Comparison of the Uptake of Hepatocellular Carcinoma on Pre-Therapeutic MDCT, CACT, and SPECT/CT, and the Correlation with Post-Therapeutic PET/CT in Patients Undergoing Selective Internal Radiation Therapy

(1) Background: To comparatively analyze the uptake of hepatocellular carcinoma (HCC) on pre-therapeutic imaging modalities, the arterial phase multi-detector computed tomography (MDCT), the parenchymal phase C-arm computed tomography (CACT), the Technetium99m-macroaggregates of human serum albumin...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Journal of clinical medicine Ročník 10; číslo 17; s. 3837
Hlavní autori:	Meine, Timo C., Brunkhorst, Thomas, Werncke, Thomas, Schütze, Christian, Vogel, Arndt, Kirstein, Martha M., Dewald, Cornelia L. A., Becker, Lena S., Maschke, Sabine K., Kretschmann, Nils, Wacker, Frank K., Hinrichs, Jan B., Meyer, Bernhard C.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Basel MDPI AG 26.08.2021 MDPI
Predmet:	Abdomen Clinical medicine Iodine Liver cancer Patients Radiation therapy Scanners Sensors Tomography Tumors Veins & arteries United States > US Germany Chicago Illinois
ISSN:	2077-0383, 2077-0383
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	(1) Background: To comparatively analyze the uptake of hepatocellular carcinoma (HCC) on pre-therapeutic imaging modalities, the arterial phase multi-detector computed tomography (MDCT), the parenchymal phase C-arm computed tomography (CACT), the Technetium99m-macroaggregates of human serum albumin single-photon emission computed tomography/computed tomography (SPECT/CT), and the correlation to the post-therapeutic Yttrium90 positron emission tomography/computed tomography (PET/CT) in patients with selective internal radiation therapy (SIRT). (2) Methods: Between September 2013 and December 2016, 104 SIRT procedures were performed at our institution in 74 patients with HCC not suitable for curative surgery or ablation. Twenty-two patients underwent an identical sequence of pre-therapeutic MDCT, CACT, SPECT/CT, and post-therapeutic PET/CT with a standardized diagnostic and therapeutic protocol. In these 22 patients, 25 SIRT procedures were evaluated. The uptake of the HCC was assessed using tumor-background ratio (TBR). Therefore, regions of interest were placed on the tumor and the adjacent liver tissue on MDCT (TBRMDCT), CACT (TBRCACT), SPECT/CT (TBRSPECT/CT), and PET/CT (TBRPET/CT). Comparisons were made with the Friedman test and the Nemenyi post-hoc test. Correlations were analyzed using Spearman’s Rho and the Benjamini–Hochberg method. The level of significance was p < 0.05. (3) Results: TBR on MDCT (1.4 ± 0.3) was significantly smaller than on CACT (1.9 ± 0.6) and both were significantly smaller compared to SPECT/CT (4.6 ± 2.0) (pFriedman-Test < 0.001; pTBRMDCT/TBRCACT = 0.012, pTBRMDCT/TBRSPECT/CT < 0.001, pTBRCACT/TBRSPECT/CT < 0.001). There was no significant correlation of TBR on MDCT with PET/CT (rTBRMDCT/TBRPET/CT = 0.116; p = 0.534). In contrast, TBR on CACT correlated to TBR on SPECT/CT (rTBRCACT/TBRSPECT/CT = 0.489; p = 0.004) and tended to correlate to TBR on PET/CT (rTBRCACT/TBRPET/CT =0.365; p = 0.043). TBR on SPECT/CT correlated to TBR on PET/CT (rTBRSPECT/CT/TBRPET/CT = 0.706; p < 0.001) (4) Conclusion: The uptake assessment on CACT was in agreement with SPECT/CT and might be consistent with PET/CT. In contrast, MDCT was not comparable to CACT and SPECT/CT, and had no correlation with PET/CT due to the different application techniques. This emphasizes the value of the CACT, which has the potential to improve the dosimetric assessment of the tumor and liver uptake for SIRT.
