Polyphenol (−)-Epigallocatechin Gallate (EGCG) mitigated kidney injury by regulating metabolic homeostasis and mitochondrial dynamics involvement with Drp1-mediated mitochondrial fission in mice

The study aimed to examine effects of (−)-epigallocatechin-3-gallate (EGCG) on energy metabolism and mitochondrial dynamics in mouse model of renal injury caused by doxorubicin (DOX). Here, mice were divided into Control group, EGCG-only treated group, DOX group, and three doses of EGCG plus DOX gro...

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Bibliographic Details
Published in:	Food and chemical toxicology Vol. 191; p. 114906
Main Authors:	Chu, Yue-Lei, Pi, Jin-Chan, Yao, Yu-Fei, Chen, Xuan-Ying, Peng, Xiao-Ping, Li, Wen-Juan
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.09.2024
Subjects:	(−)-Epigallocatechin gallate Acute Kidney Injury - chemically induced Acute Kidney Injury - drug therapy Acute Kidney Injury - metabolism Acute Kidney Injury - prevention & control Animals Antioxidants - pharmacology apoptosis Apoptosis - drug effects blood serum Catechin - analogs & derivatives Catechin - pharmacology creatinine doxorubicin Doxorubicin - toxicity Dynamins - metabolism Energy metabolism Energy Metabolism - drug effects epigallocatechin gallate glycolysis hexokinase homeostasis Homeostasis - drug effects Kidney - drug effects Kidney - metabolism Kidney injury kidneys malate dehydrogenase Male malondialdehyde membrane potential Membrane Potential, Mitochondrial - drug effects Mice mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondrial dynamics Mitochondrial Dynamics - drug effects mitochondrial membrane oxidative phosphorylation Oxidative stress Oxidative Stress - drug effects polyphenols protective effect reactive oxygen species Reactive Oxygen Species - metabolism renoprotective effect toxicology urea nitrogen Oxidative stress Energy metabolism GSH-PX HK SCr Mitochondrial dynamics EGCG SOD (−)-Epigallocatechin gallate MDA DOX Drp1 MDH DCFH-DA ΔΨm Rhodamine 123 CAT ROS BUN Kidney injury
ISSN:	0278-6915, 1873-6351, 1873-6351
Online Access:	Get full text
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