Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope

Experimental leishmaniasis offers a well characterized model of T helper type 1 cell (Th1)-mediated control of infection by an intracellular organism. Susceptible BALB/c mice aberrantly develop Th2 cells in response to infection and are unable to control parasite dissemination. The early CD4(+) T ce...

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Bibliographic Details
Published in:	The Journal of experimental medicine Vol. 189; no. 7; p. 1111
Main Authors:	Pingel, S, Launois, P, Fowell, D J, Turck, C W, Southwood, S, Sette, A, Glaichenhaus, N, Louis, J A, Locksley, R M
Format:	Journal Article
Language:	English
Published:	United States 05.04.1999
Subjects:	Amino Acid Sequence Amino Acid Substitution Animals Antigens, Protozoan - immunology Disease Susceptibility Epitopes - immunology Female Histocompatibility Antigens Class II - immunology Immune Tolerance Immunity, Cellular Interferon-gamma - metabolism Interleukin-4 - metabolism Leishmania major - immunology Leishmaniasis, Cutaneous - immunology Ligands Lymphocyte Activation Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic Molecular Sequence Data Peptide Fragments - chemical synthesis Peptide Fragments - immunology Protozoan Proteins - chemistry Protozoan Proteins - immunology Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - immunology Recombinant Fusion Proteins - immunology Superantigens - immunology Th2 Cells - immunology
ISSN:	0022-1007
Online Access:	Get more information
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