AbstractList	(1) Background: To comparatively analyze the uptake of hepatocellular carcinoma (HCC) on pre-therapeutic imaging modalities, the arterial phase multi-detector computed tomography (MDCT), the parenchymal phase C-arm computed tomography (CACT), the Technetium99m-macroaggregates of human serum albumin single-photon emission computed tomography/computed tomography (SPECT/CT), and the correlation to the post-therapeutic Yttrium90 positron emission tomography/computed tomography (PET/CT) in patients with selective internal radiation therapy (SIRT). (2) Methods: Between September 2013 and December 2016, 104 SIRT procedures were performed at our institution in 74 patients with HCC not suitable for curative surgery or ablation. Twenty-two patients underwent an identical sequence of pre-therapeutic MDCT, CACT, SPECT/CT, and post-therapeutic PET/CT with a standardized diagnostic and therapeutic protocol. In these 22 patients, 25 SIRT procedures were evaluated. The uptake of the HCC was assessed using tumor-background ratio (TBR). Therefore, regions of interest were placed on the tumor and the adjacent liver tissue on MDCT (TBRMDCT), CACT (TBRCACT), SPECT/CT (TBRSPECT/CT), and PET/CT (TBRPET/CT). Comparisons were made with the Friedman test and the Nemenyi post-hoc test. Correlations were analyzed using Spearman's Rho and the Benjamini-Hochberg method. The level of significance was p < 0.05. (3) Results: TBR on MDCT (1.4 ± 0.3) was significantly smaller than on CACT (1.9 ± 0.6) and both were significantly smaller compared to SPECT/CT (4.6 ± 2.0) (pFriedman-Test < 0.001; pTBRMDCT/TBRCACT = 0.012, pTBRMDCT/TBRSPECT/CT < 0.001, pTBRCACT/TBRSPECT/CT < 0.001). There was no significant correlation of TBR on MDCT with PET/CT (rTBRMDCT/TBRPET/CT = 0.116; p = 0.534). In contrast, TBR on CACT correlated to TBR on SPECT/CT (rTBRCACT/TBRSPECT/CT = 0.489; p = 0.004) and tended to correlate to TBR on PET/CT (rTBRCACT/TBRPET/CT =0.365; p = 0.043). TBR on SPECT/CT correlated to TBR on PET/CT (rTBRSPECT/CT/TBRPET/CT = 0.706; p < 0.001) (4) Conclusion: The uptake assessment on CACT was in agreement with SPECT/CT and might be consistent with PET/CT. In contrast, MDCT was not comparable to CACT and SPECT/CT, and had no correlation with PET/CT due to the different application techniques. This emphasizes the value of the CACT, which has the potential to improve the dosimetric assessment of the tumor and liver uptake for SIRT.(1) Background: To comparatively analyze the uptake of hepatocellular carcinoma (HCC) on pre-therapeutic imaging modalities, the arterial phase multi-detector computed tomography (MDCT), the parenchymal phase C-arm computed tomography (CACT), the Technetium99m-macroaggregates of human serum albumin single-photon emission computed tomography/computed tomography (SPECT/CT), and the correlation to the post-therapeutic Yttrium90 positron emission tomography/computed tomography (PET/CT) in patients with selective internal radiation therapy (SIRT). (2) Methods: Between September 2013 and December 2016, 104 SIRT procedures were performed at our institution in 74 patients with HCC not suitable for curative surgery or ablation. Twenty-two patients underwent an identical sequence of pre-therapeutic MDCT, CACT, SPECT/CT, and post-therapeutic PET/CT with a standardized diagnostic and therapeutic protocol. In these 22 patients, 25 SIRT procedures were evaluated. The uptake of the HCC was assessed using tumor-background ratio (TBR). Therefore, regions of interest were placed on the tumor and the adjacent liver tissue on MDCT (TBRMDCT), CACT (TBRCACT), SPECT/CT (TBRSPECT/CT), and PET/CT (TBRPET/CT). Comparisons were made with the Friedman test and the Nemenyi post-hoc test. Correlations were analyzed using Spearman's Rho and the Benjamini-Hochberg method. The level of significance was p < 0.05. (3) Results: TBR on MDCT (1.4 ± 