Superficial CD34‐positive fibroblastic tumor and PRDM10‐rearranged soft tissue tumor are overlapping entities: a comprehensive study of 20 cases
Aims Superficial CD34‐positive fibroblastic tumor (SCD34FT) and PRDM10‐rearranged soft tissue tumor (PRDM10‐STT) are rare mesenchymal tumors. These lesions have clinicopathological similarities, but their relationship remains controversial. This study aimed to characterise a series of cases of SCD34...
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| Veröffentlicht in: | Histopathology Jg. 79; H. 5; S. 810 - 825 |
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| Sprache: | Englisch |
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England
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01.11.2021
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| ISSN: | 0309-0167, 1365-2559, 1365-2559 |
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| Abstract | Aims
Superficial CD34‐positive fibroblastic tumor (SCD34FT) and PRDM10‐rearranged soft tissue tumor (PRDM10‐STT) are rare mesenchymal tumors. These lesions have clinicopathological similarities, but their relationship remains controversial. This study aimed to characterise a series of cases of SCD34FT and PRDM10‐STT.
Methods and results
Ten lesions each of SCD34FT and PRDM10‐STT were studied using immunohistochemistry, array‐comparative genomic hybridisation (aCGH), RNA sequencing and exome sequencing. Tumors mainly occurred in young adults, were generally small (< 5 cm) and arose predominantly in the superficial soft tissues of the lower extremities. Follow‐up data were available in 15 cases (SCD34FT, n = 7, median 16 months; PRDM10‐STT, n = 8, median 14 months), local recurrences occurred in four cases (SCD34FT, two of 10; PRDM10‐STT, two of 10), while no distant spread was documented. Morphologically, tumors were relatively well‐circumscribed and composed of sheets and fascicles of spindle and pleomorphic cells showing low mitotic activity (< 1/mm²) without necrosis. Other findings included: granular cell change, lipoblast‐like cells, ectatic blood vessels with fibrinous material, myxoid stromal changes, metaplastic bone and increased mitotic activity (> 1/mm²). All tumors diffusely expressed CD34, while pan‐keratin and desmin were commonly seen focally. SynCAM3 was diffusely expressed in 12 cases (SCD34FT, n = 5; PRDM10‐STT, n = 7), independently of fusion status. aCGH profiles were ‘flat’ (PRDM10‐STT, n = 4; SCD34FT, n = 2) and exome sequencing showed no recurrent pathogenic mutations (PRDM10‐STT, n = 2; SCD34FT, n = 4). Overall, the only morphological features seen exclusively in PRDM10‐STT were myxoid stromal changes (three of 10) and metaplastic bone (two of 10).
Conclusion
We expand the current knowledge on PRDM10‐STT and SCD34FT and provide additional evidence for considering them as overlapping entities. |
|---|---|
| AbstractList | Aims
Superficial CD34‐positive fibroblastic tumor (SCD34FT) and PRDM10‐rearranged soft tissue tumor (PRDM10‐STT) are rare mesenchymal tumors. These lesions have clinicopathological similarities, but their relationship remains controversial. This study aimed to characterise a series of cases of SCD34FT and PRDM10‐STT.
Methods and results
Ten lesions each of SCD34FT and PRDM10‐STT were studied using immunohistochemistry, array‐comparative genomic hybridisation (aCGH), RNA sequencing and exome sequencing. Tumors mainly occurred in young adults, were generally small (< 5 cm) and arose predominantly in the superficial soft tissues of the lower extremities. Follow‐up data were available in 15 cases (SCD34FT, n = 7, median 16 months; PRDM10‐STT, n = 8, median 14 months), local recurrences occurred in four cases (SCD34FT, two of 10; PRDM10‐STT, two of 10), while no distant spread was documented. Morphologically, tumors were relatively well‐circumscribed and composed of sheets and fascicles of spindle and pleomorphic cells showing low mitotic activity (< 1/mm²) without necrosis. Other findings included: granular cell change, lipoblast‐like cells, ectatic blood vessels with fibrinous material, myxoid stromal changes, metaplastic bone and increased mitotic activity (> 1/mm²). All tumors diffusely expressed CD34, while pan‐keratin and desmin were commonly seen focally. SynCAM3 was diffusely expressed in 12 cases (SCD34FT, n = 5; PRDM10‐STT, n = 7), independently of fusion status. aCGH profiles were ‘flat’ (PRDM10‐STT, n = 4; SCD34FT, n = 2) and exome sequencing showed no recurrent pathogenic mutations (PRDM10‐STT, n = 2; SCD34FT, n = 4). Overall, the only morphological features seen exclusively in PRDM10‐STT were myxoid stromal changes (three of 10) and metaplastic bone (two of 10).
