Gold nanocages as contrast agents for spectroscopic optical coherence tomography
We describe gold nanocages as a new class of potential contrast agent for spectroscopic optical coherence tomography (OCT). Monodispersed gold nanocages of an approximately 35 nm edge length exhibit strong optical resonance, with the peak wavelength tunable in the near-infrared range. We characteriz...
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| Vydáno v: | Optics letters Ročník 30; číslo 22; s. 3048 |
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| Hlavní autoři: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
15.11.2005
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| ISSN: | 0146-9592 |
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| Abstract | We describe gold nanocages as a new class of potential contrast agent for spectroscopic optical coherence tomography (OCT). Monodispersed gold nanocages of an approximately 35 nm edge length exhibit strong optical resonance, with the peak wavelength tunable in the near-infrared range. We characterized the optical properties of the nanocage by using OCT experiments along with numerical calculations, revealing an absorption cross section approximately 5 orders of magnitude larger than conventional dyes. Experiments with tissue phantoms demonstrated that the nanocages provide enhanced contrast for spectroscopic as well as conventional intensity-based OCT imaging. |
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| AbstractList | We describe gold nanocages as a new class of potential contrast agent for spectroscopic optical coherence tomography (OCT). Monodispersed gold nanocages of an approximately 35 nm edge length exhibit strong optical resonance, with the peak wavelength tunable in the near-infrared range. We characterized the optical properties of the nanocage by using OCT experiments along with numerical calculations, revealing an absorption cross section approximately 5 orders of magnitude larger than conventional dyes. Experiments with tissue phantoms demonstrated that the nanocages provide enhanced contrast for spectroscopic as well as conventional intensity-based OCT imaging.We describe gold nanocages as a new class of potential contrast agent for spectroscopic optical coherence tomography (OCT). Monodispersed gold nanocages of an approximately 35 nm edge length exhibit strong optical resonance, with the peak wavelength tunable in the near-infrared range. We characterized the optical properties of the nanocage by using OCT experiments along with numerical calculations, revealing an absorption cross section approximately 5 orders of magnitude larger than conventional dyes. Experiments with tissue phantoms demonstrated that the nanocages provide enhanced contrast for spectroscopic as well as conventional intensity-based OCT imaging. We describe gold nanocages as a new class of potential contrast agent for spectroscopic optical coherence tomography (OCT). Monodispersed gold nanocages of an approximately 35 nm edge length exhibit strong optical resonance, with the peak wavelength tunable in the near-infrared range. We characterized the optical properties of the nanocage by using OCT experiments along with numerical calculations, revealing an absorption cross section approximately 5 orders of magnitude larger than conventional dyes. Experiments with tissue phantoms demonstrated that the nanocages provide enhanced contrast for spectroscopic as well as conventional intensity-based OCT imaging. |
| Author | Li, Xingde Wiley, Benjamin J Li, Zhi-Yuan Cang, Hu Xia, Younan Sun, Tao Chen, Jingyi |
| Author_xml | – sequence: 1 givenname: Hu surname: Cang fullname: Cang, Hu organization: Department of Bioengineering, University of Washington, Seattle 98195, USA – sequence: 2 givenname: Tao surname: Sun fullname: Sun, Tao – sequence: 3 givenname: Zhi-Yuan surname: Li fullname: Li, Zhi-Yuan – sequence: 4 givenname: Jingyi surname: Chen fullname: Chen, Jingyi – sequence: 5 givenname: Benjamin J surname: Wiley fullname: Wiley, Benjamin J – sequence: 6 givenname: Younan surname: Xia fullname: Xia, Younan – sequence: 7 givenname: Xingde surname: Li fullname: Li, Xingde |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16315717$$D View this record in MEDLINE/PubMed |
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| Snippet | We describe gold nanocages as a new class of potential contrast agent for spectroscopic optical coherence tomography (OCT). Monodispersed gold nanocages of an... |
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| SubjectTerms | Contrast Media Image Enhancement - methods Nanostructures - chemistry Nanostructures - ultrastructure Particle Size Reproducibility of Results Sensitivity and Specificity Tomography, Optical Coherence - methods |
| Title | Gold nanocages as contrast agents for spectroscopic optical coherence tomography |
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