0.3) was significantly smaller than on CACT (1.9 ± 0.6) and both were significantly smaller compared to SPECT/CT (4.6 ± 2.0) (pFriedman-Test < 0.001; pTBRMDCT/TBRCACT = 0.012, pTBRMDCT/TBRSPECT/CT < 0.001, pTBRCACT/TBRSPECT/CT < 0.001). There was no significant correlation of TBR on MDCT with PET/CT (rTBRMDCT/TBRPET/CT = 0.116; p = 0.534). In contrast, TBR on CACT correlated to TBR on SPECT/CT (rTBRCACT/TBRSPECT/CT = 0.489; p = 0.004) and tended to correlate to TBR on PET/CT (rTBRCACT/TBRPET/CT =0.365; p = 0.043). TBR on SPECT/CT correlated to TBR on PET/CT (rTBRSPECT/CT/TBRPET/CT = 0.706; p < 0.001) (4) Conclusion: The uptake assessment on CACT was in agreement with SPECT/CT and might be consistent with PET/CT. In contrast, MDCT was not comparable to CACT and SPECT/CT, and had no correlation with PET/CT due to the different application techniques. This emphasizes the value of the CACT, which has the potential to improve the dosimetric assessment of the tumor and liver uptake for SIRT. (1) Background: To comparatively analyze the uptake of hepatocellular carcinoma (HCC) on pre-therapeutic imaging modalities, the arterial phase multi-detector computed tomography (MDCT), the parenchymal phase C-arm computed tomography (CACT), the Technetium99m-macroaggregates of human serum albumin single-photon emission computed tomography/computed tomography (SPECT/CT), and the correlation to the post-therapeutic Yttrium90 positron emission tomography/computed tomography (PET/CT) in patients with selective internal radiation therapy (SIRT). (2) Methods: Between September 2013 and December 2016, 104 SIRT procedures were performed at our institution in 74 patients with HCC not suitable for curative surgery or ablation. Twenty-two patients underwent an identical sequence of pre-therapeutic MDCT, CACT, SPECT/CT, and post-therapeutic PET/CT with a standardized diagnostic and therapeutic protocol. In these 22 patients, 25 SIRT procedures were evaluated. The uptake of the HCC was assessed using tumor-background ratio (TBR). Therefore, regions of interest were placed on the tumor and the adjacent liver tissue on MDCT (TBRMDCT), CACT (TBRCACT), SPECT/CT (TBRSPECT/CT), and PET/CT (TBRPET/CT). Comparisons were made with the Friedman test and the Nemenyi post-hoc test. Correlations were analyzed using Spearman’s Rho and the Benjamini–Hochberg method. The level of significance was p < 0.05. (3) Results: TBR on MDCT (1.4 ± 0.3) was significantly smaller than on CACT (1.9 ± 0.6) and both were significantly smaller compared to SPECT/CT (4.6 ± 2.0) (pFriedman-Test < 0.001; pTBRMDCT/TBRCACT = 0.012, pTBRMDCT/TBRSPECT/CT < 0.001, pTBRCACT/TBRSPECT/CT < 0.001). There was no significant correlation of TBR on MDCT with PET/CT (rTBRMDCT/TBRPET/CT = 0.116; p = 0.534). In contrast, TBR on CACT correlated to TBR on SPECT/CT (rTBRCACT/TBRSPECT/CT = 0.489; p = 0.004) and tended to correlate to TBR on PET/CT (rTBRCACT/TBRPET/CT =0.365; p = 0.043). TBR on SPECT/CT correlated to TBR on PET/CT (rTBRSPECT/CT/TBRPET/CT = 0.706; p < 0.001) (4) Conclusion: The uptake assessment on CACT was in agreement with SPECT/CT and might be consistent with PET/CT. In contrast, MDCT was not comparable to CACT and SPECT/CT, and had no correlation with PET/CT due to the different application techniques. This emphasizes the value of the CACT, which has the potential to improve the dosimetric assessment of the tumor and liver uptake for SIRT.
Author	Becker, Lena S. Hinrichs, Jan B. Kirstein, Martha M. Werncke, Thomas Schütze, Christian Meyer, Bernhard C. Meine, Timo C. Dewald, Cornelia L. A. Kretschmann, Nils Wacker, Frank K. Maschke, Sabine K. Brunkhorst, Thomas Vogel, Arndt