Conclusion
We expand the current knowledge on PRDM10‐STT and SCD34FT and provide additional evidence for considering them as overlapping entities. Superficial CD34-positive fibroblastic tumor (SCD34FT) and PRDM10-rearranged soft tissue tumor (PRDM10-STT) are rare mesenchymal tumors. These lesions have clinicopathological similarities, but their relationship remains controversial. This study aimed to characterise a series of cases of SCD34FT and PRDM10-STT.AIMSSuperficial CD34-positive fibroblastic tumor (SCD34FT) and PRDM10-rearranged soft tissue tumor (PRDM10-STT) are rare mesenchymal tumors. These lesions have clinicopathological similarities, but their relationship remains controversial. This study aimed to characterise a series of cases of SCD34FT and PRDM10-STT.Ten lesions each of SCD34FT and PRDM10-STT were studied using immunohistochemistry, array-comparative genomic hybridisation (aCGH), RNA sequencing and exome sequencing. Tumors mainly occurred in young adults, were generally small (< 5 cm) and arose predominantly in the superficial soft tissues of the lower extremities. Follow-up data were available in 15 cases (SCD34FT, n = 7, median 16 months; PRDM10-STT, n = 8, median 14 months), local recurrences occurred in four cases (SCD34FT, two of 10; PRDM10-STT, two of 10), while no distant spread was documented. Morphologically, tumors were relatively well-circumscribed and composed of sheets and fascicles of spindle and pleomorphic cells showing low mitotic activity (< 1/mm²) without necrosis. Other findings included: granular cell change, lipoblast-like cells, ectatic blood vessels with fibrinous material, myxoid stromal changes, metaplastic bone and increased mitotic activity (> 1/mm²). All tumors diffusely expressed CD34, while pan-keratin and desmin were commonly seen focally. SynCAM3 was diffusely expressed in 12 cases (SCD34FT, n = 5; PRDM10-STT, n = 7), independently of fusion status. aCGH profiles were 'flat' (PRDM10-STT, n = 4; SCD34FT, n = 2) and exome sequencing showed no recurrent pathogenic mutations (PRDM10-STT, n = 2; SCD34FT, n = 4). Overall, the only morphological features seen exclusively in PRDM10-STT were myxoid stromal changes (three of 10) and metaplastic bone (two of 10).METHODS AND RESULTSTen lesions each of SCD34FT and PRDM10-STT were studied using immunohistochemistry, array-comparative genomic hybridisation (aCGH), RNA sequencing and exome sequencing. Tumors mainly occurred in young adults, were generally small (< 5 cm) and arose predominantly in the superficial soft tissues of the lower extremities. Follow-up data were available in 15 cases (SCD34FT, n = 7, median 16 months; PRDM10-STT, n = 8, median 14 months), local recurrences occurred in four cases (SCD34FT, two of 10; PRDM10-STT, two of 10), while no distant spread was documented. Morphologically, tumors were relatively well-circumscribed and composed of sheets and fascicles of spindle and pleomorphic cells showing low mitotic activity (< 1/mm²) without necrosis. Other findings included: granular cell change, lipoblast-like cells, ectatic blood vessels with fibrinous material, myxoid stromal changes, metaplastic bone and increased mitotic activity (> 1/mm²). All tumors diffusely expressed CD34, while pan-keratin and desmin were commonly seen focally. SynCAM3 was diffusely expressed in 12 cases (SCD34FT, n = 5; PRDM10-STT, n = 7), independently of fusion status. aCGH profiles were 'flat' (PRDM10-STT, n = 4; SCD34FT, n = 2) and exome sequencing showed no recurrent pathogenic mutations (PRDM10-STT, n = 2; SCD34FT, n = 4). Overall, the only morphological features seen exclusively in PRDM10-STT were myxoid stromal changes (three of 10) and metaplastic bone (two of 10).We expand the current knowledge on PRDM10-STT and SCD34FT and provide additional evidence for considering them as overlapping entities.CONCLUSIONWe expand the current knowledge on PRDM10-STT and SCD34FT and provide additional evidence for considering them as overlapping entities. Superficial CD34-positive fibroblastic tumor (SCD34FT) and PRDM10-rearranged soft tissue tumor (PRDM10-STT) are rare mesenchymal tumors. These lesions have clinicopathological similarities, but their relationship remains controversial. This study aimed to characterise a series of cases of SCD34FT and PRDM10-STT. Ten lesions each of SCD34FT and PRDM10-STT were studied using immunohistochemistry, array-comparative genomic hybridisation (aCGH), RNA sequencing and exome sequencing. Tumors mainly occurred in young adults, were generally small (< 5 cm) and arose predominantly in the superficial soft tissues of the lower extremities. Follow-up data were available in 15 cases (SCD34FT, n = 7, median 16 months; PRDM10-STT, n = 8, median 14 months), local recurrences occurred in four cases (SCD34FT, two of 10; PRDM10-STT, two of 10), while no distant spread was documented. Morphologically, tumors were relatively well-circumscribed and composed of sheets and fascicles of spindle and pleomorphic cells showing low mitotic