication fork progression inducing chromosomal breakage

DNA replication is highly regulated by the ubiquitin system, which plays key roles upon stress. The ubiquitin-like modifier ISG15 (interferon-stimulated gene 15) is induced by interferons, bacterial and viral infection, and DNA damage, but it is also constitutively expressed in many types of cancer,...

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Bibliographic Details
Published in:	The Journal of cell biology Vol. 219; no. 8
Main Authors:	Raso, Maria Chiara, Djoric, Nikola, Walser, Franziska, Hess, Sandra, Schmid, Fabian Marc, Burger, Sibylle, Knobeloch, Klaus-Peter, Penengo, Lorenza
Format:	Journal Article
Language:	English
Published:	United States 03.08.2020
Subjects:	Antineoplastic Agents - pharmacology Bone Neoplasms - drug therapy Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Chromosome Breakage Cytokines - genetics Cytokines - metabolism DNA Damage DNA Replication DNA, Neoplasm - biosynthesis DNA, Neoplasm - genetics Dose-Response Relationship, Drug HEK293 Cells HeLa Cells Humans MCF-7 Cells Osteosarcoma - drug therapy Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism RecQ Helicases - genetics RecQ Helicases - metabolism Time Factors Ubiquitins - genetics Ubiquitins - metabolism
ISSN:	1540-8140, 1540-8140
Online Access:	Get more information
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