AuthorAffiliation	4 Department of Radiation Protection and Medical Physics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany 5 Department of Hepatology, Gastroenterology and Endocrinology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany; vogel.arndt@mh-hannover.de 3 Department of Nuclear Medicine, University Medical Center Goettingen, Robert-Koch-Straße 40, 37075 Goettingen, Germany; christian.schütze@med.uni-goettingen.de 6 1st Department of Medicine, University Medical Center Schleswig-Holstein Luebeck Campus, Ratzeburger Allee 160, 23562 Luebeck, Germany; martha.kirstein@uksh.de 1 Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany; meine.timo@mh-hannover.de (T.C.M.); werncke.thomas@mh-hannover.de (T.W.); dewald.cornelia@mh-hannover.de (C.L.A.D.); becker.lena@mh-hannover.de (L.S.B.); maschke.sabine@mh-hannover.de (S.K.M.); nils.kretschman@stud.mh-hannover.de (N.K.); wacker.frank@mh-ha
AuthorAffiliation_xml	– name: 5 Department of Hepatology, Gastroenterology and Endocrinology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany; vogel.arndt@mh-hannover.de – name: 1 Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany; meine.timo@mh-hannover.de (T.C.M.); werncke.thomas@mh-hannover.de (T.W.); dewald.cornelia@mh-hannover.de (C.L.A.D.); becker.lena@mh-hannover.de (L.S.B.); maschke.sabine@mh-hannover.de (S.K.M.); nils.kretschman@stud.mh-hannover.de (N.K.); wacker.frank@mh-hannover.de (F.K.W.); meyer.bernhard@mh-hannover.de (B.C.M.) – name: 3 Department of Nuclear Medicine, University Medical Center Goettingen, Robert-Koch-Straße 40, 37075 Goettingen, Germany; christian.schütze@med.uni-goettingen.de – name: 6 1st Department of Medicine, University Medical Center Schleswig-Holstein Luebeck Campus, Ratzeburger Allee 160, 23562 Luebeck, Germany; martha.kirstein@uksh.de – name: 4 Department of Radiation Protection and Medical Physics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany – name: 2 Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany; brunkhorst.thomas@mh-hannover.de
Author_xml	– sequence: 1 givenname: Timo C. surname: Meine fullname: Meine, Timo C. – sequence: 2 givenname: Thomas surname: Brunkhorst fullname: Brunkhorst, Thomas – sequence: 3 givenname: Thomas surname: Werncke fullname: Werncke, Thomas – sequence: 4 givenname: Christian surname: Schütze fullname: Schütze, Christian – sequence: 5 givenname: Arndt orcidid: 0000-0003-0560-5538 surname: Vogel fullname: Vogel, Arndt – sequence: 6 givenname: Martha M. surname: Kirstein fullname: Kirstein, Martha M. – sequence: 7 givenname: Cornelia L. A. surname: Dewald fullname: Dewald, Cornelia L. A. – sequence: 8 givenname: Lena S. surname: Becker fullname: Becker, Lena S. – sequence: 9 givenname: Sabine K. surname: Maschke fullname: Maschke, Sabine K. – sequence: 10 givenname: Nils surname: Kretschmann fullname: Kretschmann, Nils – sequence: 11 givenname: Frank K. surname: Wacker fullname: Wacker, Frank K. – sequence: 12 givenname: Jan B. surname: Hinrichs fullname: Hinrichs, Jan B. – sequence: 13 givenname: Bernhard C. orcidid: 0000-0003-0278-5481 surname: Meyer fullname: Meyer, Bernhard C.
BookMark	eNptksFu1DAQhi1URMvSEy9giQsShNpxdpNckKqwtJWKWNHdczRxJrteEju1naK-JM-E07RVW-GDx2N_82v822_JgTYaCXnP2Rchcnaylx1nPBWZSF-Ro5ilacRCcvBkfUiOnduzMLIsiXn6hhyKZM54nCVH5G9huh6sckZT01C_Q7rpPfzGMTvHHryR2LZDC5YWYKXSpgMa4JXFaL1DCz0OXkn641ux_kyL03EGXdOr1bJYnzxko25hrMUWvArVf5Tf0ZVx_pnGajlWUBXUA4baO7rRNdqtUXpLr7BF6dUN0gvt0Wpo6S-o1SQ4ydy-I68baB0e38cZ2Xxfrovz6PLn2UVxehlJkS18lMRCBg-gyYJJeYU5m_M8S6qmwqqGBMN-1aSccxAoWVPnuUhYCguQDHjNUMzI10m3H6oOaxl6tdCWvVUd2NvSgCqfn2i1K7fmpswSEY-PMiMf7wWsuR7Q-bJTbnQaNJrBlfE85XnMQwjohxfo3gzj9SdK8JQtRKA-TZS0xjmLzWMznJXjVymffJVA8xe0VP7OydCtav9b8w_EvsQC
CitedBy_id	crossref_primary_10_3390_jcm11237245
Cites_doi	10.1088/2057-1976/ab36c2 10.1016/S1470-2045(17)30683-6 10.1007/s00330-015-4203-4 10.1007/s00270-019-02198-6 10.1186/s40658-017-0192-5 10.1055/s-0030-1247133 10.1007/s00330-006-0508-7 10.2214/AJR.07.2695 10.1016/j.acra.2011.12.015 10.1055/s-0030-1247132 10.1053/j.tvir.2019.02.011 10.1118/1.4725711 10.1007/s00270-018-2030-0 10.1186/s13550-019-0533-6 10.1016/j.diii.2020.09.003 10.1016/j.jhep.2019.08.006 10.1186/s13550-019-0485-x 10.1007/s00270-015-1180-6 10.1016/j.jvir.2013.11.005 10.2967/jnumed.115.162685 10.1200/JCO.2017.76.0892 10.2967/jnumed.115.169987 10.1007/s00259-016-3438-x 10.1007/s00259-013-2395-x