activity (< 1/mm²) without necrosis. Other findings included: granular cell change, lipoblast-like cells, ectatic blood vessels with fibrinous material, myxoid stromal changes, metaplastic bone and increased mitotic activity (> 1/mm²). All tumors diffusely expressed CD34, while pan-keratin and desmin were commonly seen focally. SynCAM3 was diffusely expressed in 12 cases (SCD34FT, n = 5; PRDM10-STT, n = 7), independently of fusion status. aCGH profiles were 'flat' (PRDM10-STT, n = 4; SCD34FT, n = 2) and exome sequencing showed no recurrent pathogenic mutations (PRDM10-STT, n = 2; SCD34FT, n = 4). Overall, the only morphological features seen exclusively in PRDM10-STT were myxoid stromal changes (three of 10) and metaplastic bone (two of 10). We expand the current knowledge on PRDM10-STT and SCD34FT and provide additional evidence for considering them as overlapping entities. AimsSuperficial CD34‐positive fibroblastic tumor (SCD34FT) and PRDM10‐rearranged soft tissue tumor (PRDM10‐STT) are rare mesenchymal tumors. These lesions have clinicopathological similarities, but their relationship remains controversial. This study aimed to characterise a series of cases of SCD34FT and PRDM10‐STT.Methods and resultsTen lesions each of SCD34FT and PRDM10‐STT were studied using immunohistochemistry, array‐comparative genomic hybridisation (aCGH), RNA sequencing and exome sequencing. Tumors mainly occurred in young adults, were generally small (< 5 cm) and arose predominantly in the superficial soft tissues of the lower extremities. Follow‐up data were available in 15 cases (SCD34FT, n = 7, median 16 months; PRDM10‐STT, n = 8, median 14 months), local recurrences occurred in four cases (SCD34FT, two of 10; PRDM10‐STT, two of 10), while no distant spread was documented. Morphologically, tumors were relatively well‐circumscribed and composed of sheets and fascicles of spindle and pleomorphic cells showing low mitotic activity (< 1/mm²) without necrosis. Other findings included: granular cell change, lipoblast‐like cells, ectatic blood vessels with fibrinous material, myxoid stromal changes, metaplastic bone and increased mitotic activity (> 1/mm²). All tumors diffusely expressed CD34, while pan‐keratin and desmin were commonly seen focally. SynCAM3 was diffusely expressed in 12 cases (SCD34FT, n = 5; PRDM10‐STT, n = 7), independently of fusion status. aCGH profiles were ‘flat’ (PRDM10‐STT, n = 4; SCD34FT, n = 2) and exome sequencing showed no recurrent pathogenic mutations (PRDM10‐STT, n = 2; SCD34FT, n = 4). Overall, the only morphological features seen exclusively in PRDM10‐STT were myxoid stromal changes (three of 10) and metaplastic bone (two of 10).ConclusionWe expand the current knowledge on PRDM10‐STT and SCD34FT and provide additional evidence for considering them as overlapping entities. |
| Author | Le Loarer, François Meurgey, Alexandra Charon‐Barra, Céline Perret, Raul Baud, Jessica Michal, Michael Pissaloux, Daniel Coindre, Jean‐Michel Tirode, Franck Soubeyran, Isabelle Velasco, Valérie Boidot, Romain Geneste, Damien Weingertner, Noelle Paindavoine, Sandrine Karanian, Marie Carr, Richard A Švajdler, Marian |
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| Copyright | 2021 John Wiley & Sons Ltd 2021 John Wiley & Sons Ltd. Copyright © 2021 John Wiley & Sons Ltd Distributed under a Creative Commons Attribution 4.0 International License |
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| Keywords | RNA sequencing comparative genomic hybridisation sarcoma superficial CD34-positive fibroblastic tumor PRDM10 |
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Superficial CD34‐positive fibroblastic tumor (SCD34FT) and PRDM10‐rearranged soft tissue tumor (PRDM10‐STT) are rare mesenchymal tumors. These lesions... Superficial CD34-positive fibroblastic tumor (SCD34FT) and PRDM10-rearranged soft tissue tumor (PRDM10-STT) are rare mesenchymal tumors. These lesions have... AimsSuperficial CD34‐positive fibroblastic tumor (SCD34FT) and PRDM10‐rearranged soft tissue tumor (PRDM10‐STT) are rare mesenchymal tumors. These lesions have... |
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| SubjectTerms | Adolescent Adult Antigens, CD34 - metabolism Biomarkers, Tumor Blood vessels Bone tumors Cancer CD34 antigen comparative genomic hybridisation Desmin DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Fibroblasts - pathology Gene Rearrangement Humans Hybridization Immunohistochemistry Keratin Life Sciences Male Mesenchyme Middle Aged PRDM10 RNA sequencing sarcoma Soft Tissue Neoplasms - genetics Soft Tissue Neoplasms - metabolism Soft Tissue Neoplasms - pathology Soft tissues superficial CD34‐positive fibroblastic tumor Transcription Factors - genetics Transcription Factors - metabolism Tumors Young Adult Young adults |
| Title | Superficial CD34‐positive fibroblastic tumor and PRDM10‐rearranged soft tissue tumor are overlapping entities: a comprehensive study of 20 cases |
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