Lack of reproducibility of histopathological features in MYC‐rearranged large B cell lymphoma using digital whole slide images: a study from the Lunenburg lymphoma biomarker consortium

Aims Subclassification of large B cell lymphoma (LBCL) is challenging due to the overlap in histopathological, immunophenotypical and genetic data. In particular, the criteria to separate diffuse large B cell lymphoma (DLBCL) and high‐grade B cell lymphoma (HGBL) are difficult to apply in practice....

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Bibliographic Details
Published in:	Histopathology Vol. 82; no. 7; pp. 1105 - 1111
Main Authors:	Natkunam, Yasodha, Jong, Daphne, Farinha, Pedro, Gaulard, Philippe, Klapper, Wolfram, Rosenwald, Andreas, Sander, Birgitta, Tooze, Reuben, Advani, Ranjana, Burton, Catherine, Gribben, John G, Kersten, Marie‐José, Kimby, Eva, Lenz, Georg, Molina, Thierry, Morschhauser, Franck, Scott, David, Sehn, Laurie, Stevens, Wendy, Clear, Andrew, Baia, Maryse, Habi, Abdelmalek, Elsensohn, Mad‐Helenie, Langlois‐Jacques, Carole, Maucort‐Boulch, Delphine, Calaminici, Maria
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01.06.2023
Subjects:	B-cell lymphoma Biomarkers Cell size diffuse large B cell lymphoma digital whole slide image Discordance FISH Fluorescence in situ hybridization Gene Rearrangement Growth patterns high‐grade B cell lymphoma Humans Lymphoma Lymphoma, Large B-Cell, Diffuse - diagnosis Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - pathology Myc protein MYC‐rearrangement Nucleoli Pleomorphism Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-6 - genetics Proto-Oncogene Proteins c-myc - genetics Reproducibility Reproducibility of Results digital whole slide image high-grade B cell lymphoma FISH MYC-rearrangement diffuse large B cell lymphoma
ISSN:	0309-0167, 1365-2559, 1365-2559
Online Access:	Get full text
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