ContentType	Journal Article
Copyright	2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2021 by the authors. 2021
Copyright_xml	– notice: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2021 by the authors. 2021
DBID	AAYXX CITATION 3V. 7X7 7XB 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 5PM
DOI	10.3390/jcm10173837
DatabaseName	CrossRef ProQuest Central (Corporate) ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Local Electronic Collection Information ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest One Academic Eastern Edition ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest One Health & Nursing ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central ProQuest Health & Medical Complete ProQuest Health & Medical Research Collection Health Research Premium Collection ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Central (New) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic Publicly Available Content Database CrossRef
Database_xml	– sequence: 1 dbid: PIMPY name: ProQuest Publicly Available Content url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	2077-0383
ExternalDocumentID	PMC8432038 10_3390_jcm10173837
GeographicLocations	United States--US Germany Chicago Illinois
GeographicLocations_xml	– name: United States--US – name: Germany – name: Chicago Illinois
GroupedDBID	53G 5VS 7X7 8FI 8FJ AADQD AAFWJ AAYXX ABDBF ABUWG ACUHS ADBBV AFFHD AFKRA AFZYC ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV BENPR CCPQU CITATION DIK FYUFA HMCUK HYE IAO IHR ITC KQ8 M48 MODMG M~E OK1 PGMZT PHGZM PHGZT PIMPY RPM UKHRP 3V. 7XB 8FK AZQEC DWQXO K9. PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 PUEGO 5PM
ID	FETCH-LOGICAL-c386t-423c345af80779be9051984bfbebda4ef80bf7111a3ec0fd993407a6ac0a1d0e3
IEDL.DBID	BENPR
ISICitedReferencesCount	1
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000694392600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	2077-0383
IngestDate	Tue Nov 04 02:03:05 EST 2025 Thu Sep 04 16:32:46 EDT 2025 Tue Oct 07 07:09:41 EDT 2025 Tue Nov 18 22:13:00 EST 2025 Sat Nov 29 07:14:17 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	17
Language	English
License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c386t-423c345af80779be9051984bfbebda4ef80bf7111a3ec0fd993407a6ac0a1d0e3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Both Authors Contributed Equally to This Work.
ORCID	0000-0003-0278-5481 0000-0003-0560-5538
OpenAccessLink	https://www.proquest.com/docview/2571317063?pq-origsite=%requestingapplication%
PMID	34501284
PQID	2571317063
PQPubID	5046890
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_8432038 proquest_miscellaneous_2571921257 proquest_journals_2571317063 crossref_primary_10_3390_jcm10173837 crossref_citationtrail_10_3390_jcm10173837
PublicationCentury	2000
PublicationDate	20210826
PublicationDateYYYYMMDD	2021-08-26
PublicationDate_xml	– month: 8 year: 2021 text: 20210826 day: 26
PublicationDecade	2020
PublicationPlace	Basel
PublicationPlace_xml	– name: Basel
PublicationTitle	Journal of clinical medicine
PublicationYear	2021
Publisher	MDPI AG MDPI
Publisher_xml	– name: MDPI AG – name: MDPI
References	Gates (ref_24) 2014; 25 Spahr (ref_13) 2017; 4 Martin (ref_20) 2021; 102 Toskich (ref_7) 2019; 22 Jones (ref_14) 2012; 39 Grosser (ref_8) 2016; 57 Coudyzer (ref_11) 2019; 9 Meyer (ref_15) 2008; 190 Kafrouni (ref_18) 2019; 9 Bapst (ref_21) 2016; 39 Reiner (ref_12) 2012; 19 Ricke (ref_5) 2019; 71 Pasik (ref_10) 2020; 43 Gabr (ref_25) 2016; 43 Vilgrain (ref_4) 2017; 18 Jiang (ref_23) 2011; 26 Ilhan (ref_17) 2015; 56 Hinrichs (ref_19) 2016; 26 Garin (ref_6) 2013; 40 Jakobs (ref_1) 2007; 17 Forner (ref_2) 2010; 30 Henry (ref_22) 2019; 5 Ertreo (ref_9) 2018; 41 Chow (ref_3) 2018; 36 Lencioni (ref_16) 2010; 30
