Assessment of toxicological potential of sodium carboxymethyl beta-glucan, a novel beta-glucan

In this experimental work, sodium carboxymethyl beta-glucan (CMBG), a chemically altered beta-glucan, is evaluated for mutagenicity and sub-acute oral toxicity. Specifically, the tested material was CM-Glucan Nu, a food grade powder ≥90% CMBG derived from Saccharomyces cerevisiae. A bacterial revers...

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Vydané v:Food and chemical toxicology Ročník 152; s. 112226
Hlavní autori: Preece, Kayla E., Glávits, Róbert, Murbach, Timothy S., Endres, John R., Hirka, Gábor, Vértesi, Adél, Szakonyiné, Ilona Pasics
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Elsevier Ltd 01.06.2021
Predmet:
Administration, Oral
Animals
beta-glucans
beta-Glucans - administration & dosage
beta-Glucans - toxicity
Escherichia coli - drug effects
Female
females
Male
males
mortality
Mutagenicity
Mutagenicity Tests
mutation
No-Observed-Adverse-Effect Level
NOAEL
Rats
Rats, Wistar
Saccharomyces cerevisiae
Saccharomyces cerevisiae - chemistry
Safety
Salmonella typhimurium - drug effects
sodium
Sodium carboxymethyl beta-glucan
Toxicity
toxicity testing
Toxicity Tests, Subacute
Mutagenicity
Safety
Toxicity
Sodium carboxymethyl beta-glucan
NOAEL
ISSN:0278-6915, 1873-6351, 1873-6351
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Shrnutí:In this experimental work, sodium carboxymethyl beta-glucan (CMBG), a chemically altered beta-glucan, is evaluated for mutagenicity and sub-acute oral toxicity. Specifically, the tested material was CM-Glucan Nu, a food grade powder ≥90% CMBG derived from Saccharomyces cerevisiae. A bacterial reverse mutation test was performed and resulted in no mutagenicity. A 28-day, repeated-dose, oral (gavage) toxicity test on rats was performed at dose levels of 0, 500, 1000, and 2000 mg/kg bw/day. No mortality, target organs or other treatment related effects were observed. The no observed adverse effect level (NOAEL) was 2000 mg/kg bw/day, the highest dose tested, for both male and female Han:WIST rats. •Sodium carboxymethyl beta-glucan is without mutagenicity under the experimental conditions applied.•The no observed adverse effect level of an OECD, 28-day toxicological study was 2000 mg/kg bw/day.•The findings contribute to the safety evaluation of carboxymethyl beta-glucan.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0278-6915
1873-6351
1873-6351
DOI:10.1016/j.fct.2021.112226