Assessment of toxicological potential of sodium carboxymethyl beta-glucan, a novel beta-glucan

In this experimental work, sodium carboxymethyl beta-glucan (CMBG), a chemically altered beta-glucan, is evaluated for mutagenicity and sub-acute oral toxicity. Specifically, the tested material was CM-Glucan Nu, a food grade powder ≥90% CMBG derived from Saccharomyces cerevisiae. A bacterial revers...

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Published in:	Food and chemical toxicology Vol. 152; p. 112226
Main Authors:	Preece, Kayla E., Glávits, Róbert, Murbach, Timothy S., Endres, John R., Hirka, Gábor, Vértesi, Adél, Szakonyiné, Ilona Pasics
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.06.2021
Subjects:	Administration, Oral Animals beta-glucans beta-Glucans - administration & dosage beta-Glucans - toxicity Escherichia coli - drug effects Female females Male males mortality Mutagenicity Mutagenicity Tests mutation No-Observed-Adverse-Effect Level NOAEL Rats Rats, Wistar Saccharomyces cerevisiae Saccharomyces cerevisiae - chemistry Safety Salmonella typhimurium - drug effects sodium Sodium carboxymethyl beta-glucan Toxicity toxicity testing Toxicity Tests, Subacute Mutagenicity Safety Toxicity Sodium carboxymethyl beta-glucan NOAEL
ISSN:	0278-6915, 1873-6351, 1873-6351
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Abstract	In this experimental work, sodium carboxymethyl beta-glucan (CMBG), a chemically altered beta-glucan, is evaluated for mutagenicity and sub-acute oral toxicity. Specifically, the tested material was CM-Glucan Nu, a food grade powder ≥90% CMBG derived from Saccharomyces cerevisiae. A bacterial reverse mutation test was performed and resulted in no mutagenicity. A 28-day, repeated-dose, oral (gavage) toxicity test on rats was performed at dose levels of 0, 500, 1000, and 2000 mg/kg bw/day. No mortality, target organs or other treatment related effects were observed. The no observed adverse effect level (NOAEL) was 2000 mg/kg bw/day, the highest dose tested, for both male and female Han:WIST rats. •Sodium carboxymethyl beta-glucan is without mutagenicity under the experimental conditions applied.•The no observed adverse effect level of an OECD, 28-day toxicological study was 2000 mg/kg bw/day.•The findings contribute to the safety evaluation of carboxymethyl beta-glucan.
AbstractList	In this experimental work, sodium carboxymethyl beta-glucan (CMBG), a chemically altered beta-glucan, is evaluated for mutagenicity and sub-acute oral toxicity. Specifically, the tested material was CM-Glucan Nu, a food grade powder ≥90% CMBG derived from Saccharomyces cerevisiae. A bacterial reverse mutation test was performed and resulted in no mutagenicity. A 28-day, repeated-dose, oral (gavage) toxicity test on rats was performed at dose levels of 0, 500, 1000, and 2000 mg/kg bw/day. No mortality, target organs or other treatment related effects were observed. The no observed adverse effect level (NOAEL) was 2000 mg/kg bw/day, the highest dose tested, for both male and female Han:WIST rats. •Sodium carboxymethyl beta-glucan is without mutagenicity under the experimental conditions applied.•The no observed adverse effect level of an OECD, 28-day toxicological study was 2000 mg/kg bw/day.•The findings contribute to the safety evaluation of carboxymethyl beta-glucan. In this experimental work, sodium carboxymethyl beta-glucan (CMBG), a chemically altered beta-glucan, is evaluated for mutagenicity and sub-acute oral toxicity. Specifically, the tested material was CM-Glucan Nu, a food grade powder ≥90% CMBG derived from Saccharomyces cerevisiae. A bacterial reverse mutation test was performed and resulted in no mutagenicity. A 28-day, repeated-dose, oral (gavage) toxicity test on rats was performed at dose levels of 0, 500, 1000, and 2000 mg/kg bw/day. No mortality, target organs or other treatment related effects were observed. The no observed adverse effect level (NOAEL) was 2000 mg/kg bw/day, the highest dose tested, for both male and female Han:WIST rats. In this experimental work, sodium carboxymethyl beta-glucan (CMBG), a chemically altered beta-glucan, is evaluated for mutagenicity and sub-acute oral toxicity. Specifically, the tested material was CM-Glucan Nu, a food grade powder ≥90% CMBG derived from Saccharomyces cerevisiae. A bacterial reverse mutation test was performed and resulted in no mutagenicity. A 28-day, repeated-dose, oral (gavage) toxicity test on rats was performed at dose levels of 0, 500, 1000, and 2000 mg/kg bw/day. No mortality, target organs or other treatment related effects were observed. The no observed adverse effect level (NOAEL) was 2000 mg/kg bw/day, the highest dose tested, for both male and female Han:WIST rats. In this experimental work, sodium carboxymethyl beta-glucan (CMBG), a chemically altered beta-glucan, is evaluated for mutagenicity and sub-acute oral toxicity. Specifically, the tested material was CM-Glucan Nu, a food grade powder ≥90% CMBG derived from Saccharomyces cerevisiae. A bacterial reverse mutation test was performed and resulted in no mutagenicity. A 28-day, repeated-dose, oral (gavage) toxicity test on rats was performed at dose levels of 0, 500, 1000, and 2000 mg/kg bw/day. No mortality, target organs or other treatment related effects were observed. The no observed adverse effect level (NOAEL) was 2000 mg/kg bw/day, the highest dose tested, for both male and female Han:WIST rats.In this experimental work, sodium carboxymethyl beta-glucan (CMBG), a chemically altered beta-glucan, is evaluated for mutagenicity and sub-acute oral toxicity. Specifically, the tested material was CM-Glucan Nu, a food grade powder ≥90% CMBG derived from Saccharomyces cerevisiae. A bacterial reverse mutation test was performed and resulted in no mutagenicity. A 28-day, repeated-dose, oral (gavage) toxicity test on rats was performed at dose levels of 0, 500, 1000, and 2000 mg/kg bw/day. No mortality, target organs or other treatment related effects were observed. The no observed adverse effect level (NOAEL) was 2000 mg/kg bw/day, the highest dose tested, for both male and female Han:WIST rats.
ArticleNumber	112226
Author	Hirka, Gábor Murbach, Timothy S. Endres, John R. Glávits, Róbert Szakonyiné, Ilona Pasics Preece, Kayla E. Vértesi, Adél
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Keywords	Mutagenicity Safety Toxicity Sodium carboxymethyl beta-glucan NOAEL
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SubjectTerms	Administration, Oral Animals beta-glucans beta-Glucans - administration & dosage beta-Glucans - toxicity Escherichia coli - drug effects Female females Male males mortality Mutagenicity Mutagenicity Tests mutation No-Observed-Adverse-Effect Level NOAEL Rats Rats, Wistar Saccharomyces cerevisiae Saccharomyces cerevisiae - chemistry Safety Salmonella typhimurium - drug effects sodium Sodium carboxymethyl beta-glucan Toxicity toxicity testing Toxicity Tests, Subacute
Title	Assessment of toxicological potential of sodium carboxymethyl beta-glucan, a novel beta-glucan
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