References_xml	– volume: 5 start-page: 055011 year: 2019 ident: ref_22 article-title: Quantification of the inherent radiopacity of glass microspheres for precision dosimetry in yttrium-90 radioembolization publication-title: Biomed. Phys. Eng. Express. doi: 10.1088/2057-1976/ab36c2 – volume: 18 start-page: 1624 year: 2017 ident: ref_4 article-title: Efficacy and safety of selective internal radiotherapy with yttrium-90 resin microspheres compared with sorafenib in locally advanced and inoperable hepatocellular carcinoma (SARAH): An open-label randomised controlled phase 3 trial publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(17)30683-6 – volume: 26 start-page: 3447 year: 2016 ident: ref_19 article-title: Parametric response mapping of contrast-enhanced biphasic CT for evaluating tumour viability of hepatocellular carcinoma after TACE publication-title: Eur. Radiol. doi: 10.1007/s00330-015-4203-4 – volume: 43 start-page: 295 year: 2020 ident: ref_10 article-title: Feasibility of Yttrium-90 Radioembolization Dose Calculation Utilizing Intra-procedural Open Trajectory Cone Beam CT publication-title: Cardiovasc. Intervent. Radiol. doi: 10.1007/s00270-019-02198-6 – volume: 4 start-page: 25 year: 2017 ident: ref_13 article-title: Predictive SIRT dosimetry based on a territorial model publication-title: EJNMMI Phys. doi: 10.1186/s40658-017-0192-5 – volume: 30 start-page: 61 year: 2010 ident: ref_2 article-title: Current Strategy for Staging and Treatment: The BCLC Update and Future Prospects publication-title: Semin. Liver Dis. doi: 10.1055/s-0030-1247133 – volume: 17 start-page: 1320 year: 2007 ident: ref_1 article-title: Mid-term results in otherwise treatment refractory primary or secondary liver confined tumours treated with selective internal radiation therapy (SIRT) using 90Yttrium resin-microspheres publication-title: Eur. Radiol. doi: 10.1007/s00330-006-0508-7 – volume: 190 start-page: W263 year: 2008 ident: ref_15 article-title: Visualization of Hypervascular Liver Lesions During TACE: Comparison of Angiographic C-Arm CT and MDCT publication-title: Am. J. Roentgenol. doi: 10.2214/AJR.07.2695 – volume: 19 start-page: 613 year: 2012 ident: ref_12 article-title: Liver Perfusion Imaging in Patients with Primary and Metastatic Liver Malignancy publication-title: Acad. Radiol. doi: 10.1016/j.acra.2011.12.015 – volume: 30 start-page: 52 year: 2010 ident: ref_16 article-title: Modified RECIST (mRECIST) Assessment for Hepatocellular Carcinoma publication-title: Semin. Liver Dis. doi: 10.1055/s-0030-1247132 – volume: 22 start-page: 100 year: 2019 ident: ref_7 article-title: Y90 Radioembolization Dosimetry: Concepts for the Interventional Radiologist publication-title: Tec. Vas. Interv. Radiol. doi: 10.1053/j.tvir.2019.02.011 – volume: 39 start-page: 4149 year: 2012 ident: ref_14 article-title: Evaluation of the potential utility of flat panel CT for quantifying relative contrast enhancement: Potential utility of FPCT for quantifying relative enhancement publication-title: Med Phys. doi: 10.1118/1.4725711 – volume: 41 start-page: 1857 year: 2018 ident: ref_9 article-title: Comparison of Cone-Beam Tomography and Cross-Sectional Imaging for Volumetric and Dosimetric Calculations in Resin Yttrium-90 Radioembolization publication-title: Cardiovasc. Intervent. Radiol. doi: 10.1007/s00270-018-2030-0 – volume: 9 start-page: 62 year: 2019 ident: ref_18 article-title: Analysis of differences between 99mTc-MAA SPECT- and 90Y-microsphere PET-based dosimetry for hepatocellular carcinoma selective internal radiation therapy publication-title: EJNMMI Res. doi: 10.1186/s13550-019-0533-6 – volume: 102 start-page: 45 year: 2021 ident: ref_20 article-title: