Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056

Fragile X syndrome (FXS) is an X-linked condition associated with intellectual disability and behavioral problems. It is caused by expansion of a CGG repeat in the 5' untranslated region of the fragile X mental retardation 1 (FMR1) gene. This mutation is associated with hypermethylation at the...

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Vydáno v:	Science translational medicine Ročník 3; číslo 64; s. 64ra1
Hlavní autoři:	Jacquemont, Sébastien, Curie, Aurore, des Portes, Vincent, Torrioli, Maria Giulia, Berry-Kravis, Elizabeth, Hagerman, Randi J, Ramos, Feliciano J, Cornish, Kim, He, Yunsheng, Paulding, Charles, Neri, Giovanni, Chen, Fei, Hadjikhani, Nouchine, Martinet, Danielle, Meyer, Joanne, Beckmann, Jacques S, Delange, Karine, Brun, Amandine, Bussy, Gerald, Gasparini, Fabrizio, Hilse, Talita, Floesser, Annette, Branson, Janice, Bilbe, Graeme, Johns, Donald, Gomez-Mancilla, Baltazar
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 05.01.2011
Témata:	Adult DNA Methylation - genetics Epigenesis, Genetic - genetics Fragile X Mental Retardation Protein - genetics Fragile X Syndrome - drug therapy Fragile X Syndrome - genetics Humans Male Middle Aged Promoter Regions, Genetic - genetics Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate - antagonists & inhibitors Young Adult
ISSN:	1946-6242, 1946-6242
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