Cohort Profile: Generation Scotland: Scottish Family Health Study (GS:SFHS). The study, its participants and their potential for genetic research on health and illness

GS:SFHS is a family-based genetic epidemiology study with DNA and socio-demographic and clinical data from about 24 000 volunteers across Scotland aged 18-98 years, from February 2006 to March 2011. Biological samples and anonymized data form a resource for research on the genetics of health, diseas...

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Published in:International journal of epidemiology Vol. 42; no. 3; p. 689
Main Authors: Smith, Blair H, Campbell, Archie, Linksted, Pamela, Fitzpatrick, Bridie, Jackson, Cathy, Kerr, Shona M, Deary, Ian J, Macintyre, Donald J, Campbell, Harry, McGilchrist, Mark, Hocking, Lynne J, Wisely, Lucy, Ford, Ian, Lindsay, Robert S, Morton, Robin, Palmer, Colin N A, Dominiczak, Anna F, Porteous, David J, Morris, Andrew D
Format: Journal Article
Language:English
Published: England 01.06.2013
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Cognition
Cohort Studies
DNA - analysis
Family Health - statistics & numerical data
Female
Genetic Predisposition to Disease
Genetic Research
Humans
Male
Medical Record Linkage
Mental Health
Middle Aged
Molecular Epidemiology
Pedigree
Phenotype
Risk Factors
Scotland - epidemiology
Socioeconomic Factors
Surveys and Questionnaires
Young Adult
Scotland
ISSN:1464-3685, 1464-3685
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Abstract GS:SFHS is a family-based genetic epidemiology study with DNA and socio-demographic and clinical data from about 24 000 volunteers across Scotland aged 18-98 years, from February 2006 to March 2011. Biological samples and anonymized data form a resource for research on the genetics of health, disease and quantitative traits of current and projected public health importance. Specific and important features of GS:SFHS include the family-based recruitment, with the intent of obtaining family groups; the breadth and depth of phenotype information, including detailed data on cognitive function, personality traits and mental health; consent and mechanisms for linkage of all data to comprehensive routine health-care records; and 'broad' consent from participants to use their data and samples for a wide range of medical research, including commercial research, and for re-contact for the potential collection of other data or samples, or for participation in related studies and the design and review of the protocol in parallel with in-depth sociological research on (potential) participants and users of the research outcomes. These features were designed to maximize the power of the resource to identify, replicate or control for genetic factors associated with a wide spectrum of illnesses and risk factors, both now and in the future.
AbstractList GS:SFHS is a family-based genetic epidemiology study with DNA and socio-demographic and clinical data from about 24 000 volunteers across Scotland aged 18-98 years, from February 2006 to March 2011. Biological samples and anonymized data form a resource for research on the genetics of health, disease and quantitative traits of current and projected public health importance. Specific and important features of GS:SFHS include the family-based recruitment, with the intent of obtaining family groups; the breadth and depth of phenotype information, including detailed data on cognitive function, personality traits and mental health; consent and mechanisms for linkage of all data to comprehensive routine health-care records; and 'broad' consent from participants to use their data and samples for a wide range of medical research, including commercial research, and for re-contact for the potential collection of other data or samples, or for participation in related studies and the design and review of the protocol in parallel with in-depth sociological research on (potential) participants and users of the research outcomes. These features were designed to maximize the power of the resource to identify, replicate or control for genetic factors associated with a wide spectrum of illnesses and risk factors, both now and in the future.GS:SFHS is a family-based genetic epidemiology study with DNA and socio-demographic and clinical data from about 24 000 volunteers across Scotland aged 18-98 years, from February 2006 to March 2011. Biological samples and anonymized data form a resource for research on the genetics of health, disease and quantitative traits of current and projected public health importance. Specific and important features of GS:SFHS include the family-based recruitment, with the intent of obtaining family groups; the breadth and depth of phenotype information, including detailed data on cognitive function, personality traits and mental health; consent and mechanisms for linkage of all data to comprehensive routine health-care records; and 'broad' consent from participants to use their data and samples for a wide range of medical research, including commercial research, and for re-contact for the potential collection of other data or samples, or for participation in related studies and the design and review of the protocol in parallel with in-depth sociological research on (potential) participants and users of the research outcomes. These features were designed to maximize the power of the resource to identify, replicate or control for genetic factors associated with a wide spectrum of illnesses and risk factors, both now and in the future.
GS:SFHS is a family-based genetic epidemiology study with DNA and socio-demographic and clinical data from about 24 000 volunteers across Scotland aged 18-98 years, from February 2006 to March 2011. Biological samples and anonymized data form a resource for research on the genetics of health, disease and quantitative traits of current and projected public health importance. Specific and important features of GS:SFHS include the family-based recruitment, with the intent of obtaining family groups; the breadth and depth of phenotype information, including detailed data on cognitive function, personality traits and mental health; consent and mechanisms for linkage of all data to comprehensive routine health-care records; and 'broad' consent from participants to use their data and samples for a wide range of medical research, including commercial research, and for re-contact for the potential collection of other data or samples, or for participation in related studies and the design and review of the protocol in parallel with in-depth sociological research on (potential) participants and users of the research outcomes. These features were designed to maximize the power of the resource to identify, replicate or control for genetic factors associated with a wide spectrum of illnesses and risk factors, both now and in the future.
Author Deary, Ian J
Jackson, Cathy
McGilchrist, Mark
Linksted, Pamela
Macintyre, Donald J
Campbell, Harry
Hocking, Lynne J
Campbell, Archie
Porteous, David J
Morris, Andrew D
Smith, Blair H
Dominiczak, Anna F
Lindsay, Robert S
Wisely, Lucy
Morton, Robin
Kerr, Shona M
Fitzpatrick, Bridie
Ford, Ian
Palmer, Colin N A
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  organization: Medical Research Institute, University of Dundee, Dundee, UK. b.h.smith@dundee.ac.uk
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  givenname: Archie
  surname: Campbell
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/22786799$$D View this record in MEDLINE/PubMed
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PublicationTitle International journal of epidemiology
PublicationTitleAlternate Int J Epidemiol
PublicationYear 2013
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Snippet GS:SFHS is a family-based genetic epidemiology study with DNA and socio-demographic and clinical data from about 24 000 volunteers across Scotland aged 18-98...
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SubjectTerms Adolescent
Adult
Aged
Aged, 80 and over
Cognition
Cohort Studies
DNA - analysis
Family Health - statistics & numerical data
Female
Genetic Predisposition to Disease
Genetic Research
Humans
Male
Medical Record Linkage
Mental Health
Middle Aged
Molecular Epidemiology
Pedigree
Phenotype
Risk Factors
Scotland - epidemiology
Socioeconomic Factors
Surveys and Questionnaires
Young Adult
Title Cohort Profile: Generation Scotland: Scottish Family Health Study (GS:SFHS). The study, its participants and their potential for genetic research on health and illness
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