Comparison of perfused volume segmentation between cone-beam CT and 99mTc-MAA SPECT/CT for treatment dosimetry before selective internal radiation therapy using 90Y-glass microspheres publication-title: Diagn. Interv. Imaging doi: 10.1016/j.diii.2020.09.003 – volume: 71 start-page: 1164 year: 2019 ident: ref_5 article-title: Impact of combined selective internal radiation therapy and sorafenib on survival in advanced hepatocellular carcinoma publication-title: J. Hepatol. doi: 10.1016/j.jhep.2019.08.006 – volume: 9 start-page: 19 year: 2019 ident: ref_11 article-title: Multi-modal image analysis for semi-automatic segmentation of the total liver and liver arterial perfusion territories for radioembolization publication-title: EJNMMI Res. doi: 10.1186/s13550-019-0485-x – volume: 39 start-page: 8 year: 2016 ident: ref_21 article-title: Cone Beam Computed Tomography (CBCT) in the Field of Interventional Oncology of the Liver publication-title: Cardiovasc. Intervent. Radiol. doi: 10.1007/s00270-015-1180-6 – volume: 25 start-page: 266 year: 2014 ident: ref_24 article-title: Outpatient Single-Session Yttrium-90 Glass Microsphere Radioembolization publication-title: J. Vas. Interv. Radiol. doi: 10.1016/j.jvir.2013.11.005 – volume: 56 start-page: 1654 year: 2015 ident: ref_17 article-title: Predictive Value of 99mTc-MAA SPECT for 90Y-Labeled Resin Microsphere Distribution in Radioembolization of Primary and Secondary Hepatic Tumors publication-title: J. Nucl. Med. doi: 10.2967/jnumed.115.162685 – volume: 26 start-page: 511 year: 2011 ident: ref_23 article-title: Characterization of Extrahepatic Distribution of Tc-99m Macroaggregated Albumin in Hepatic Perfusion Imaging Studies Prior to Yttrium-90 Microsphere Therapy publication-title: Cancer Biother. Radiopharm. – volume: 36 start-page: 1913 year: 2018 ident: ref_3 article-title: SIRveNIB: Selective Internal Radiation Therapy Versus Sorafenib in Asia-Pacific Patients With Hepatocellular Carcinoma publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2017.76.0892 – volume: 57 start-page: 925 year: 2016 ident: ref_8 article-title: Pharmacokinetics of 99mTc-MAA- and 99mTc-HSA-Microspheres Used in Preradioembolization Dosimetry: Influence on the Liver-Lung Shunt publication-title: J. Nucl. Med. doi: 10.2967/jnumed.115.169987 – volume: 43 start-page: 2353 year: 2016 ident: ref_25 article-title: Same-day 90Y radioembolization: Implementing a new treatment paradigm publication-title: Eur. J. Nucl. Med. Mol. Imaging doi: 10.1007/s00259-016-3438-x – volume: 40 start-page: 1057 year: 2013 ident: ref_6 article-title: Boosted selective internal radiation therapy with 90Y-loaded glass microspheres (B-SIRT) for hepatocellular carcinoma patients: A new personalized promising concept publication-title: Eur. J. Nucl. Med. Mol. Imaging doi: 10.1007/s00259-013-2395-x
SSID	ssj0000884217
Score	2.1770775
Snippet	(1) Background: To comparatively analyze the uptake of hepatocellular carcinoma (HCC) on pre-therapeutic imaging modalities, the arterial phase multi-detector...
SourceID	pubmedcentral proquest crossref
SourceType	Open Access Repository Aggregation Database Enrichment Source Index Database
StartPage	3837
SubjectTerms	Abdomen Clinical medicine Iodine Liver cancer Patients Radiation therapy Scanners Sensors Tomography Tumors Veins & arteries
Title	Comparison of the Uptake of Hepatocellular Carcinoma on Pre-Therapeutic MDCT, CACT, and SPECT/CT, and the Correlation with Post-Therapeutic PET/CT in Patients Undergoing Selective Internal Radiation Therapy
URI	https://www.proquest.com/docview/2571317063 https://www.proquest.com/docview/2571921257 https://pubmed.ncbi.nlm.nih.gov/PMC8432038
Volume	10
WOSCitedRecordID	wos000694392600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2077-0383 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000884217 issn: 2077-0383 databaseCode: M~E dateStart: 20120101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2077-0383 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000884217 issn: 2077-0383 databaseCode: BENPR dateStart: 20190101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Health & Medical Collection customDbUrl: eissn: 2077-0383 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000884217 issn: 2077-0383 databaseCode: 7X7 dateStart: 20190101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Publicly Available Content customDbUrl: eissn: 2077-0383 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000884217 issn: 2077-0383 databaseCode: PIMPY dateStart: 20190101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3fb9MwELZYh9Be-I1WGJOR9oSImsVu4jyhETKNh1bR1knlKbIdexS2pLQZEi_8ifxN3CVuukiIF14iOXHOke58Pp8v30fIEWfMCMUCzwZGe9xa68VahoiMCOr2ZayZbcgmoulUzOdx5hJua1dWufGJjaMuKo058hGY1jFDrBf2fvndQ9YoPF11FBo7ZBeRyviA7H5Ip9l5l2WBOcQh6G5_zGOwvx991Tdohbgx6y9F2_iyXx15Z7k5ffS_H_qYPHSBJj1pLeMJuWfKp-TBxB2lPyO_k46BkFaWQhxIL5e1_GawdQaLVF1hUh-rVGmChENldSMpdM5Wxptt_9qik4_J7B1NTvAqy4JeZGkyG21aKDdBBpC25o5i3pciQ3BPRpbiG3QB0luc1zVtCJmuKlhZ6UXD1QNumbr85TU9R0iFRmAr5udzcnmazpIzz5E7eJqJsPYgjNOMj6UVfhTFyiBOWCy4ssqoQnID95WNwBNLZrRvC4ijYO8pQ6l9eVz4hr0gg7IqzT6hJuCh8lUoheXc-CzWIlQSvBODAMSMgyF5u9Fzrh3yORJwXOewA0KjyO8YxZAcdZ2XLeDH37sdbLSfu1m_zreqH5I33WOYr6gvWZrqtu0TQ7wwBhFRz9C64RDxu_-kXHxpkL8FZ4HPxMt_D_6K7AVYeeODDwwPyKBe3ZrX5L7-US_Wq0OyE82j5ioO3XSB1uRXCq3s0yT7_AcNXSTj
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELbKFgEX3oiFAkYqF0S0buzN44BQlW61q3ZXEU2lckodx4aFNll2U1D_FD-F38RMXttIiFsPXCIlccZS_GVm7Iy_j5Btwbn2Em5bxtbKEsYYy1fSQWZEGG4mfcVNKTbhzmbeyYkfbpBfzV4YLKtsfGLpqNNc4Rr5AKC1w5HrhX9YfLdQNQr_rjYSGhUsDvTlT5iyrd5P9mB839j2_igKxlatKmAp7jmFBfmD4mIojcdc1080ElT5nkhMopNUCg3XE-OCC5BcK2ZSCOAw6ZGOVEzupExzsHuDbAoAu9cjm-FkGn5qV3XgmxWQ5FcbATn32eCrOkfU40SwG_rW-Wy3GvNKeNu_97-9mPvkbp1I090K-Q_Ihs4eklvTulTgEfkdtAqLNDcU8lx6vCjkN41nYwjCRY4_LbAKlwYoqJTl55JC43CprWi9K41O94LoHQ128SizlB6FoyAaNGdoN0CFk6qmkOK6NkUF5I6NcIRP0DlYr3hsV7QUnPqcQ-ZAj0otIgg7tF6fPaMfkTKiNFiZuXxMjq_lbT4hvSzP9FNCtS2chCWO9IwQmnFfeU4iwftySLD00O6Ttw2uYlUzu6PAyFkMMzwEYXwFhH2y3TZeVIQmf2-21aAtrr3aKl5DrU9et7fBH-F4yUznF1UbH_KhIZhwO8Buu0NG8-6dbP6lZDb3BLcZ9579u_NX5PY4mh7Gh5PZwXNyx8YqIwb-3tkivWJ5oV-Qm-pHMV8tX9afJyWn1w38Py8rfow
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLbGhqa9cEeUXTDSeEFE9WI3lweEprTVqtEqYp00noLj2KywJV2bgfbX-BH8Js7JrYuEeNsDL5ESOyeS_Z2LnePzEbIvONdezG3L2FpZwhhj-Uo6WBkRpptJX3FTkE24k4l3duaHa-RXfRYG0yprm1gY6iRTuEfeBWgdcKz1wrumSosI-8MP8ysLGaTwT2tNp1FC5Fjf_ITl2_L9qA9z_ca2h4NpcGRVDAOW4p6TWxBLKC560njMdf1YY7Eq3xOxiXWcSKHheWxcMAeSa8VMAs4cFkDSkYrJg4RpDnLvkQ0IyQXo2EY4Goefmx0e0F8BAX95KJBzn3W_qUvUAFwUtt3gKrZtZ2becnXDh__zID0iD6oAmx6WGvGYrOn0CdkcVykET8nvoGFepJmhEP_S03kuv2u8OwLnnGf4MwOzc2mAREtpdikpdA4X2pquTqvRcT-YvqPBIV5lmtCTcBBMu_Udyg2Q-aTMNaS4302RGbklIxzgG3QG0sv6tktaEFF9zSCioCcFRxG4I1rt217QT1hKohBYirl5Rk7vZDSfk_U0S_ULQrUtnJjFjvSMEJpxX3lOLMEqcwi8dM_ukLc1xiJVVXxH4pGLCFZ-CMjoFiA7ZL_pPC8Lnfy9206NvKiydstoBbsOed00g53C-ZKpzq7LPj7EST0Q4bZA3nwOK523W9LZeVHx3BPcZtx7-e-PvyKbgPbo42hyvE22bEw-YuAGnB2yni-u9S65r37ks-Vir9JUSr7cNe7_ACUth0w
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Comparison+of+the+Uptake+of+Hepatocellular+Carcinoma+on+Pre-Therapeutic+MDCT%2C+CACT%2C+and+SPECT%2FCT%2C+and+the+Correlation+with+Post-Therapeutic+PET%2FCT+in+Patients+Undergoing+Selective+Internal+Radiation+Therapy&rft.jtitle=Journal+of+clinical+medicine&rft.au=Meine%2C+Timo+C.&rft.au=Brunkhorst%2C+Thomas&rft.au=Werncke%2C+Thomas&rft.au=Sch%C3%BCtze%2C+Christian&rft.date=2021-08-26&rft.issn=2077-0383&rft.eissn=2077-0383&rft.volume=10&rft.issue=17&rft.spage=3837&rft_id=info:doi/10.3390%2Fjcm10173837&rft.externalDBID=n%2Fa&rft.externalDocID=10_3390_jcm10173837
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2077-0383&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2077-0383&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2077-0383&client=summon